公开(公告)号：DK1037886T3

公开(公告)日：2003-08-25

申请号：DK98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：ZA9704806B

公开(公告)日：1997-12-30

申请号：ZA9704806

申请日：1997-05-30

Applicant: ABBOTT LAB

Inventor： DELLARIA JR JOSEPH F ,  GANE TODD H ,  WOODS KEITH W

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

公开(公告)号：CA2672860A1

公开(公告)日：2008-07-10

申请号：CA2672860

申请日：2007-12-12

Applicant: ABBOTT LAB

Inventor： WOODS KEITH W ,  GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods o f treating patients using them are disclosed.

公开(公告)号：ES2198088T3

公开(公告)日：2004-01-16

申请号：ES98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：CA2470214A1

公开(公告)日：2003-06-26

申请号：CA2470214

申请日：2002-12-12

Applicant: ABBOTT LAB

Inventor： HUTCHINS CHARLES ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  STOLL VINCENT S ,  ABRAMS JASON N ,  DINGES JURGEN ,  ZHU GUI-DONG ,  DIEBOLD ROBERT ,  SONG XIAOHONG ,  ROSENBERG SAUL H ,  FISCHER JOHN P ,  LI QUN ,  GANDHI VIRAJ ,  WOODS KEITH W ,  PACKARD GARRICK ,  THOMAS SHEELA A ,  LI TONGMEI

IPC: C07D239/48 ,  A61K31/416 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/502 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61P35/00 ,  A61P43/00 ,  C07D213/63 ,  C07D213/65 ,  C07D213/75 ,  C07D213/82 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D475/02 ,  C07D495/04 ,  C07D498/04

Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhib it protein kinases and methods of inhibiting protein kinases in a patient.

公开(公告)号：AT239012T

公开(公告)日：2003-05-15

申请号：AT98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：BR9813468A

公开(公告)日：2001-11-13

申请号：BR9813468

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVISON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：BG104584A

公开(公告)日：2001-01-31

申请号：BG10458400

申请日：2000-07-06

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having formula or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal. 30 claims

公开(公告)号：NO20003018A

公开(公告)日：2000-08-04

申请号：NO20003018

申请日：2000-06-13

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

CPC classification number: C07D401/04 ,  C07D251/18 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

公开(公告)号：NO20003018D0

公开(公告)日：2000-06-13

申请号：NO20003018

申请日：2000-06-13

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02 ,  C07D

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.