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    사슬 말단 기능성 고분자를 이용하여 안정화시킨 나노크기 금속 또는 금속염 및 이들의 제조 방법
    12.
    发明公开
    사슬 말단 기능성 고분자를 이용하여 안정화시킨 나노크기 금속 또는 금속염 및 이들의 제조 방법 有权
    使用链末端官能化聚合物稳定的纳米尺寸金属或金属盐及其制备方法

    公开(公告)号：KR1020040014687A

    公开(公告)日：2004-02-18

    申请号：KR1020020047298

    申请日：2002-08-10

    Applicant: 한국과학기술연구원 ,  율촌화학 주식회사

    Inventor： 김정안 ,  김광웅 ,  황승상 ,  신동윤 ,  김장섭 ,  황순근 ,  김건형

    IPC: B82B3/00 ,  B82Y40/00 ,  C08L57/00 ,  B22F9/24

    CPC classification number: B82Y30/00 ,  C08K3/08 ,  C08K3/22 ,  C08K2003/0806 ,  C08K2003/0831 ,  C08K2201/011

    Abstract: PURPOSE: Provided are nano-sized metals or metal salts thereof stabilized by semi-telechelic or telechelic polymers obtained by living anionic polymerization, which has excellent stability in air and forms a nano-structure by simply mixing with a block copolymer. CONSTITUTION: The nano-sized metal particles or metal salts thereof present in a polymer matrix having a functional group at the end of the polymer chain and a molecular weight of 1000-10000, is stable in air, and is represented by the formula selected from the group consisting of the following formulae 1-5, wherein each of R1 and R2 is H, methyl or t-butyl; each of X1 and X2 is independently a carboxyl, hydroxyl, sulfonate, anhydride or thiol group; n is an integer of 10-5000; each of R3 and R4 is H or methyl; each of X2 and X3 is independently a hydroxyl, carboxyl, sulfonate, thiol, amine, tertiary amine or anhydride group; m is an integer of 20-10000; X4 is a hydroxyl, amine or tertiary amine group; Y2 is a hydroxyl, carboxyl, sulfonate, thiol, amine, tertiary amine or anhydride group; A1 is a styrene monomer; B1 is a methyl methacrylate, vinylpyridine or diene monomer; and each of o and p is an integer of 10-5000.

    Abstract translation: 目的：提供通过活性阴离子聚合获得的半遥爪或遥爪聚合物稳定的纳米尺寸金属或其金属盐，其通过简单地与嵌段共聚物混合在空气中具有优异的稳定性并形成纳米结构。 构成：存在于在聚合物链末端具有官能团且分子量为1000-10000的聚合物基质中的纳米尺寸金属颗粒或其金属盐在空气中稳定，并且由选自 由下式1-5组成的组，其中R 1和R 2各自为H，甲基或叔丁基; X1和X2各自独立地是羧基，羟基，磺酸酯，酸酐或硫醇基; n为10-5000的整数; R 3和R 4各自为H或甲基; X2和X3各自独立地是羟基，羧基，磺酸酯，硫醇，胺，叔胺或酸酐基团; m为20-10000的整数; X4是羟基，胺或叔胺基团; Y2是羟基，羧基，磺酸酯，硫醇，胺，叔胺或酸酐基团; A1是苯乙烯单体; B1是甲基丙烯酸甲酯，乙烯基吡啶或二烯单体; o和p各自为10-5000的整数。

    신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물
    13.
    发明公开
    신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 有权
    新的AZETIDINE衍生物和含有它们的抗坏血酸组合物

    公开(公告)号：KR1020130026292A

    公开(公告)日：2013-03-13

    申请号：KR1020110089820

    申请日：2011-09-05

    Applicant: 한국과학기술연구원

    Inventor： 한호규 ,  남기달 ,  한민수 ,  한영휘 ,  송치만 ,  신동윤

    IPC: C07D205/04 ,  A61K31/397 ,  A61P25/24

    CPC classification number: C07D403/06 ,  C07D205/04

    Abstract: PURPOSE: A novel azetidine derivative and an anti-depression composition containing the same are provided to effectively suppress reuptake of dopamine, serotonin, and norepinephrine with reduced side effects. CONSTITUTION: An anti-depression composition contains a novel azeditine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. In chemical formula 1: R_1 is hydrogen or methyl; R_2 is hydrogen, C1-C5 linear or branched alkyl, -COC_6H_5, or substituted or non-substituted phenyl or benzyl; R_3 is a substituted or non-substituted C6-C12 aromatic compound; and X is halogen.

