公开(公告)号：AU2003291329A1

公开(公告)日：2004-06-03

申请号：AU2003291329

申请日：2003-11-05

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  SHARMA PADAM N ,  BENNANI YOUSSEF L ,  CURTIS MICHAEL P ,  ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D

IPC: A61P3/00 ,  A61P25/00 ,  C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/092 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  A61K31/40 ,  C07D261/08 ,  C07D295/088 ,  C07D295/116

公开(公告)号：CA2566898C

公开(公告)日：2013-06-18

申请号：CA2566898

申请日：2005-04-29

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  CURTIS MICHAEL P

IPC: C07D513/04 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  C07D401/00 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04 ,  C07D491/02 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02 ,  C07D498/04

Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：CA2737031A1

公开(公告)日：2010-04-01

申请号：CA2737031

申请日：2009-09-28

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  LI TAO ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  BUNNELLE WILLIAM H ,  SCANIO MARC ,  SHI LEI ,  GOPALAKRISHNAN MURALI ,  DONNELLY-ROBERTS DIANA ,  HU MIN ,  SCHRIMPF MICHAEL R ,  MORTELL KATHLEEN H ,  NERSESIAN DIANA L ,  SIPPY KEVIN B

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00 ,  C07D471/08 ,  C12Q1/02

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：CA2647601A1

公开(公告)日：2008-01-03

申请号：CA2647601

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  LYNCH CHRISTOPHER L ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  FAGHIH RAMIN ,  GFESSER GREGORY A

IPC: C07D207/34 ,  A61K31/402 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：CA2505427A1

公开(公告)日：2004-05-27

申请号：CA2505427

申请日：2003-11-05

Applicant: ABBOTT LAB

Inventor： LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  SHARMA PADAM N ,  BLACK LAWRENCE A ,  BENNANI YOUSSEF L ,  CHANG SOU-JEN ,  CURTIS MICHAEL P ,  ALTENBACH ROBERT J ,  COWART MARLON D ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  KU YI-YIN

IPC: A61P3/00 ,  A61P25/00 ,  C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/092 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  A61K31/40 ,  C07D261/08 ,  C07D295/088 ,  C07D295/116

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for prepari ng compounds within the scope of formula (I).

公开(公告)号：UY27212A1

公开(公告)日：2002-10-31

申请号：UY27212

申请日：2002-03-15

Applicant: ABBOTT LAB

Inventor： BENNANI YOUSSEF L ,  COWART MARLON D ,  GFESSER GREGORY A ,  BLACK LAWRENCE A ,  FAGHIH RAMIN

IPC: C07D307/77

Abstract: Los compuestos de fórmula (I) o una sal aceptable para uso farmacéutico, éster, amida o prodroga del mismo, son útiles para la modulación de los receptores de histamina-3 en mamíferos y son útiles para el tratamiento de afecciones que se alivian por administración de ligandos del receptor de histamina-3

公开(公告)号：UY33966A

公开(公告)日：2012-10-31

申请号：UY33966

申请日：2012-03-22

Applicant: ABBOTT LAB

Inventor： ARTHUR GOMTSYAN ,  DAANEN JEROME F ,  GFESSER GREGORY A ,  KORT MICHAEL R ,  LEE CHIH-HUNG ,  MCDONALD HEATH A ,  PUTTFARCKEN PAMELA S ,  VOIGHT ERIC A ,  PHIL KYM

IPC: A61K31/416 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/551 ,  A61P11/14 ,  A61P13/10 ,  A61P29/00 ,  C07C275/26 ,  C07D215/02 ,  C07D215/227 ,  C07D231/56 ,  C07D265/36 ,  C07D401/02 ,  C07D413/02 ,  C07D417/02

Abstract: Compuestos de fórmula (I) o sales aceptables farmacéuticamente, solvatos, o combinaciones de los mismos,donde X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, y m se definen en la descripción. También se describen composiciones que comprenden dichos compuestos y métodos para tratar estados clínicos y trastornos usando dichos compuestos y composiciones.

公开(公告)号：CA2505427C

公开(公告)日：2012-04-03

申请号：CA2505427

申请日：2003-11-05

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  SHARMA PADAM N ,  BENNANI YOUSSEF L ,  CURTIS MICHAEL P

IPC: C07D471/04 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61P3/00 ,  A61P25/00 ,  C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/092 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：AU2008343115A1

公开(公告)日：2009-07-09

申请号：AU2008343115

申请日：2008-12-18

Applicant: ABBOTT LAB

Inventor： HSIEH GIN C ,  ZHAO CHEN ,  BLACK LAWRENCE A ,  LIU HUAQING ,  COWART MARLON D ,  WAKEFIELD BRIAN D ,  GFESSER GREGORY A ,  ALTENBACH ROBERT J

IPC: C07D413/14 ,  A61K31/423 ,  A61K31/428 ,  A61P3/10 ,  A61P25/00 ,  C07D417/14

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

公开(公告)号：CA2566896C

公开(公告)日：2012-10-30

申请号：CA2566896

申请日：2005-04-29

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  CURTIS MICHAEL P

IPC: C07D417/14 ,  A61K31/4709 ,  A61P25/00 ,  A61P25/28 ,  C07D215/12 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).