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公开(公告)号：RS57969B1
公开(公告)日：2019-01-31
申请号：RSP20181387
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：CA2927631A1
公开(公告)日：2015-04-23
申请号：CA2927631
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , O'NEIL SIMON ADAM , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , STAVROPOULOS KATHY , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME WIREDU , ZHANG YUEGANG
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：NZ772411A
公开(公告)日：2022-05-27
申请号：NZ77241116
申请日：2016-01-29
Applicant: VERTEX PHARMA , BIOMED VALLEY DISCOVERIES INC
Inventor： DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC: C07D401/04
Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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公开(公告)号：CO2021016594A2
公开(公告)日：2022-04-29
申请号：CO2021016594
申请日：2021-12-07
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , GAGNON KEVIN JAMES , HOOD SARAH CAROL , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , BANDARAGE UPUL KEERTHI , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , XU JINWANG , COTTRELL KEVIN MICHAEL , SHRESTHA MUNA , BOUCHER DIANE , CLARK MICHAEL PHILIP , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GUIDO SAMANTHA , LAI MEI-HSIU , LIU SIYING , MAXWELL BRAD , OVERHOFF KIRK ALAN , RONKIN STEVEN M , SPOSATO MARISA , STAVROPOULOS KATHY , THOMSON STEPHEN , ZAKY MARIAM
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos.
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公开(公告)号：CR20210608A
公开(公告)日：2022-02-11
申请号：CR20210608
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , GUIDO SAMANTHA , HOOD SARAH CAROL , THOMSON STEPHEN , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , KESAVAN SARATHY , MAXWELL JOHN PATRICK , OVERHOFF KIRK ALAN , STAVROPOULOS KATHY , XU JINWANG , CLARK MICHAEL PHILIP , GAGNON KEVIN JAMES , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , LOOKER ADAM , MEDEK ALES , FLEMING GABRIELLE SIMONE , HURLEY DENNIS JAMES , RONKIN STEVEN M , SHRESTHA MUNA , JONES PETER , BOUCHER DIANE , BRODNEY MICHAEL AARON , GARCIA BARRANTES PEDRO MANUEL , NUHANT PHILIPPE MARCEL , HALL AMY BETH , RODAY SETU , SAWANT RUPA , SPOSATO MARISA , BANDARAGE UPUL KEERTHI , JOHNSON JR MAC ARTHUR , LAI MEI-HSIU , MAXWELL BRAD , SWETT REBECCA JANE , ZAKY MARIAM , COTTRELL KEVIN MICHAEL , GREY JR RONALD LEE , LIU SIYING , ROEPER STEFANIE , TANG QING , TAPLEY TIMOTHY LEWIS , SHI YI
IPC: A61K31/429 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos
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Patent Agency Ranking
公开(公告)号：ES2837431T3
公开(公告)日：2021-06-30
申请号：ES17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL , BAEK MINSON , CLEMENS JEREMY , CLEVELAND THOMAS , FERRIS LORI , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HADIDA RUAH SARA , HSIA CLARA , HUGHES ROBERT , JOSHI PRAMOD , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL , MCCARTNEY JASON , MILLER MARK , PARASELLI PRASUNA , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , SIESEL DAVID , STAVROPOULOS KATHY , TERMIN ANDREAS , UY JOHNNY , VAN GOOR FREDRICK , YOUNG TOMOTHY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Un compuesto que tiene la fórmula siguiente: **(Ver fórmula)** una sal farmacéuticamente aceptable del mismo, o un derivado deuterado de cualquiera de los anteriores.
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公开(公告)号：HUE051275T2
公开(公告)日：2021-03-01
申请号：HUE18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: A61P35/00
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公开(公告)号：NZ719163A
公开(公告)日：2021-01-29
申请号：NZ71916314
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA , MUDUNURI PRAVEEN , WALDO MICHAEL , NTI-ADDAE KWAME , O’NEIL SIMON , ZHANG YUEGANG , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. The co-crystals of (S)-N-methyl-8-(1-((2’-methyl-[4,5’-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide with adipic acid are DNA-dependent protein kinase (DNA-PK) inhibitors which may be useful for the treatment of cancer.
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公开(公告)号：CA3140039A1
公开(公告)日：2020-12-10
申请号：CA3140039
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：RS60426B1
公开(公告)日：2020-07-31
申请号：RSP20200607
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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