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公开(公告)号：CA2219819A1
公开(公告)日：1996-12-19
申请号：CA2219819
申请日：1996-06-03
Applicant: BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , ROMERDAHL CYNTHIA A
Abstract: Novel dolasstatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)tK, in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：DE59206961D1
公开(公告)日：1996-09-26
申请号：DE59206961
申请日：1992-06-17
Applicant: BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , KLUGE MICHAEL , KRONER MATTHIAS , HAAS GERHARD , SCHMIDT ULRICH , GRIESSER HELMUT , RIEDL BERND
Abstract: PCT No. PCT/EP92/01304 Sec. 371 Date Dec. 16, 1993 Sec. 102(e) Date Dec. 16, 1993 PCT Filed Jun. 17, 1992 PCT Pub. No. WO93/00362 PCT Pub. Date Jan. 7, 1993.Antitumor peptides of the formula I where R1, R2, R3, R4 and R5 have the meanings stated in the description, and the preparation thereof.
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公开(公告)号：CA2189691A1
公开(公告)日：1995-11-16
申请号：CA2189691
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of formula (I) are disclosed, wherein R1, R2, R3, and R4 have the meanings indicated in the description, as well as a process for the production of these compounds. The compounds are suitable for use as starting material for the synthesis of substances which have anti-tumour properties.
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公开(公告)号：HU9501754D0
公开(公告)日：1995-08-28
申请号：HU9501754
申请日：1993-12-04
Applicant: BASF AG
Inventor： JANSSEN BERND , HAUPT ANDREAS , ROMERDAHL CYNTHIA , RITTER KURT , KLINGE DAGMAR , KEILHAUER GERHARD , BARLOZZARI TERESA , QIAN XIAO-DONG
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公开(公告)号：NO952366D0
公开(公告)日：1995-06-15
申请号：NO952366
申请日：1995-06-15
Applicant: BASF AG
Inventor： HAUPT ANDREAS , JANSSEN BERND , RITTER KURT , KLINGE DAGMAR , KEILHAUER GERHARD , ROMERDAHL CYNTHIA , BARLOZZARI TERESA , QIAN XIAO-DONG
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Patent Agency Ranking
公开(公告)号：FI945416A0
公开(公告)日：1994-11-17
申请号：FI945416
申请日：1994-11-17
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA
IPC: A61K38/00 , A61K38/08 , A61P35/00 , A61P35/02 , C07K5/062 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/06 , C07K
Abstract: Novel derivates of dolastatin of formula (I) in which R , R , A, B, D, E, F, G, K, X, t, u, v, and w have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：FI945416A
公开(公告)日：1994-11-17
申请号：FI945416
申请日：1994-11-17
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA
IPC: A61K38/00 , A61K38/08 , A61P35/00 , A61P35/02 , C07K5/062 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/06 , C07K
Abstract: Novel derivates of dolastatin of formula (I) in which R , R , A, B, D, E, F, G, K, X, t, u, v, and w have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：CA2189690C
公开(公告)日：2007-06-19
申请号：CA2189690
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR1, wherein Z and R1 have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties. >
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公开(公告)号：BG105978A
公开(公告)日：2002-07-31
申请号：BG10597801
申请日：2001-10-04
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZEICHEL JOHANN-CHRISTIA , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanadine or amidine radical as the terminal group, especially inhibitors of the complement proteases C1s and C1r. 8 claims
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公开(公告)号：TR200103545T2
公开(公告)日：2002-06-21
申请号：TR200103545
申请日：1998-07-07
Applicant: BASF AG
Inventor： JANSSEN BERND , BARLOZZARI TERESA , HAUPT ANDREAS , ZIERKE THOMAS , KLING ANDREAS
Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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