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    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물
    181.
    发明公开
    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물 有权
    吡唑基哌嗪化合物作为钙通道拮抗剂

    公开(公告)号：KR1020120125098A

    公开(公告)日：2012-11-14

    申请号：KR1020110043180

    申请日：2011-05-06

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  서선희 ,  송치만 ,  신선미 ,  아미드,압둘와히드

    IPC: C07D403/12 ,  A61K31/496 ,  A61P25/00

    Abstract: PURPOSE: A pyrazolyl piperazine compound with a pharmaceutical activity to a calcium channel and a pharmaceutical composition containing the same are provided to be used as a pharmaceutical composition for preventing or treating diseases of brain diseases, heart diseases, cancer, and pain. CONSTITUTION: A pyrazolyl piperazine compound is denoted by chemical formula 1. The compound of chemical formula 1 is prepared by binding piperazine compounds of chemical formula 2 and chloride compounds of chemical formula 3 under the presence of a base at 20-30 Deg. C. The base includes an organic base such as an amine-based base and an inorganic base. The reaction solvent is dichloromethane, tetrahydrofurane(THF), dimethyl formamide(DMF), dimethyl aceteamide(DMAC), and dioxane. A pharmaceutical composition for preventing brain diseases, cancer, heart diseases, or pain contains the compound of chemical formula 1.

    Abstract translation: 目的：提供对钙通道具有药学活性的吡唑基哌嗪化合物和含有该通道的药物组合物作为预防或治疗脑疾病，心脏病，癌症和疼痛疾病的药物组合物。 构成：化学式1表示吡唑基哌嗪化合物。化学式1的化合物是通过在20-30度的碱存在下将化学式2的哌嗪化合物和化学式3的氯化合物结合而制备的。 C.碱包括有机碱如胺基和无机碱。 反应溶剂为二氯甲烷，四氢呋喃（THF），二甲基甲酰胺（DMF），二甲基乙酰胺（DMAC）和二恶烷。 用于预防脑疾病，癌症，心脏病或疼痛的药物组合物含有化学式1的化合物。

    입체선택성 3,4―다이메틸렌옥세페인 화합물과 이의 제조방법
    182.
    发明公开
    입체선택성 3,4―다이메틸렌옥세페인 화합물과 이의 제조방법 有权
    选择性的3,4-二甲氧基苯酚化合物的制备及其制备方法

    公开(公告)号：KR1020120095252A

    公开(公告)日：2012-08-28

    申请号：KR1020110014803

    申请日：2011-02-18

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  배애님 ,  울라프,푼나레디

    IPC: C07D313/04 ,  C07D409/04 ,  C07D407/04

    Abstract: PURPOSE: A stereoselectivity 3,4-die methylene jade force pane compound and a manufacturing method thereof are provided to be useful as intermediate which synthesizes the various multicyclic compounds. CONSTITUTION: A stereoselectivity 3,4-die methylene jade force pane compound is represented by chemical formula 1. A manufacturing method of the 3,4-die methylene jade force pane compound comprises the following step: performing Prins cyclization of solvents selected from diethyl ether and tetrahydrofuran under existence of trimethylsilyl trifluoro methansulfonate(TMSOTf) or tin tetrachloride(TiCl4) using aldehyde compound represented by chemical formula 3 as a starting material. The manufacturing method uses 1-2 equivalent weight range of Lewis acid based the alcoholates represented. The Prins reaction temperature is in a range of -78-30 deg. Celsius.

    Abstract translation: 目的：提供立体选择性3,4- die亚甲基ade力玻璃化合物及其制备方法，可用作合成各种多环化合物的中间体。 构成：立体选择性3,4- die亚甲基ade pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane 1. ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether 和三甲基甲硅烷基三氟甲烷磺酸盐（TMSOTf）或四氯化锡（TiCl 4）存在下的四氢呋喃，使用由化学式3表示的醛化合物作为起始原料。 该制造方法使用1-2当量重量范围的路易斯酸所代表的醇化物。 Prins反应温度在-78-30度的范围内。 摄氏度。

    항암활성을 가지는 2,4-다이아미노퀴나졸린 화합물
    187.
    发明公开
    항암활성을 가지는 2,4-다이아미노퀴나졸린 화합물 有权
    具有抗病毒活性的2,4-二氨基喹唑啉化合物

    公开(公告)号：KR1020120038034A

    公开(公告)日：2012-04-23

    申请号：KR1020100097911

    申请日：2010-10-07

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 배애님 ,  남길수 ,  또라트,다나지아튜트라오 ,  추현아 ,  조용서

    IPC: C07D405/12 ,  A61K31/517 ,  A61P35/00

    Abstract: PURPOSE: A 2,4-diaminoquinazoline compound with anticancer activity is provided to be used as an anticancer agent. CONSTITUTION: A 2,4-diaminoquinazoline compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains 2,4-diaminoquinazoline compound of chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of binding 2-chloro-N-(furnylmethyl)quinazoliine-4-amine compounds of chemical formula 2 with an amine compound of chemical formula 3.

