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11.发明授权
公开(公告)号：KR100523562B1
公开(公告)日：2005-10-25
申请号：KR1020020065744
申请日：2002-10-28
Applicant: 한국과학기술연구원
CPC classification number: A61K31/352 , A61K36/33
Abstract: 본 발명은 손바닥선인장을 에틸 아세테이트로 추출하여 얻은 신경세포 보호효과를 갖는 추출물 및, 이 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 신경세포 보호용 약학 조성물에 관한 것으로, 본 발명의 약학 조성물은 알쯔하이머병, 뇌졸중, 파킨슨병과 같은 뇌신경질환에 의한 뇌신경세포 손상, 허혈로 인한 세포와 조직 손상 또는 심근경색과 같은 심혈관계 질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020020070052A
公开(公告)日：2002-09-05
申请号：KR1020010029824
申请日：2001-05-29
Applicant: 한국과학기술연구원
IPC: G01N33/18
Abstract: PURPOSE: Provided is a kit for examining water quality by measuring the concentration of nitrogen and phosphorus contained in a water soluble sample. CONSTITUTION: The kit for examining water quality contains reagents for measurement of each concentration of ammonia, nitrous acid, nitric acid and phosphoric acid, each comparative color band and a reaction vessel. Water quality is examined by measuring the concentration of ammonia, nitrous acid, nitric acid and phosphoric acid contained in a sample using reagents; analyzing the result to confirm if the sample is contaminated and to estimate what causes its contamination.
Abstract translation: 目的：提供了通过测量水溶性样品中含有的氮和磷浓度来检测水质的试剂盒。 规定：用于检测水质的试剂盒含有用于测量氨，亚硝酸，硝酸和磷酸各浓度的试剂，每个比较色带和反应容器。 通过使用试剂测量样品中所含的氨，亚硝酸，硝酸和磷酸的浓度来检查水质; 分析结果以确定样品是否被污染并估计是什么导致其污染。
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公开(公告)号：KR100347289B1
公开(公告)日：2002-08-07
申请号：KR1019990020954
申请日：1999-06-07
Applicant: 한국과학기술연구원
IPC: C07H21/02
Abstract: 본발명은암세포의시알릴루이스 X (sLeX)에높은특이성과친화성으로접합하는 RNA서열및 이를이용한 sLeX의탐지방법을제공한다. 시알릴루이스 X (sLeX)는염증과암의전이에관련된세포표면표적자이고, 본발명의선택된 RNA는그 접합강도나분자의특이성면에서우월한결과를가지므로, 이는암세포를특이적으로인식할수 있어암세포의탐지화및 암치료제의개발에획기적인결과를줄 수있는분자가될 수있는잠재력을가지고있다.
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公开(公告)号：KR1020020008944A
公开(公告)日：2002-02-01
申请号：KR1020000041969
申请日：2000-07-21
Applicant: 한국과학기술연구원
IPC: A61K36/855 , A61P31/18 , A61P37/00
Abstract: PURPOSE: An anti-HIV agent containing an alcohol extract of Clerodendron trichotomum and a purified compound separated therefrom an as effective component, in particular an inhibitor for HIV integrase is provided, which has no drug resistance or side effects as defects of a reverse transciptase inhibitor and a protease inhibitor. CONSTITUTION: An alcohol extract of Clerodendron trichotomum having a formula 1 has an anti-HIV activity, in particular an inhibiting activity against HIV integrase. In formula, R1 is H or methyl, R2 is H, caffeoyl, or feruloyl, R3 is H, caffeoyl or feruloyl. For an example, 4.8kg Clerodendron trichotomum is extracted in methanol at room temperature and fractionated into dichloromethane and water. The fraction is subjected to column chromatography with sephadex LH-20 and then silica gel column chromatography to produce 880.8mg compound of the formula 1.
