公开(公告)号：EP0965646A4

公开(公告)日：2003-01-02

申请号：EP97932996

申请日：1997-07-24

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KESHI HIROYUKI ,  EDA SOJI ,  UEHARA HIROTSUGU ,  NISHIDA KEIGO ,  MATSUHISA AKIO

IPC: C12N15/09 ,  C07H21/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/01

CPC classification number: C12Q1/689

Abstract: Probes for specifically detecting and identifying H. pylori which serves as an inflammatory bacterium in digestive diseases. These probes contain a fragment formed by completely digesting a DNA carried by H. pylori with a restriction enzyme HindIII. The information of the base sequences of these probes are useful as a structural indication of primers to be used in the construction of probes specific to H. pylori by PCR or as standard sequences suitable for the comparison with genomic DNAs contained in clinical specimens.

公开(公告)号：EP0974658A4

公开(公告)日：2002-10-09

申请号：EP98909856

申请日：1998-03-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEYAMA HIROSHI ,  ABE KANAKO ,  KESHI HIROYUKI ,  MATSUHISA AKIO

IPC: C12N15/09 ,  C07H21/04 ,  C07K14/315 ,  C12N15/00 ,  C12N15/31 ,  C12Q1/68 ,  C12R1/46

CPC classification number: C12Q1/689 ,  C07K14/315

Abstract: Probes obtained by extracting DNAs carried by Streptococcus pyogenes, completely digesting the extracted DNAs with a restriction enzyme HindIII, cloning the same into an appropriate vector and then screening probes containing the DNA fragments inherently carried by S. pyogenes, followed by the clarification of the base sequences of these probes.

公开(公告)号：EP1142993A4

公开(公告)日：2002-08-07

申请号：EP99972675

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: A61K38/00 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12P21/08 ,  G01N33/573 ,  C12N9/50 ,  A01K67/027 ,  C07K16/40 ,  G01N33/53

CPC classification number: C12N9/6424 ,  A01K2217/075 ,  A61K38/00 ,  G01N33/573

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 thus provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues including brain, prostate gland, placenta, testis, pancreas and spleen.

公开(公告)号：EP0856580A4

公开(公告)日：2001-02-07

申请号：EP96901484

申请日：1996-01-25

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA

IPC: A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C07K14/435 ,  C12N15/67 ,  C12P21/02 ,  C12Q1/70

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: A recombinant conglutinin which contains a collagen region consisting of six amino acids containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID NO:3, wherein Xaa stands for a protein-constituting amino acid), the neck region of natural conglutinin and the sugar chain recognition region of natural conglutinin, has an antiviral activity (virus neutralizing activity), and is expected to be applicable to drugs; and a process for detecting anti-influenza A virus activity of a mannose-binding protein (MBP) or a human mannose-binding protein (hMBP) involving the step of treating influenza A virus-infected cells with the MBP or hMBP and measuring the level of the suppression of the budding of the virus in the virus-infected cells. An MBP and an hMBP having an anti-influenza A virus activity are disclosed.

公开(公告)号：EP3103884A4

公开(公告)日：2017-08-23

申请号：EP15746728

申请日：2015-01-29

Applicant: FUSO PHARMACEUTICAL IND

Inventor： SUGIMOTO NORIHIKO ,  EDA SOUJI ,  ASAKURA MASAHIRO ,  ABE KANAKO ,  UEHARA HIROTSUGU ,  KAMEI KAZUMASA ,  UESAKA YOSHIHIKO ,  OKU YUICHI ,  SHIBAHARA YUSUKE

IPC: C12Q1/68 ,  C12M1/00 ,  C12N15/09

CPC classification number: C12Q1/6832 ,  C12Q2537/162 ,  C12Q2565/133 ,  C12Q2565/137

