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公开(公告)号：HRP20200664T1
公开(公告)日：2020-07-24
申请号：HRP20200664
申请日：2020-04-24
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ-SHOKRI ALI , ZHANG BEILI , KRAWIEC MARIUSZ
IPC: C07D405/12 , A61K31/4709 , A61P11/00
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公开(公告)号：TN2019000079A1
公开(公告)日：2020-07-15
申请号：TN2019000079
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , BAEK MINSON , BUSCH BRETT BRADLEY , CLEVELAND THOMAS , FRIEMAN BRYAN A , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SIESEL DAVID ANDREW , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK , ZHANG BEILI , ZHOU JINGLAN
IPC: A61P11/12 , C07D498/14
Abstract: Compounds of Formula (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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113.发明专利
公开(公告)号：DK3170818T3
公开(公告)日：2020-04-14
申请号：DK16198922
申请日：2008-12-04
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ-SHOKRI ALI , ZHANG BEILI , KRAWIEC MARIUSZ
IPC: C07D405/12 , A61K31/4709 , A61P11/00
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公开(公告)号：SG10201913606VA
公开(公告)日：2020-02-27
申请号：SG10201913606V
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL , BAEK MINSON , CLEMENS JEREMY , CLEVELAND THOMAS , FERRIS LORI , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HADIDA RUAH SARA , HSIA CLARA , HUGHES ROBERT , JOSHI PRAMOD , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL , MCCARTNEY JASON , MILLER MARK , PARASELLI PRASUNA , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , SIESEL DAVID , STAVROPOULOS KATHY , TERMIN ANDREAS , UY JOHNNY , VAN GOOR FREDRICK , YOUNG TOMOTHY , ZHOU JINGLAN
Abstract: Compounds of Formula (I):pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：AU2019271928A1
公开(公告)日：2019-12-19
申请号：AU2019271928
申请日：2019-11-26
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: The invention relates to prodrug compounds of formula I: O -NO-X Ry wherein R2 , R 3, R, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.
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Patent Agency Ranking
公开(公告)号：CY1121030T1
公开(公告)日：2019-12-11
申请号：CY181101096
申请日：2018-10-24
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: Ηεφεύρεσησχετίζεταιμεενώσεις-προφάρμακατουτύπου I: όπουοι R2, R3, R5, R7 καιΧ είναιόπωςορίζονταιστοπαρόν. Ηεφεύρεσηεπίσηςπαρέχειαποδεκτέςαπόφαρμακευτικήάποψησυνθέσειςπουπεριλαμβάνουντιςενώσειςτηςεφεύρεσηςκαιμεθόδουςχρήσηςτωνσυνθέσεωνστηναγωγήδιαφόρωνδιαταραχών, συμπεριλαμβανομένουτουπόνου. Οιενώσειςτουτύπου I χαρακτηρίζονταιαπόεπωφελείςιδιότητεςδιαλυτότηταςκαιφυσικοχημικέςιδιότητες.
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公开(公告)号：AU2014362255B2
公开(公告)日：2019-08-29
申请号：AU2014362255
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: The invention relates to prodrug compounds of formula I: wherein R
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公开(公告)号：AU2017371200A1
公开(公告)日：2019-07-11
申请号：AU2017371200
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：AU2017336156A1
公开(公告)日：2019-05-02
申请号：AU2017336156
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compounds of Formula (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：LT3080134T
公开(公告)日：2018-11-12
申请号：LT14824658
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
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