Abstract translation: 目的：提供含有Clerodendron trichotomum的醇提取物和从其分离的纯化化合物作为有效成分，特别是HIV整合酶抑制剂的抗HIV剂，其不具有作为逆转录酶抑制剂缺陷的耐药性或副作用 和蛋白酶抑制剂。 构成：具有式1的Clerodendron trichotomum的醇提取物具有抗HIV活性，特别是抗HIV整合酶的抑制活性。 在式中，R 1是H或甲基，R 2是H，咖啡酰基或阿魏酰基，R 3是H，咖啡酰基或阿魏酰基。 例如，4.8kg Clerodendron trichotomum在室温下在甲醇中萃取并分馏成二氯甲烷和水。 将级分用sephadex LH-20进行柱层析，然后用硅胶柱色谱法进行柱色谱，得到880.8mg式1的化合物。
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公开(公告)号：KR1020010076990A
公开(公告)日：2001-08-17
申请号：KR1020000004480
申请日：2000-01-29
Applicant: 한국과학기술연구원
IPC: C07K16/00
CPC classification number: C07K16/40 , C07K16/286 , C07K2317/56
Abstract: PURPOSE: An antibody for amino-RNA and a producing method thereof are provided, thereby the antibody can be easily produced, and it can be used in treatment of self-immunity disease. CONSTITUTION: The antibody for amino-RNA comprises VH of SEQ ID NO: 1 and VL of SEQ ID NO: 2, in which the amino-RNA specifically binds with a receptor of acetylcholine esterase. The method for producing the antibody for amino-RNA comprises the steps of: producing amino-RNA by substituting nucleotides of RNA during transcription from DNA of MG self-antibody to RNA; collecting a spleen from a mouse; carrying out in vitro immunization technique by incubating the spleen cells in a medium containing the amino-RNA for 3 days; fusing the immunized spleen cells with SP2/o-Ag14 and PEG1500; incubating them to produce hybridoma cells; and selecting hybridoma cells capable of producing antibody binding with amino-RNA.
Abstract translation: 目的：提供了用于氨基-RNA的抗体及其制备方法，由此能够容易地制备抗体，可以用于自身免疫性疾病的治疗。 构成：氨基-RNA抗体包含SEQ ID NO：1的VH和SEQ ID NO：2的VL，其中氨基-RNA与乙酰胆碱酯酶的受体特异性结合。 制备氨基-RNA抗体的方法包括以下步骤：通过在从MG自身的DNA转录到RNA的转录过程中用RNA取代RNA来产生氨基RNA; 从小鼠收集脾脏; 通过将脾细胞在含有氨基-RNA的培养基中培养3天进行体外免疫技术; 将免疫的脾细胞与SP2 / o-Ag14和PEG1500融合; 培养它们以产生杂交瘤细胞; 并选择能够产生与氨基-RNA结合的抗体的杂交瘤细胞。
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Patent Agency Ranking
公开(公告)号：KR1020010001606A
公开(公告)日：2001-01-05
申请号：KR1019990020953
申请日：1999-06-07
Applicant: 한국과학기술연구원
IPC: C07H21/02
Abstract: PURPOSE: Provided are an RNA sequence which has a binding specificity to kanamycin A and a selection method of the RNA sequence having a high specificity to an antibiotic such as kanamycin A. Because the RNA sequence is readily used in reverse drug discovery, it can cut costs and is useful in searching a novel target molecule to the kanamycin A. CONSTITUTION: The RNA is selected from the group consisting of SEQ ID NO : 1 - SEQ ID NO : 8 and has a binding specificity to kanamycin A. The RNA sequence is prepared by a 131 bp DNA sequence comprising 70 nucleotides of random sequence as shown in Fig. 1, wherein T7 RNA polymerase of 5'-primer promotes an in vitro transcription and the site of a restriction enzyme is useful in identifying that the inserts have been incorporated into the sequence. The selection method of the RNA sequence having a high specificity to the antibiotic comprises reacting the antibiotic fixed to solid phase with 100-200 bp of the RNA sequence ligated with 70 random nucleotides at 5' or 3' end thereof using a systematic evolution of ligand by exponential enrichment (SELEX) method.
