公开(公告)号：DE3936594A1

公开(公告)日：1991-03-28

申请号：DE3936594

申请日：1989-11-03

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED DR ,  FRIEDRICH THOMAS DR ,  MEYER THOMAS DR ,  STRUBE KARL-HERMANN DR

IPC: A61K31/715 ,  A61K38/45 ,  A61K38/46 ,  A61K38/54 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  C12N9/10

Abstract: The description relates to the use of gamma glutamyl transferases in the treatment of diseases.

公开(公告)号：DE19637516C1

公开(公告)日：1998-03-12

申请号：DE19637516

申请日：1996-09-13

Applicant: BASF AG

Inventor： GEHRER EUGEN DR ,  FRIEDRICH THOMAS DR

IPC: C07B61/00

公开(公告)号：DE19631395A1

公开(公告)日：1998-02-05

申请号：DE19631395

申请日：1996-08-02

Applicant: BASF AG

Inventor： FUCHS HARALD PROF DR ,  FRIEDRICH THOMAS DR ,  SCHREPP WOLFGANG DR

IPC: G01N33/543 ,  G01Q60/20 ,  G01N33/533 ,  G01N21/64

Abstract: In an active substance screening process, an active substance is detected by observing changes in a signal (S) by means of a scanning nearfield optical microscope (SNOM). Also disclosed is a device suitable for carrying out this process and comprising the SNOM, a device for receiving single or multiple samples and a control unit.

公开(公告)号：DE19631326A1

公开(公告)日：1998-02-05

申请号：DE19631326

申请日：1996-08-02

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR ,  SCHREPP WOLFGANG DR ,  AKARI SABRI DR

IPC: G01N33/532 ,  G01N23/225 ,  G01N33/543 ,  G01Q60/42 ,  H01J37/28

公开(公告)号：DE19605126A1

公开(公告)日：1997-08-14

申请号：DE19605126

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  RADITSCH MARTIN DR ,  RUEBSAMEN KLAUS DR ,  HOEFFKEN HANS WOLFGANG DR ,  SCHWEDEN JUERGEN DR ,  FRIEDRICH THOMAS DR

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K14/745 ,  A61K38/57 ,  C07H21/04 ,  A61K38/36

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：DE4433458A1

公开(公告)日：1996-03-21

申请号：DE4433458

申请日：1994-09-20

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR ,  BIALOJAN SIEGFRIED DR ,  DESSER SHERWIN S PROF DR

IPC: A61K38/00 ,  C07K14/815 ,  C12Q1/56 ,  C07K14/435 ,  A61K38/53 ,  C12N9/74 ,  C12N9/99

Abstract: Thrombin-inhibiting proteins (I) from leeches of the spp. Desserobdella ornata and D. picta are new.

公开(公告)号：DE4429239A1

公开(公告)日：1996-02-22

申请号：DE4429239

申请日：1994-08-18

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR ,  HORN DIETER DR ,  KLINGLER JUERGEN DR ,  WIESE HARM DR

IPC: G01J3/457 ,  G01N21/64 ,  G01P5/22 ,  G01F1/712 ,  G01N13/00

Abstract: The spectroscopy method involves feeding light from a stimulation light source (1) via a first optical fibre (2) to a fibre coupler (3) and from there via a second optical fibre (4) to a specimen (6). Fluorescent light emitted from particles in the specimen are fed via the second optical fibre back to the coupler and from there via a third optical fibre (8) to a detector (10). Alternatively, the light from the source can be fed to the specimen via a first optical fibre and fluorescent light from particles in the specimen passed via a second fibre to a detector, whereby the ends of the fibres facing the specimen are oriented w.r.t. each other so that emitted stimulation light passes to a specimen region from which fluorescent light will be detected.

公开(公告)号：DE4303646A1

公开(公告)日：1994-08-11

申请号：DE4303646

申请日：1993-02-09

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR

IPC: A61K38/22 ,  A61K38/46 ,  A61K38/57 ,  A61K38/58 ,  A61P25/00 ,  A61K37/02

公开(公告)号：DE3939801A1

公开(公告)日：1991-06-06

申请号：DE3939801

申请日：1989-12-01

Applicant: BASF AG

Inventor： MEYER THOMAS DR ,  FRIEDRICH THOMAS DR ,  KOERWER WOLFGANG DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K35/62 ,  A61K38/00 ,  C12N9/48

Abstract: Described is a protein which dissolves blood clots, prepared fromthe leech Hirudo Medicinalis, containing the sequences 1-13 listed in the sequence protocoland capable of splitting epsilon -( alpha -glutamyl)-lysine compounds, plus its muteins and natural variants with a comparable action.

公开(公告)号：DE3931839A1

公开(公告)日：1991-04-04

申请号：DE3931839

申请日：1989-09-23

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR ,  KOERWER WOLFGANG DR ,  BIALOJAN SIEGFRIED DR ,  KUENAST CHRISTOPH DR

IPC: A61K35/56 ,  A61K38/00 ,  A61K39/00 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/15 ,  C12P21/02

Abstract: A new protein is described which has a molecular weight of about 15,000 daltons and the N-termination SDYEFPPPKKXRPG. The protein is suitable for the control of disease and the protecion of grazing cattle from ticks.