    Abstract translation: 目的：提供一种新的氮杂环丁烷衍生物和含有它们的抗抑郁组合物，以有效抑制多巴胺，5-羟色胺和去甲肾上腺素的再摄取，副作用降低。 构成：抗抑郁组合物含有化学式1的新颖的氮杂衍生物或其药学上可接受的盐。 在化学式1中：R 1是氢或甲基; R 2是氢，C 1 -C 5直链或支链烷基，-COC 6 H 5或取代或未取代的苯基或苄基; R 3是取代或未取代的C 6 -C 12芳族化合物; X为卤素。

    ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ＤＮＡ 염기서열 분석 방법
    15.
    发明公开
    ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ＤＮＡ 염기서열 분석 방법 失效
    使用新型核苷酸二磷酸酯与荧光素3'-O-阻断组作为可逆终止子的DNA测序方法

    公开(公告)号：KR1020110034838A

    公开(公告)日：2011-04-06

    申请号：KR1020090092296

    申请日：2009-09-29

    Applicant: 한국과학기술연구원

    Inventor： 신동윤 ,  안대로 ,  안희철

    IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/533

    CPC classification number: C12Q1/6869 ,  C07H21/02 ,  C12Q2523/107 ,  C12Q2525/186 ,  C12Q2563/107 ,  G01N33/533

    Abstract: PURPOSE: A DNA sequencing using a nucleoside triphosphate with a fluorescent 3'-O-blocking group is provided to sense fluorescence signal attached to 3'-hydroxyl group. CONSTITUTION: A nucleotide monomer contains a reversible fluorescence group conjugated to 3'-hydroxyl group of nucleoside triphosphate. The fluorescence group has a single fluorophore(FL), or a linker which connects the FL and 3'-hydroxyl group. A method for sequencing comprises: a step of synthesizing a nucleotide monomer; a step of polymerizing a template nucleic acid using the nucleotide monomer, DND or RNA polymerase to elongate a nucleotide to a primer; a step of recognizing elongated nucleotide base by sensing fluorescence signal; and a step of removing the fluorophore group conjugated to the 3'-hydroxyl group to recover 3'-OH.

    Abstract translation: 目的：提供使用三磷酸核苷与荧光3'-O-阻断基团进行DNA测序，以检测与3'-羟基连接的荧光信号。 构成：核苷酸单体含有与三磷酸核苷3'-羟基结合的可逆荧光基团。 荧光基团具有单个荧光团（FL）或连接FL和3'-羟基的连接体。 一种测序方法包括：合成核苷酸单体的步骤; 使用核苷酸单体DND或RNA聚合酶聚合模板核酸以将核苷酸延伸至引物的步骤; 通过感测荧光信号识别细长核苷酸碱基的步骤; 以及除去与3'-羟基结合的荧光团以回收3'-OH的步骤。

    인산기-선택적인 형광 프로브를 이용한 포스파타제 활성 측정 방법
    16.
    发明公开
    인산기-선택적인 형광 프로브를 이용한 포스파타제 활성 측정 방법 失效
    磷酸盐特异性荧光探针，其制备方法以及使用其的磷酸酶活性测定方法