    Abstract translation: 目的：提供具有抗癌活性的2,4-二氨基喹唑啉化合物作为抗癌剂。 构成：2,4-二氨基喹唑啉化合物由化学式1表示。抗癌用药物组合物含有化学式1的2,4-二氨基喹唑啉化合物。化学式1化合物的制备方法包括：将2 - 氯-N-（苄基甲基）喹唑啉-4-胺化合物与化学式3的胺化合物。

    ＩＫＫ-β 억제제로서 신규 티아졸리디논 화합물 및 그의 제조방법
    188.
    发明公开
    ＩＫＫ-β 억제제로서 신규 티아졸리디논 화합물 및 그의 제조방법 无效
    新型噻唑烷酮化合物作为IKK-＆beta; 抑制剂及其制备方法

    公开(公告)号：KR1020120035684A

    公开(公告)日：2012-04-16

    申请号：KR1020100097362

    申请日：2010-10-06

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  신계정 ,  배애님 ,  노은주 ,  추현아 ,  최경일 ,  정혜진 ,  김희숙

    IPC: C07D277/24 ,  C07D417/06 ,  A61K31/427 ,  A61P19/02

    Abstract: PURPOSE: A thiazolidinone compound with IKK-beta suppression and a pharmaceutical composition containing the same are provided to prevent and treat rheumatoid arthritis, degenerative arthritis, asthma, and cancer. CONSTITUTION: A thiazolidine-4-one derivative is denoted by chemical formula 1. A pharmaceutical composition for treating inflammatory diseases or cancer contains the compound of chemical formula 1 as an active ingredient. The inflammatory diseases include rheumatoid arthritis, degenerative arthritis, asthma, or chronic obstructive lung diseases. A method for preparing the thiazolidione compound comprises: a step of cyclizing aryl thiourea compound of chemical formula 2 with ethyl 2-chloroacetate or prepare 2-arylimino-thiazolidine-4-one compound of chemical formula 3 or 4; a step of condensing the compound of chemical formula 3 or 4 with aryl aldehyde compound of chemical formula 5.

    Abstract translation: 目的：提供具有IKK-β抑制的噻唑烷酮化合物和含有它们的药物组合物以预防和治疗类风湿性关节炎，退行性关节炎，哮喘和癌症。 构成：噻唑烷-4-酮衍生物由化学式1表示。用于治疗炎性疾病或癌症的药物组合物含有化学式1的化合物作为活性成分。 炎性疾病包括类风湿性关节炎，退行性关节炎，哮喘或慢性阻塞性肺疾病。 制备噻唑烷二酮化合物的方法包括：用2-氯乙酸乙酯环化化学式2的芳基硫脲化合物或制备化学式3或4的2-芳基亚氨基 - 噻唑烷-4-酮化合物的步骤; 将化学式3或4的化合物与化学式5的芳基醛化合物缩合的步骤。

    옥사스파이로 화합 및 이 화합물의 제조방법
    189.
    发明授权
    옥사스파이로 화합 및 이 화합물의 제조방법 有权
    Oxaspiro化合物及其制备方法

    公开(公告)号：KR101084734B1

    公开(公告)日：2011-11-22

    申请号：KR1020090010234

    申请日：2009-02-09

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  김유승 ,  이재균 ,  민선준 ,  배애님 ,  추현아 ,  사티쉬샤브로

    IPC: C07D307/90 ,  C07D307/93

    Abstract: 본 발명은 옥사스파이로 화합물 및 이 화합물의 제조방법에 관한 것으로서, 더욱 상세하게는 메틸렌사이클로알칸다이올 유도체와 카르보 화합물을 출발물질로 사용하여 루이스산 존재하에서 프린스 고리화 반응 및 알킬 자리 옮김 반응을 동시에 수행하여 제조된 하기 화학식 1로 표시되는 신규 옥사스파이로 화합물과 이 화합물의 제조방법에 관한 것이다.

    상기 화학식 1에서, R
    1
    및 R
    2 는 각각 수소원자; C
    1 -C
    6 의 알킬기; 또는 할로겐, 니트로, C
    1 -C
    6 의 알킬, 및 C
    1 -C
    6 의 알콕시 중에서 선택된 1 내지 3개의 치환체로 치환 또는 비치환된 페닐기를 나타내고, 또한 R
    1
    및 R
    2 는 서로 결합하여 5각형 내지 7각형의 지방족 또는 방향족 고리를 형성할 수 있고, n은 0, 1 또는 2를 나타낸다.
    옥사스파이로 화합물, 프린스 반응, 알킬 자리 옮김 반응

    Ｔ-형 칼슘 채널에 활성을 지닌 신규 다이페닐프로판노일 화합물
    190.
    发明公开
    Ｔ-형 칼슘 채널에 활성을 지닌 신규 다이페닐프로판노일 화합물 有权
    具有T型钙通道活性的新型二苯基丙烯酸酯化合物

    公开(公告)号：KR1020110119045A

    公开(公告)日：2011-11-02

    申请号：KR1020100038514

    申请日：2010-04-26

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  최연희 ,  배애님 ,  추현아 ,  임혜원 ,  최기현 ,  서선희 ,  송치만

    IPC: C07D241/04 ,  A61K31/495 ,  A61P25/08 ,  A61P9/12

    CPC classification number: Y02P20/55

    Abstract: PURPOSE: A diphenylpropanoyl compound having T-type calcium channel activity is provided to ensure antagonism to a T-type calcium channel and to be used as a therapeutic agent and anticancer agent. CONSTITUTION: A diphenylpropanoyl is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating hypertension, angina, chronic pain, neurogenic pain or cancer contains a compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of binding a compound of chemical formula 2 with a compound of chemical formula 3.

    Abstract translation: 目的：提供具有T型钙通道活性的二苯基丙酰基化合物，以确保对T型钙通道的拮抗作用，并用作治疗剂和抗癌剂。 构成：二苯基丙酰基由化学式1表示。用于预防和治疗高血压，心绞痛，慢性疼痛，神经源性疼痛或癌症的药物组合物含有化学式1化合物作为活性成分。 制备化学式1的化合物的方法包括将化学式2的化合物与化学式3的化合物结合的步骤。

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