公开(公告)号：DE3717394A1

公开(公告)日：1988-12-01

申请号：DE3717394

申请日：1987-05-23

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  STEINER GERD DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WEIFENBACH HARALD DR

IPC: A61K31/40 ,  A61P25/20 ,  C07D207/06 ,  C07D207/08

公开(公告)号：DE3242922A1

公开(公告)日：1984-05-24

申请号：DE3242922

申请日：1982-11-20

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/215 ,  A61K31/265 ,  A61P25/24 ,  A61P25/26 ,  C07C47/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07C217/48 ,  C07C219/22 ,  C07C239/00 ,  C07C271/10 ,  C07C313/00 ,  C07C319/20 ,  C07C323/12 ,  C07C323/25 ,  C07D295/08 ,  C07D295/084 ,  C07D295/10 ,  C07D295/104 ,  C07C93/06 ,  C07C93/187 ,  C07C149/42

公开(公告)号：DE3108426A1

公开(公告)日：1982-09-23

申请号：DE3108426

申请日：1981-03-06

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D223/20 ,  C07D403/04 ,  A61K31/55

Abstract: The invention relates to 11-chloromethylenemorphanthridines substituted in the 6-position, which are also called 11-chloromethylenedibenzo[b,e]azepines, processes for their preparation and therapeutic compositions containing them, which can be used as sedatives, hypnotics, tranquillisers or neuroleptics.

公开(公告)号：DE3101502A1

公开(公告)日：1982-08-26

申请号：DE3101502

申请日：1981-01-19

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  C07D403/12 ,  C07D413/12

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DE4425145A1

公开(公告)日：1996-01-18

申请号：DE4425145

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  RENDENBACH-MUELLER BEATRICE DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12 ,  A61K31/495 ,  C07D401/14

Abstract: The use is disclosed of thiazole and thiadiazole compounds having the formula (I), in which R , A, B and Ar have the meanings given in the description. These compounds have a high affinity to the dopamine D3 receptor and are therefore useful for treating diseases of the central nervous system.

公开(公告)号：DE4341402A1

公开(公告)日：1995-06-08

申请号：DE4341402

申请日：1993-12-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D209/02 ,  C07D209/46 ,  C07D209/52 ,  C07D209/90 ,  C07D209/96 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/14 ,  C07B37/10

Abstract: PCT No. PCT/EP94/03910 Sec. 371 Date Apr. 19, 1996 Sec. 102(e) Date Apr. 19, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15312 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：DE3724756A1

公开(公告)日：1989-02-09

申请号：DE3724756

申请日：1987-07-25

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  UNGER LILIANE DR

IPC: A61K31/34 ,  A61K31/343 ,  A61P21/00 ,  A61P25/02 ,  A61P25/18 ,  C07D307/79 ,  C07D307/86 ,  C07D405/12

Abstract: Benzofurancarboxamides with basic substituents, of the formula I … … in which R and X have the meanings given in the description.

公开(公告)号：DE3242923A1

公开(公告)日：1984-05-24

申请号：DE3242923

申请日：1982-11-20

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR

IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D267/08 ,  C07D267/10

公开(公告)号：DE3144138A1

公开(公告)日：1983-05-19

申请号：DE3144138

申请日：1981-11-06

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO DR ,  SCHLECKER RAINER DR ,  FRANKE ALBRECHT DR ,  REICHENEDER FRANZ DR ,  AMANN AUGUST DR MED ,  TESCHENDORF HANS-JUERGEN DR ME ,  KRETZSCHMAR ROLF PROF DR MED ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：DE3101456A1

公开(公告)日：1982-09-02

申请号：DE3101456

申请日：1981-01-19

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  STEINER GERD DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P9/02 ,  A61P11/08 ,  A61P25/08 ,  A61P25/20 ,  C07D231/12 ,  C07D231/38 ,  C07D233/60 ,  C07D233/88 ,  C07D239/42 ,  C07D261/08 ,  C07D295/06 ,  C07D295/092 ,  C07D521/00 ,  C07D403/12 ,  C07D403/10 ,  C07D413/12 ,  C07D413/10

Abstract: Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula I where R1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.