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    미토콘드리아 기능 조절제로서의 아릴옥심 유도체
    132.
    发明授权
    미토콘드리아 기능 조절제로서의 아릴옥심 유도체 有权
    ARYLOXIME衍生物作为麻醉功能调节剂

    公开(公告)号：KR101267937B1

    公开(公告)日：2013-05-31

    申请号：KR1020120018465

    申请日：2012-02-23

    Applicant: 한국과학기술연구원

    Inventor： 민선준 ,  배애님 ,  조용서 ,  이재균 ,  김영습 ,  최연희 ,  이지연

    IPC: C07C251/48 ,  A61K31/26 ,  A61P25/00

    Abstract: PURPOSE: Aryloxime derivatives are provided to show excellent activity as a neuroprotective agent acting on mitochondria, therefore, to be useful as a treatment and prevention agent of diseases such as Alzheimer disease, Parkinson's disease, Huntington disease, ischemic disease, diabetes, and schizophrenia. CONSTITUTION: A chemical is selected from aryloxime derivatives represented by Chemical formula 1, and pharmaceutically acceptable salt thereof. In the chemical formula 1; R^1 represents a 4-8 membered azacyclic group or a 7-9 membered azabicylic group, and the azacyclic or azabicyclic group is able to be substituted with 1-3 substituents selected from C1-6 alkyl and benzyl, or be non-substituted; R^2 and R^3 respectively represent a hydrogen group, a halogen group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, or a C1-C6 alkoxy group; and n is an integer of 0, 1, 2 or 3.

    Abstract translation: 目的：提供芳肟衍生物作为作用于线粒体的神经保护剂具有优异的活性，因此可用作诸如阿尔茨海默病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症等疾病的治疗和预防剂。 构成：选自化学式1表示的芳肟衍生物及其药学上可接受的盐。 在化学式1中; R 1表示4-8元氮杂环基或7-9元氮杂双环基，氮杂环或氮杂双环基团可以被1-3个选自C 1-6烷基和苄基的取代基取代，或被取代 ; R 2和R 3分别表示氢基，卤素基，C 1 -C 6烷基，C 1 -C 6卤代烷基或C 1 -C 6烷氧基; n为0,1,2或3的整数。

    디페닐 유도체를 포함하는 항균제
    137.
    发明公开
    디페닐 유도체를 포함하는 항균제 失效
    含有二苯甲基衍生物的抗菌剂

    公开(公告)号：KR1020120079616A

    公开(公告)日：2012-07-13

    申请号：KR1020110000897

    申请日：2011-01-05

    Applicant: 한국과학기술연구원

    Inventor： 배애님 ,  김은경 ,  금교창 ,  서선희 ,  홍승곤 ,  무하마드무다사

    IPC: A61K31/435 ,  A61K31/4418 ,  A61P31/04 ,  A61P31/00

    CPC classification number: A61K31/167 ,  A61K31/12 ,  A61K31/137 ,  A61K31/235 ,  A61K31/24 ,  A61K31/4035 ,  A61K31/4409 ,  Y10S514/924

    Abstract: PURPOSE: An antibacterial agent containing novel diphenyl derivative or pharmaceutically acceptable salt thereof is provided to suppress bacterial fatty acid biosynthesis. CONSTITUTION: An antibacerial agent against mycobacteria contains a compound of chemical formula I or pharmaceutically acceptable salt thereof as an active ingredient. The mycobacteria are Mycobacterium tuberculosis. A composition for preventing or treating mycobacterium infections contains the compound or salt as an active ingredient. The mycobacterium infections are tuberculosis. The composition is manufactured in the form of a pharmaceutical composition administered to mammals and birds.

    Abstract translation: 目的：提供含有新二苯衍生物或其药学上可接受的盐的抗菌剂以抑制细菌脂肪酸生物合成。 构成：抗分枝杆菌的抗菌剂含有化学式I的化合物或其药学上可接受的盐作为活性成分。 分枝杆菌是结核分枝杆菌。 用于预防或治疗分枝杆菌感染的组合物含有化合物或盐作为活性成分。 分枝杆菌感染是结核病。 该组合物以施用于哺乳动物和鸟类的药物组合物的形式制造。

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