公开(公告)号：DK1272500T3

公开(公告)日：2005-09-05

申请号：DK00942860

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： KU YI-YIN ,  COOPER ARTHUR J ,  HAIGHT ANTHONY R ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  STONER ERIC J ,  PETERSON MATTHEW J ,  CINK RUSSELL D ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RILEY DAVID ,  WITTENBERGER STEVEN J

IPC: A61K31/70 ,  A61P31/04 ,  C07H17/08

公开(公告)号：HK1053659A1

公开(公告)日：2003-10-31

申请号：HK03104301

申请日：2003-06-16

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  C07H ,  A61K ,  A61P

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：AU2001298065A1

公开(公告)日：2003-09-02

申请号：AU2001298065

申请日：2001-12-26

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JENG ,  FERNANDO DILINIE P ,  HILL DAVID R ,  WITTENBERGER STEVEN J ,  GUPTA ASHOK

IPC: C07C315/04 ,  C07C317/22 ,  C07D317/18 ,  C07D317/28

公开(公告)号：NO20024678D0

公开(公告)日：2002-09-30

申请号：NO20024678

申请日：2002-09-30

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG ,  KURUKULA-SURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

公开(公告)号：AU5123801A

公开(公告)日：2001-10-15

申请号：AU5123801

申请日：2001-03-30

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG ,  KURUKULASURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C231/02

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

公开(公告)号：HRP20130635T1

公开(公告)日：2013-08-31

申请号：HRP20130635

申请日：2013-07-05

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S II ,  HILL DAVID R ,  HAIGHT ANTHONY R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/13 ,  C07D295/155

公开(公告)号：SI2307393T1

公开(公告)日：2013-08-30

申请号：SI200930640

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S II ,  HILL DAVID R ,  HAIGHT ANTHONY R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/00

公开(公告)号：AU2009260044A1

公开(公告)日：2009-12-23

申请号：AU2009260044

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  MCLAUGLIN MAUREEN ANN ,  WANG LEI ,  SHEKHAR SHASHANK ,  MEI JIANZHANG ,  FRANCZYK THADDEUS S II ,  HAIGHT ANTHONY R ,  YU SU

IPC: C07D295/155

Abstract: Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.

公开(公告)号：DE60019976T2

公开(公告)日：2006-02-16

申请号：DE60019976

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN ,  WITTENBERGER

IPC: A61K31/70 ,  A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：AU779219B2

公开(公告)日：2005-01-13

申请号：AU5742900

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  A61K31/70

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.