公开(公告)号：JPH11209319A

公开(公告)日：1999-08-03

申请号：JP1434998

申请日：1998-01-27

Applicant: KAO CORP

Inventor： OBA TAKASHI ,  ONO TOSHIYA ,  YAMAGUCHI MASAKAZU ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: A61K8/30 ,  A61K8/34 ,  A61K8/49 ,  A61K31/075 ,  A61K31/085 ,  A61P17/00 ,  C07C43/20 ,  C07C43/23 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific end alkyloxyalkylene chain, providing a reduced undesirable side effect and skin irritation, capable of rapidly imparting an effect of a strong warm feeling to skin when using the compound, capable of sustaining the feeling for a long period and useful as a skin preparation for external use. SOLUTION: This new production is the one of formula I [R to R are each H, OH or a 1-4C (branched) alkoxy, or two of the R to R form an α- methylenedioxy by binding to each other, with the proviso that all of the R to R are not simultaneously H; R is CH2 CH2 O, CH2 CH(CH3 )O or CH(CH3 )CH2 O; R is a 1-6C (branched) alkyl; (n) is 1-3], e.g. 2-methoxyethyl vanillyl ether. The compound of formula I is obtained by reacting a compound of formula II (X is a halogen) with a compound of formula III in a solvent or without the solvent.

公开(公告)号：JPH06128193A

公开(公告)日：1994-05-10

申请号：JP28005192

申请日：1992-10-19

Applicant: KAO CORP

Inventor： ONO TOSHIYA ,  YOSHINO KOJI ,  KAWAMATA AKIRA

IPC: C07C67/303 ,  C07C67/343 ,  C07C67/44 ,  C07C69/24 ,  C07C69/533

Abstract: PURPOSE:To obtain the subject compound useful as a blend ingredient of hair cosmetics and an antimicrobial agent, a pharmaceutical agent, etc., using a readily available raw material by subjecting omega-phosphonium fatty acid ester to Wittig reaction with an aldehyde. CONSTITUTION:A omega-phosphonium fatty acid ester expressed by formula I [R is 1-6C alkyl or alkenyl; R is hydrocarbon; X is halogen; (m) is 5-16] and prepared by reacting a omega-halofatty acid ester with a phosphine compound is dissolved in N,N-dimethylformamide and sodium methoxide is added to the solution and the mixture is stirred at ambient temperature for 20min and a compound expressed by formula II [R and R are methyl or ethyl; (n) is 0 or 1] (e.g. 2-methylbutyl aldehyde) is added to the reactional product and made to react with the reactional product at ambient temperature for 3hr to provide the objective branched fatty acids expressed by formula III (e.g. 13-methyl-11- pentadecenoic acid methyl ester) and useful as a blend ingredient of hair cosmetics, antimicrobial agent, therapeutic acid, etc.

公开(公告)号：JPH1017441A

公开(公告)日：1998-01-20

申请号：JP17653196

申请日：1996-07-05

Applicant: KAO CORP

Inventor： KAJINO TAKAYOSHI ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: A61K8/00 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/04 ,  A61K7/09

Abstract: PROBLEM TO BE SOLVED: To obtain a composition capable of permanently straightening curly or twisted hair by nature without damaging the normal hair, containing a keratin-reducing substance and a guanidine derivative as active ingredients. SOLUTION: This hair treatment agent composition contains, as active ingredients, 1-20wt.% of a keratin-reducing substance (e.g. thioglycolic acid) and 0.1-30wt.% of a guanidine derivative of the formula (-N ring is a heterocyclic group such as of azetidine, pyrrolidine or piperidine; R and R are each H, an alkyl, hydroxyl, etc.; Z and Z are each H, an alkyl or alkenyl) or an acid-added salt thereof, and pref. formulated with 0.5-50wt.% of an organic solvent (e.g. n-propanol). The compound of the formula is e.g. N-(aminoiminomethyl)-trans-4-hydroxy-L-proline. The composition can be prepared by a conventional means into an one-pack or two-pack type curly hair corrective, straight perming agent, permanent wave agent, etc.

