公开(公告)号：AU706859B2

公开(公告)日：1999-06-24

申请号：AU7491296

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：MX9801167A

公开(公告)日：1998-04-30

申请号：MX9801167

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER NIKOLAUS ,  RUCK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS DIETER ,  BAUMGARTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCH JAN

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08J09/16

Abstract: La presente invencion se refiere a un proceso continuo para la preparacion de polímeros de estireno expansible por polimerizacion del estireno en presencia de agentes de soplado en 3 pasos: a. prepolimerizacion del estireno en bloque, b. dispersion del prepolímero en una fase acuosa, y c. polimerizacion del prepolímero hasta terminacion en suspension acuosa.

公开(公告)号：NO981793D0

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JAERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：AU6822496A

公开(公告)日：1997-03-19

申请号：AU6822496

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER NIKOLAUS ,  RUCK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS DIETER ,  BAUMGARTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCH JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08L25/04

Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.

公开(公告)号：DE19530765A1

公开(公告)日：1997-02-27

申请号：DE19530765

申请日：1995-08-22

Applicant: BASF AG

Inventor： LAY PETER ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL DR ,  ZETTLER HANS-DIETER ,  BAUMGAERTEL MICHAEL DR ,  DEMBEK GERHARD DR ,  HAHN KLAUS DR ,  HOLOCH JAN DR ,  HUSEMANN WOLFRAM DR ,  KAEMPFER KNUT DR

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08F212/08

Abstract: A process is disclosed for continuously producing expandable styrene polymers by polymerising styrene in the presence of expanding agents in three steps: (a) prepolymerising styrene in the mass; (b) dispersing the prepolymer in an aqueous phase; and (c) polymerising the prepolymer in an aqueous suspension.

公开(公告)号：DE4202212A1

公开(公告)日：1993-07-29

申请号：DE4202212

申请日：1992-01-28

Applicant: BASF AG

Inventor： SCHIESSL MICHAEL ,  SCHLARB BERNHARD DR ,  HOFFMANN HELMUT ,  SCHWARZENBACH ELMAR DR

IPC: C08J3/07 ,  C08J3/03 ,  C08L33/04

公开(公告)号：DE3934934A1

公开(公告)日：1991-04-25

申请号：DE3934934

申请日：1989-10-20

Applicant: BASF AG

Inventor： PFISTER JUERGEN DR ,  SCHIESSL MICHAEL ,  NACHTRAB RAINER

IPC: B01J27/08 ,  B01J19/20 ,  C07B61/00 ,  C07C46/00 ,  C07C46/02 ,  C07C50/34 ,  C07C50/38

公开(公告)号：ES2138423T3

公开(公告)日：2000-01-01

申请号：ES97113339

申请日：1997-08-01

Applicant: BASF AG

Inventor： WUNSCH JOSEF DR ,  SCHIESSL MICHAEL ,  DIENER RALPH DR

IPC: C08F4/642 ,  B01J19/20 ,  B01J19/24 ,  C08F4/659 ,  C08F4/6592 ,  C08F12/04 ,  C08F112/00 ,  C08F112/08

Abstract: A process for the production of an essentially syndiotactic and partially crystalline polymer (I) containing vinyl aromatic monomers is claimed. (I) is prepared form a reaction mixture containing vinyl aromatic compounds (II), metallocene complexes (III) and one or co-catalysts (IV) consisting of strong, neutral Lewis acid or Bronsted acid cations. The components are mixed prior to addition to the reactor. An apparatus is also claimed comprising a reservoir to contain a mixture of (II) and (IV), a reservoir to contain (III) plus means to dose the contents of the 2 reservoirs to a pre-mixer that is connected to the reactor vessel.

公开(公告)号：ZA9707399B

公开(公告)日：1999-02-18

申请号：ZA9707399

申请日：1997-08-18

Applicant: BASF AG

Inventor： BRUCHMANN BERND ,  REIF MARTIN ,  HOFSCHEUER WERNER ,  JAEHME JOACHIM ,  LANGER WERNER ,  RENZ HANS ,  MOHRHARDT GUENTER ,  SCHIESSL MICHAEL

IPC: C07C273/18 ,  C07C275/62 ,  C08G18/08 ,  C08G18/30 ,  C08G18/32 ,  C08G18/78 ,  C08G ,  C08J ,  C09D

CPC classification number: C08G18/7831 ,  C07C273/1827 ,  C08G2101/0008 ,  C08G2101/0025 ,  C07C275/62

公开(公告)号：PL327395A1

公开(公告)日：1998-12-07

申请号：PL32739596

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.