中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

93 records (took 0.035 seconds)

    INHIBITORS OF SERINE PROTEASES
    11.
    发明专利
    INHIBITORS OF SERINE PROTEASES 未知

    公开(公告)号：NZ579295A

    公开(公告)日：2012-03-30

    申请号：NZ57929508

    申请日：2008-02-20

    Applicant: VERTEX PHARMA

    Inventor： FARMER LUC ,  BETHIEL RANDY SCOTT ,  JACOBS DYLAN ,  PERNI ROBERT B ,  MAXWELL JOHN ,  COTTRELL KEVIN ,  HALAS SUMMER

    IPC: C07D487/10 ,  A61K31/407 ,  A61P31/12 ,  C07D498/10

    Abstract: Disclosed are spiro compounds of formula I or pharmaceutically acceptable salts thereof, and methods for their synthesis. Specific examples of compounds of formula I include: (5S,8S)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxamide, (5R,8S)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxamide, Cyclopentyl-(S)-1-((3S,5R)-3-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-ylcarbamoyl)-8-oxo-7-phenyl-2,7-diazaspiro[4.4]nonan-2-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate, and Cyclopentyl (S)-1-((3S,5S)-3-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-ylcarbamoyl)-8-oxo-7-phenyl-2,7-diazaspiro[4.4]nonan-2-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate. Also disclosed is the use of compounds of formula I for treating a hepatitis C virus (HCV) infection.

    INHIBIDORES DE SERINA PROTEASAS.
    16.
    发明专利
    INHIBIDORES DE SERINA PROTEASAS. 未知

    公开(公告)号：MX2008001528A

    公开(公告)日：2008-04-04

    申请号：MX2008001528

    申请日：2006-08-01

    Applicant: VERTEX PHARMA

    Inventor： PERNI ROBERT B ,  LYONS STEVE

    IPC: C07D403/12 ,  A61K31/501 ,  A61P31/12

    Abstract: La invencion se refiere a compuestos de la formula (I): (ver formula) o una sal farmaceuticamente aceptable o mezclas de los mismos en donde C* representa un carbono diaestereomerico que comprende una mezcla de isomeros R y S en donde el isomero R es mayor al 50% de la mezcla.

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
    20.
    发明专利
    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease 未知

    公开(公告)号：ZA200601420B

    公开(公告)日：2007-06-27

    申请号：ZA200601420

    申请日：2004-07-16

    Applicant: VERTEX PHARMA

    Inventor： BRITT SHAWN D ,  COTTRELL KEVIN M ,  PERNI ROBERT B ,  JANOS PITLIK

    IPC: A61K20090101 ,  A61P20090101 ,  A61P31/12 ,  C07K20090101 ,  C07K7/06

    Abstract: The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.

Patent Agency Ranking