公开(公告)号：JPH09202709A

公开(公告)日：1997-08-05

申请号：JP27462796

申请日：1996-10-17

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  OGAWA AYUMI ,  TSUKAHARA KAZUE ,  TAKEMA YOSHINORI ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: C07H15/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/37 ,  A61K8/41 ,  A61K8/43 ,  A61K8/46 ,  A61K8/60 ,  A61K8/68 ,  A61Q19/00 ,  C07C279/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a skin cosmetic capable of exhibiting excellent crease improving effect and good feeling to users by combining a guanidine derivative having a specific structure or its acid addition salt with a synthetic sphingosine. SOLUTION: This skin cosmetic is obtained by combinedly using (A) a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond, CO or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, an alkyl, (AO)m -(BO)n -D-E] of formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phoshoric acid] or its acid addition salt and (B) a synthetic sphingosine derivative of formula III (R is a 4-40C hydrocarbon; R to R are each H or a 1-10C hydrocarbon; X and Y are each H or an alkyl). The skin cosmetic is preferably obtained by blending 0.001-50wt.% component A with 0.0001-10wt.% component B. An organic acid or its ester in an amount of 0.001-30wt.% may further be added to the system. The component of formula I is e.g. obtained from a compound of formula IV.

公开(公告)号：JPH11209320A

公开(公告)日：1999-08-03

申请号：JP1434898

申请日：1998-01-27

Applicant: KAO CORP

Inventor： ONO TOSHIYA ,  OBA TAKASHI ,  YAMAGUCHI MASAKAZU ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: A61K8/30 ,  A61K8/34 ,  A61K31/09 ,  A61P17/00 ,  C07C43/205 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific (substituted) alkyl substituent, providing a reduced undesirable side effect and skin irritation, capable of rapidly imparting an effect of a strong warm feeling to skin when using the compound, capable of sustaining the feeling for a long period and useful as a skin preparation for external use. SOLUTION: This new compound is the ore of the formula [R is a 3-6C (branched) alkyl], e.g. veratryl n-butyl ether. The compound of the formula is obtained by reacting 3,4-dimethoxybenzyl halide with a corresponding alkoxide in a solvent or without the solvent. The compound is preferably used as a skin preparation for external use in a dosage form such as a lotion, an emulsion, a skin lotion, a dentifrice, a soap, a cataplasm and a cream regulated so as to include 0.001-10 wt.%, preferably 0.01-5 wt.% compound of the formula.

公开(公告)号：JPH1143457A

公开(公告)日：1999-02-16

申请号：JP20135597

申请日：1997-07-28

Applicant: KAO CORP

Inventor： HOSHINO TADAHIDE ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: B01F17/42 ,  C07B61/00 ,  C07C41/16 ,  C07C43/17

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate, etc., for producing surfactants or oil- and water-proofing agents in high purity and in high yield by reacting a specific alcohol with an allyl halide in the presence of a solid alkali using a tertiary alcohol as a reaction solvent. SOLUTION: This allyl perfluoroalkyl expressed by Rf -(CH2 )n -O-CH2 -CH=CH2 is obtained by reacting a perfluoroalkyl alcohol of Rf -(CH2 )n -OH [Rf is a perfluoroalkyl; (n) is 1-12], (e.g. 2,2,2-trifluoroethanol, etc.), with an allyl halide (e.g. allyl chloride, etc.), in the presence of a solid alkali (preferably sodium hydroxide having 0.01-1 mm particle size) using preferably 1-300 wt.% of a tertiary alcohol (preferably 2-methyl-2-propanol) as a solvent based on the perfluoroalkyl alcohol at a temperature equal to or less than the boiling point of the allyl halide for 0.5-2 hours.

公开(公告)号：JPH1135424A

公开(公告)日：1999-02-09

申请号：JP19549397

申请日：1997-07-22

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  OISHI SUSUMU ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: A61K8/00 ,  A61K8/34 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61K7/06

Abstract: PROBLEM TO BE SOLVED: To obtain a hair cosmetic good in feeling when applied and capable of imparting the hair after dried with excellent wiriness esp. even in neutral region, by including a specific guanidine derivative. SOLUTION: This hair cosmetic is obtained by formulating 0.001-50 wt.% of a guanidine derivative of formula I [formula II represents a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine, and morpholine; R and R are each H, (hydroxy or carboxy)alkyl, hydroxyl, carboxyl or amidino; Z and Z are each H, a (substituted) alkyl or alkenyl] [e.g. 1- amidinopyrrolidine (1-pyrrolidinecarboxyamidine)] or an acid addition salt thereof, singly or a combination of two or more kinds thereof, and pref. furthermore, a surfactant, aromatic alcohol(s) and/or glycolic acid.