    公开(公告)号：KR1020090075514A

    公开(公告)日：2009-07-08

    申请号：KR1020080001394

    申请日：2008-01-04

    Applicant: 한국과학기술연구원

    Inventor： 안대로 ,  신동윤 ,  안희철

    IPC: C07D203/00 ,  G01N33/533 ,  G01N33/53

    Abstract: A method for manufacturing phosphate-selective fluorescence probe is provided to sensitively measure the variation of low concentration and be useful in phosphatase activation measuring method. A phosphate-selective fluorescence probe by binding compound which is generated after covalent of fluorescence material with phosphate binding material of the chemical formulas 1 to 4 with metal ion through coordinate covalent bond. In the chemical formulas, R1 is amino, hydroxyl, thiol, carboxyl, carbonyl, vinyl or allyl group, R2 and R3 are ethyleneglycolyl ether (-(CH2O)n-)(n is integer less than 3), aliphatic hydrocarbon (-(CH2)m-)(m is integer less 3) or amide(-CONH-) group. The fluorescence material is fluorescein, tetramethylrhodamine, BODIPY, Alexa Fluor, Cy5, Cy3 or texas red. A method for analyzing the activation of phosphatase comprises: a step of mixing a phosphate-selective fluorescence probe with a substrate; a step of measuring the value of reaction solution containing a substrate; a step of adding phosphatase and measuring value after the reaction; and a step of comparing the value of pre-reaction solution and after the reaction.

    Abstract translation: 提供磷酸选择性荧光探针的制造方法，以敏感地测量低浓度的变化，并且可用于磷酸酶活化测定方法。 磷酸盐选择性荧光探针，其通过化学式1至4的共价荧光材料与磷酸盐结合材料之间产生的化合物与金属离子通过配位共价键结合。 在化学式中，R1是氨基，羟基，硫醇，羧基，羰基，乙烯基或烯丙基，R2和R3是乙二醇酰基醚（ - （CH 2 O）n - ）（n是小于3的整数），脂族烃（ - （ CH2）m - ）（m为3以下的整数）或酰胺（-CONH-）基。 荧光物质是荧光素，四甲基罗丹明，BODIPY，Alexa Fluor，Cy5，Cy3或德克萨斯红。 用于分析磷酸酶活化的方法包括：将磷酸盐选择性荧光探针与底物混合的步骤; 测量含有底物的反应溶液的值的步骤; 反应后加入磷酸酶和测定值的步骤; 以及比较反应后溶液的值和反应后的步骤。

    이중 자극 응답성 하이드로젤 및 이의 제조 방법
    17.
    发明公开
    이중 자극 응답성 하이드로젤 및 이의 제조 방법 有权
    双刺激氢键共聚物及其生产方法

    公开(公告)号：KR1020040011915A

    公开(公告)日：2004-02-11

    申请号：KR1020020045224

    申请日：2002-07-31

    Applicant: 한국과학기술연구원 ,  율촌화학 주식회사

    Inventor： 김정안 ,  김광웅 ,  김상섭 ,  김건형 ,  신동윤 ,  황순근 ,  김장섭

    IPC: C08G75/30

    CPC classification number: C08F220/54 ,  C08F220/60 ,  C08F293/005 ,  C08F2438/01

    Abstract: PURPOSE: Provided is a method for producing dual stimuli-responsive hydrogel copolymer, which is possible to control the molecular weight of thermoresponsive and pH-responsive hydrogel copolymer, provide resulting polymers with high polymerization yield comparing to the conventional radical polymerization, control the molecular weight and properties of the dual stimuli-responsive hydrogel copolymer, and easily remove residual catalysts after the polymerization due to selective use of polar or non-polar solvent. CONSTITUTION: The method for dual stimuli-responsive hydrogel copolymer responding to heat and pH, comprises the steps of: (a) providing a sulfonamide styrene monomer or sulfonamide acrylic monomer which has different pKa value; (b) providing a thermoresponsive polyisopropyl acrylamide or polymethylene bisacrylamide; (c) copolymerizing the monomer synthesized in the step (a) with polyisopropyl acrylamide or polymethylene bisacrylamide in a polar or non-polar solvent, wherein the steps (b) and (c) are conducted by controlled/living polymerization using a phosphine type catalyst or an amine type catalyst having amine ligand, and alkyl halide initiator. The random- or block hydrogel copolymer produced by the method is represented by the formula 1, 2,and 3, wherein R1 is selected from a group consisting of phenyl, isoxazole, acetyl, methizole, dimethoxine, diazine, methoxypyridazine, methazine, and pyridine, R2 is hydrogen or methyl, m is an integer of 5 to 500, n is an integer of 3 to 500, and y/x ratio is 2/98 to 8/92.