公开(公告)号：EP2559760A4

公开(公告)日：2013-08-07

申请号：EP11750394

申请日：2011-03-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  OTANI KATSUKI

IPC: C12N15/09 ,  C07K14/47

CPC classification number: C07K14/47 ,  C07K14/4726

公开(公告)号：EP2258843A4

公开(公告)日：2012-03-14

申请号：EP09715053

申请日：2009-02-27

Applicant: UNIV HOKKAIDO NAT UNIV CORP ,  FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO KEIICHI ,  TAHARA HIROSHI ,  SUZUKI YUSUKE

IPC: C12N15/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/67 ,  C12N15/85 ,  C12P21/02

CPC classification number: C12N15/85 ,  C12N9/1205 ,  C12N2830/50 ,  C12N2840/102 ,  C12Y207/01095

公开(公告)号：EP1623711A4

公开(公告)日：2006-06-14

申请号：EP04732726

申请日：2004-05-13

Applicant: TEIKOKU SEIYAKU KK ,  FUSO PHARMACEUTICAL IND

Inventor： MATSUSHITA KUNIHIKO ,  HATTORI KENICHI ,  YAMAJI MASAHIRO

IPC: A61K9/70 ,  A61K31/565 ,  A61K31/57 ,  A61L15/58 ,  A61P3/06 ,  A61P5/30 ,  A61P9/10 ,  A61P15/12 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00

CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/565 ,  A61K31/57 ,  A61L15/585 ,  A61K2300/00 ,  C08L39/06 ,  C08L53/02

Abstract: An external patch capable of stable prolonged release and transdermal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt.% of styrene/isoprene/styrene block copolymer, 20 to 70 wt.% of tackifier resin, 10 to 60 wt.% of softener and 1 to 20 wt.% of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.

Abstract translation: 能够稳定延长释放和透皮吸收压敏粘合剂层中所含活性成分激素（雌激素和/或孕激素）的外用贴剂，该外用贴剂确保对皮肤的低刺激性。 具体地说，包含载体并在其上叠加压敏粘合剂层的外贴剂，其特征在于压敏粘合剂层包含作为必需组分的5至50重量％的苯乙烯/异戊二烯/苯乙烯嵌段共聚物，20 至70重量％的增粘树脂，10至60重量％的软化剂和1至20重量％的聚乙烯吡咯烷酮并且含有作为活性成分的雌激素和/或孕激素。

公开(公告)号：EP1132479A4

公开(公告)日：2005-08-10

申请号：EP99972690

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C07K14/47 ,  C12N5/10 ,  C12N9/64 ,  C12N15/85 ,  C12N15/86 ,  C12P21/02

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/6445 ,  C12N2799/026

Abstract: A protein expression vector characterized by containing a secretory signal nucleic acid sequence and, in the 3'-downstream side thereof, a Tag nucleic acid sequence, a scissile nucleic acid sequence and a cloning site, into which a nucleic sequence encoding a target protein can be inserted, in this order.

公开(公告)号：EP1403369A4

公开(公告)日：2005-06-15

申请号：EP02778910

申请日：2002-05-27

Applicant: FUSO PHARMACEUTICAL IND

Inventor： OHNO TSUNEYA ,  MATSUHISA AKIO ,  KESHI HIROYUKI ,  ABE KANAKO ,  SUGIMOTO NORIHIKO ,  UEYAMA HIROSHI ,  EDA SOJI ,  UEHARA HIROTSUGU ,  IWAMI TAKAHISA ,  YAMAMOTO SEIJI ,  ARAKI HIROMASA

IPC: C12Q1/68 ,  G01N33/50 ,  C12N15/09 ,  C12N5/06 ,  C12N5/10 ,  G01N33/53

CPC classification number: G01N33/5047 ,  C12Q1/6841 ,  C12Q1/689 ,  G01N33/5005

Abstract: Phagocytes having taken a foreign microorganism which are prepared by bringing phagocytes into contact with the microorganism and then isolating the phagocytes; a process for producing the same; and a method and a kit with the use of the same. An experimental model whereby the phagocytosis function of phagocytes can be evaluated in vitro .