公开(公告)号：WO2007076035A2

公开(公告)日：2007-07-05

申请号：PCT/US2006049080

申请日：2006-12-20

Applicant: ABBOTT LAB ,  ROCKWAY TODD W ,  BETEBENNER DAVID A ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  COOPER CURT S ,  ANDERSON DAVID D ,  KEMPF DALE J ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  COOPER CURT S ,  ANDERSON DAVID D ,  KEMPF DALE J ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。

公开(公告)号：BRPI0816994A2

公开(公告)日：2015-03-24

申请号：BRPI0816994

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： ROLF WAGNER ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

公开(公告)号：CA2737601C

公开(公告)日：2014-10-21

申请号：CA2737601

申请日：2010-06-10

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI

IPC: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14 ,  C07D401/14 ,  C07D417/14 ,  C07K5/062 ,  C07K5/065

Abstract: Compounds for Formula I effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. (see formula I)

公开(公告)号：SG10201400957UA

公开(公告)日：2014-09-26

申请号：SG10201400957U

申请日：2010-03-25

Applicant: ABBOTT LAB

Inventor： LIU DACHUN ,  BETEBENNER DAVID A ,  PRATT JOHN K ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  TUFANO MICHAEL D ,  WAGNER ROLF

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：HK1167857A1

公开(公告)日：2012-12-14

申请号：HK12108477

申请日：2012-08-29

Applicant: ABBOTT LAB

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LONGENECKER KENTON L ,  PRATT JOHN K ,  STEWART KENT D ,  WAGNER ROLF ,  MARING CLARENCE J

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：AU2012247053A1

公开(公告)日：2012-11-29

申请号：AU2012247053

申请日：2012-11-08

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI

IPC: C07D403/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：AU2010258769B2

公开(公告)日：2012-08-23

申请号：AU2010258769

申请日：2010-06-10

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI

IPC: C07D403/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：NZ584720A

公开(公告)日：2012-07-27

申请号：NZ58472008

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G

IPC: C07D417/10 ,  A61K31/513 ,  A61P31/12 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10

Abstract: Disclosed are Uracil or Thymine derivatives of formula (I) examples of which are: (E)-N-(4-(3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide; (E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide (Z)-N-(4-(2-(3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-chlorovinyl)phenyl)methanesulfonamide; (E)-1-(3-tert-butyl-5-(4-fluorostyryl)-4-methoxyphenyl) dihydropyrimidine-2,4(1H,3H)-dione; The compounds are for use in treating Hepatitis C

公开(公告)号：AU2012203474A1

公开(公告)日：2012-07-05

申请号：AU2012203474

申请日：2012-06-14

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI

IPC: C07D403/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：DK2203431T3

公开(公告)日：2011-11-21

申请号：DK08832330

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10