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    MULTIFUNCTIONAL REFERENCE SYSTEM FOR USE IN ANALYTE DETECTION BY FLUORESCENCE
    92.
    发明专利
    MULTIFUNCTIONAL REFERENCE SYSTEM FOR USE IN ANALYTE DETECTION BY FLUORESCENCE 未知

    公开(公告)号：CA2585041A1

    公开(公告)日：2006-05-04

    申请号：CA2585041

    申请日：2005-10-25

    Applicant: HOFFMANN LA ROCHE

    Inventor： HORN CARINA

    IPC: G01N21/64 ,  G01N21/86 ,  G01N33/542

    Abstract: The present invention concerns a system and method for the luminescence detection of an analyte in a liquid sample. The system comprises a support on which an analyte-specific substance and a reference substance are located. The analyte-specific substance is able to emit a first luminescence signal on contact with the analyte and the reference substance is able to emit a second luminescence signal which is substantially quenched by contact with the liquid sample.

    METHOD FOR DETERMINING AN ANALYTE BY MEANS OF AN EXTRACTION LAYER
    95.
    发明专利
    METHOD FOR DETERMINING AN ANALYTE BY MEANS OF AN EXTRACTION LAYER 未知

    公开(公告)号：CA2486043A1

    公开(公告)日：2005-04-30

    申请号：CA2486043

    申请日：2004-10-26

    Applicant: HOFFMANN LA ROCHE

    Inventor： NORTMEYER CHRISTINE ,  HORN CARINA ,  HOENES JOACHIM

    IPC: G01N33/48 ,  G01N33/483 ,  G01N33/52 ,  G01N33/72 ,  G01N33/86 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543

    Abstract: The invention concerns a method for determining an analyte in a liquid sampl e by means of a test system consisting of at least two compartments wherein the detection reactions necessary to determine the analyte in the liquid sample are carrie d out in a first compartment and an analytical determination of at least one substance which participates in the detection reactions and is different from the analyte, t he indicator substance, takes place in a second compartment characterized in that the two compartments are separated in a manner which allows the indicator substance to pass into the second compartment and at least partially prevents passage of other substances that could interfere with the analytical determination of the indicator substance in the second compartment and that at least one other substance which, as a capture substance, can selectively enrich the indicator substance in the second compartment, is present in an immobilized form in the second compartment. Other subject matters of the invention are test systems for carrying out such methods and the use of these test systems for the determination of analytes according to the invention.

    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    99.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152C

    公开(公告)日：2018-07-24

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

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