    Abstract translation: 目的：提供双重刺激响应性水凝胶共聚物的方法，其可以控制热响应和pH响应性水凝胶共聚物的分子量，与常规自由基聚合相比，提供具有高聚合产率的聚合物，控制分子量 和双重刺激响应性水凝胶共聚物的性质，并且由于选择性使用极性或非极性溶剂，在聚合后容易除去残留的催化剂。 构成：响应于热和pH的双重刺激响应性水凝胶共聚物的方法包括以下步骤：（a）提供具有不同pKa值的磺酰胺苯乙烯单体或磺酰胺丙烯酸单体; （b）提供热可聚异丙基丙烯酰胺或聚亚甲基双丙烯酰胺; （c）将步骤（a）中合成的单体与聚异丙基丙烯酰胺或聚亚甲基双丙烯酰胺共聚在极性或非极性溶剂中，其中步骤（b）和（c）通过使用膦类催化剂的控制/活性聚合进行 或具有胺配体的胺型催化剂和烷基卤引发剂。 通过该方法制备的随机或嵌段水凝胶共聚物由式1,2和3表示，其中R1选自苯基，异恶唑，乙酰基，甲基咪唑，二甲氧基，二嗪，甲氧基哒嗪，次甲嗪和吡啶 ，R2为氢或甲基，m为5〜500的整数，n为3〜500的整数，y / x比为2/98〜8/92。

    ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ＤＮＡ 염기서열 분석 방법
    18.
    发明授权
    ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ＤＮＡ 염기서열 분석 방법 失效
    使用新型核苷三磷酸荧光3'- O-封闭基团作为可逆终止子的DNA测序方法

    公开(公告)号：KR101107315B1

    公开(公告)日：2012-01-20

    申请号：KR1020090092296

    申请日：2009-09-29

    Applicant: 한국과학기술연구원

    Inventor： 신동윤 ,  안대로 ,  안희철

    IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/533

    CPC classification number: C12Q1/6869 ,  C12Q2563/107 ,  C12Q2525/186 ,  C12Q2523/107

    Abstract: 본 발명은 3'-하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 DNA 염기서열 분석 방법에 관한 것으로, 보다 상세하게는 3'-하이드록실기 부분에 형광신호를 내면서 화학적으로 제거가 가능한 가역적 장애그룹(reversible blocking group)을 부착한 새로운 뉴클레오티드 단량체인 단일 부분이 변형된 가역적 종결자(mono-modified reversible terminator, MRT)를 이용한 합성에 의한 염기서열 분석 방법(sequencing-by-synthesis)에 관한 것이다. 본 발명의 염기서열 분석 방법은 상기 새로운 뉴클레오티드 단량체가 염기서열 사슬의 연장을 중단시킴과 동시에 3'-하이드록실기 부분에 부착된 형광 신호를 감지함으로써 삽입된 염기의 종류를 분석할 수 있으며, 형광 신호 분석 이후 3'-하이드록실기에 부착된 장애그룹이 효과적으로 제거되어서 3'-OH 작용기로 복구되기 때문에 다음 단량체의 삽입을 가능하게 하여 연이어 염기서열 분석을 가능하게 한다.
    DNA 염기서열 분석(DNA sequencing), 중합효소에 의한 염기서열 분 석(sequencing-by-synthesis), 3'-하이드록실기가 변형된 뉴클레오티드(3'-O-modified nucleotide), 형광(fluorescence), 가역적 종결자(reversible terminator).

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