公开(公告)号：JPH09263511A

公开(公告)日：1997-10-07

申请号：JP26626796

申请日：1996-10-07

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  TAKEMA YOSHINORI ,  YAMAZAKI SEIJI ,  KAWADA YUZO ,  YAMAMURO AKIRA ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: C07H5/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/43 ,  A61K8/49 ,  A61K8/60 ,  A61K8/68 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject preparation capable of persisting an excellent flexibility-imparting effect to horny layers and an excellent skin wrinkle- improving effect for a long time and useful for skin-softening cosmetics, antiaging cosmetics, etc. SOLUTION: This preparation for external uses for skins contains a guanidine derivative of formula I (R is a hydrocarbon group, an aromatic ring group, an aralkyl group, etc.; R is H, a hydrocarbon group) or its acid adduct, a synthetic sphingosine derivative of formula II (R is a 4-40C hydrocarbon group; R , R , R , R , R are each H, a 1-10C hydrocarbon; X, Y are each H, a 1-6C alkyl which may have an oxygen atom), and an organic acid such as a dicarboxylic acid or its ester. The guanidine derivative, the synthetic sphingosine derivative, and the organic acid or its ester are preferably compounded in amounts of 0.001-50wt.%, 0.0001-10wt.% and 0.001-30wt.%, respectively, in the preparation.

公开(公告)号：JPH09202710A

公开(公告)日：1997-08-05

申请号：JP27462896

申请日：1996-10-17

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  OGAWA AYUMI ,  TSUKAHARA KAZUE ,  TAKEMA YOSHINORI ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61K8/43 ,  A61K8/46 ,  A61Q19/00 ,  A61Q19/08 ,  C07C279/08 ,  C07C279/14 ,  C07C309/15 ,  C07F9/09 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a wrinkles improver containing a guanidine derivative having a specific structure or its acid addition salt as an active ingredient, capable of suppressing occurrence of wrinkles without impairing normal skin physiology and excellent in effect for eliminating wrinkles and having good feeling to users. SOLUTION: This wrinkles improver is obtained by using a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, an alkyl or (AO)m (BO)n -D-E] or formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phosphoric acid] or its acid addition salt. The wrinkles improver is useful as a cosmetic for preventing aging. The content of the active ingredient is preferably 0.001-50wt.%. An organic acid or its ester in an amount of 0.001-30wt.% is preferably further added to the system. A dicarboxylic acid is preferably used as the organic acid. The compound of formula I is obtained by reacting, e.g. a compound of formula III with a guanidination reagent.

公开(公告)号：JPH07277932A

公开(公告)日：1995-10-24

申请号：JP7189294

申请日：1994-04-11

Applicant: KAO CORP

Inventor： TANAMACHI HIROTO ,  MIYAUCHI YUUKI ,  ONO TOSHIYA ,  NAITO YUKIO ,  IMOKAWA GENJI

IPC: A61K8/00 ,  A61K8/46 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/02 ,  A61Q5/04 ,  C07C309/17 ,  C07C309/58 ,  C08L83/04 ,  A61K7/09

Abstract: PURPOSE:To obtain a composition for hair modification agent capable of correcting vicious hair easily without damaging it, and further having a good duration effect without getting the corrected hair out of shape even in a highly humid atmosphere. CONSTITUTION:A hair modification agent composition contains 0.1-10wt.%, especially l-10wt.%, of an alpha-sulfocarboxylic acid or its salt, preferably a compound of formula [each one of R and R is H, an alkali metal, an alkaline earth metal or NR R R R (each one of R5 to R8 is H, or a l-6C straight chain or branched chain alkyl which may be substituted by OH); each one of R and R is a 1-10C straight chain or branched chain alkyl or aryl, which may be substituted by OH, an alkoxy, an acyl, an acyloxy, a carboxyl or amino]. The above composition is preferred to be acidic and to be adjusted at pH2 to 7, especially at pH3 to 6. And further it is preferable to combine a surfactant, a silicone and/or a cationic polymer to the above composition to improve feelings at and after use.