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公开(公告)号：DE69937895T2
公开(公告)日：2009-01-02
申请号：DE69937895
申请日：1999-10-28
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ALTENBACH ROBERT J , DRIZIN IRENE , KORT MICHAEL E
IPC: C07D335/02 , C07D471/04 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/47 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：PT1278747E
公开(公告)日：2007-01-31
申请号：PT01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ROBERT J ALTENBACH , KORT MICHAEL J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
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公开(公告)号：BRPI0413305A
公开(公告)日：2006-10-10
申请号：BRPI0413305
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PENNER RICHARD J , SCHMIDT ROBERT G JR , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU , LEE CHIH-HUNG
IPC: C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D405/12 , C07D521/00 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , R 6 , R 7 , R 8a , R 8b , R 9 , Z 1 , Z 2 and L are as defined in the description.
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公开(公告)号：AT337319T
公开(公告)日：2006-09-15
申请号：AT01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ALTENBACH ROBERT J , DRIZIN IRENE , KORT MICHAEL J
IPC: C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00 , A61K31/4745
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：DE60103615T2
公开(公告)日：2005-06-09
申请号：DE60103615
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , ALTENBACH J , CARROLL A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
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Patent Agency Ranking
公开(公告)号：DE69823227T2
公开(公告)日：2005-03-10
申请号：DE69823227
申请日：1998-12-16
Applicant: ABBOTT LAB
Inventor： CARROLL A , HOLLADAY W , SULLIVAN P , DRIZIN IRENE , ZHANG Q
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/44 , A61K31/38
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：PT1259510E
公开(公告)日：2004-10-29
申请号：PT01918338
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , DRIZIN IRENE , CARROLL WILLIAM A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
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公开(公告)号：NO317099B1
公开(公告)日：2004-08-09
申请号：NO20003104
申请日：2000-06-16
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , DRIZIN IRENE , HOLLADAY MARK W , SULLIVAN JAMES P , ZHANG HENRY Q
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/44
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：DK1040097T3
公开(公告)日：2004-08-02
申请号：DK98963249
申请日：1998-12-16
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , SULLIVAN JAMES P , DRIZIN IRENE , ZHANG HENRY Q , HOLLADAY MARK W
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/38 , A61K31/44
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：DE69823227D1
公开(公告)日：2004-05-19
申请号：DE69823227
申请日：1998-12-16
Applicant: ABBOTT LAB
Inventor： CARROLL A , HOLLADAY W , SULLIVAN P , DRIZIN IRENE , ZHANG Q
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/44 , A61K31/38
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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