Abstract translation: 目的：提供对卡那霉素A具有结合特异性的RNA序列和对抗生素如卡那霉素A具有高特异性的RNA序列的选择方法。因为RNA序列容易用于反向药物发现，因此可以切割 成本并且可用于在卡那霉素A中搜索新的靶分子。构成：RNA选自SEQ ID NO：1 - SEQ ID NO：8，并且对卡那霉素A具有结合特异性.RNA序列是 由包含70个核苷酸的随机序列的131bp DNA序列制备，如图1所示。 1，其中5'-引物的T7RNA聚合酶促进体外转录，并且限制酶的位点可用于鉴定插入片段已被并入序列。 对抗生素具有高特异性的RNA序列的选择方法包括将固定在固相上的抗生素与其5'或3'末端与70个随机核苷酸连接的DNA序列的100-200bp反应，使用配体的系统进化 通过指数富集（SELEX）方法。
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公开(公告)号：KR100164458B1
公开(公告)日：1999-01-15
申请号：KR1019950007864
申请日：1995-04-04
Applicant: 한국과학기술연구원
IPC: C07D501/24 , C07D501/56
CPC classification number: C07D501/00
Abstract: 다음 일반식(Ⅰ)의 신규한 3-프로페닐 세팔로스포린 화합물 및 그의 제조방법이 제공된다. 본 발명의 암모니오프로페닐 세팔로스포린 화합물은 특히 세팔로스포린계 항생제에 내성이 강한 균주인 엔테로박터 클로아케 P99에 대해 기존의 광범위 항생제로서 널리 알려진 세프타지딤보다 월등한 항균력을 보일 뿐 아니라 그램 양성균에 대해서도 세프타지딤보다 우수한 항균력을 나타낸다.
식중, P는 상기 정의된 바와 같다.-
公开(公告)号：KR1019980039802A
公开(公告)日：1998-08-17
申请号：KR1019960058918
申请日：1996-11-28
Applicant: 한국과학기술연구원
IPC: A61K36/718 , A61K36/756
Abstract: 황련 또는 황백으로부터 약리 활성 물질을 보다 신속하게 정제해내는 방법이 제공된다. 이 방법에 의하면, 황련 또는 황백의 유기 용매 추출액에 ClO
4
- 카운터 이온을 형성하는 화합물을 첨가함으로써 약리 활성 물질을 침전시키고, 침전물을 분배 계수가 높은 용매로 재추출함으로써 베르베린 및 기타 약리 활성을 나타내는 성분들을 간편하고 신속하게 추출·정제할 수 있다.-
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公开(公告)号：KR1019970001164B1
公开(公告)日：1997-01-29
申请号：KR1019930010442
申请日：1993-06-09
Applicant: 한국과학기술연구원
IPC: C07D501/46
Abstract: Cephalosporin(I), useful as an antibiotic, manufacturied by reacting iodomethylcephem(II) and amine or heterocyclic amine(III) at 20-25 deg.C in presence of solvent to give intermediate compound, which is reacted with compound(IV) continuously. In formula, Q is N or CH, P is N-methyl-bis (2-hydroxyethyl)amine, racemic-3,4-trans-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine,(3R,4R)-3,4-dihydroxy-1-methyl pyrrolidine,meso-3,4-dihydroxy-1-methylpyrro-lidine,(2S,4R)-4-hydroxy-1- methyl-2-pyrrolidine methanol,4-cis-dihydroxy-1-methylpyrrolidine,3,4-trans-dihydroxy-1-methylpiperidine and tropine.
Abstract translation: 头孢菌素（I），可用作抗生素，通过碘代甲基头孢烯（II）和胺或杂环胺（III）在20-25℃在溶剂存在下反应制备，得到中间体化合物，其与化合物（IV）连续反应 。 在式中，Q是N或CH，P是N-甲基 - 双（2-羟乙基）胺，外消旋-3,4-反式 - 二羟基-1-甲基吡咯烷，（3R，4R）-3,4-二羟基-1 - 甲基吡咯烷，（3R，4R）-3,4-二羟基-1-甲基吡咯烷，内消旋-3,4-二羟基-1-甲基吡咯 - 啶，（2S，4R）-4-羟基-1-甲基-2- 吡咯烷甲醇，4-顺式 - 二羟基-1-甲基吡咯烷，3,4-反式 - 二羟基-1-甲基哌啶和托品。
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