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公开(公告)号：BRPI1012549A2
公开(公告)日：2016-03-22
申请号：BRPI1012549
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： GOOR FREDRICK F VAN , ZLOKARNIK GREGOR , BOTFIELD MARTYN C , GROOTENHUIS PETER D J , RUAH SARA S HADIDA , YANG XIAOQING
IPC: A61K31/47 , A61P3/00 , C07D215/233
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公开(公告)号：SG10201504084QA
公开(公告)日：2015-06-29
申请号：SG10201504084Q
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 2; in the presence of a coupling agent.
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公开(公告)号：HK1165803A1
公开(公告)日：2012-10-12
申请号：HK12106626
申请日：2012-07-06
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D20060101
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公开(公告)号：SG178337A1
公开(公告)日：2012-03-29
申请号：SG2012009080
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：CA2796642A1
公开(公告)日：2011-10-27
申请号：CA2796642
申请日：2011-04-22
Applicant: VERTEX PHARMA
Inventor： VAN GOOR FREDRICK F , ALARGOVA ROSSITZA GUEORGUIEVA , ALCACIO TIM EDWARD , AREKAR SNEHA G , JOHNSTON STEVEN C , KADIYALA IRINA NIKOLAEVNA , KESHAVARZ-SHOKRI ALI , KRAWIEC MARIUSZ , LEE ELAINE CHUNGMIN , MEDEK ALES , MUDUNURI PRAVEEN , SULLIVAN MARK JEFFREY , ZAMAN NOREEN TASNEEM , ZHANG BEILI , ZHANG YUEGANG , ZLOKARNIK GREGOR
IPC: A61K31/4704 , A61K31/404 , A61K31/443
Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
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Patent Agency Ranking
公开(公告)号：DK1140888T3
公开(公告)日：2003-08-25
申请号：DK99965226
申请日：1999-12-10
Applicant: VERTEX PHARMA SAN DIEGO LLC
Inventor： MAKINGS LEWIS , ZLOKARNIK GREGOR
IPC: G01N37/00 , A61K45/00 , A61P43/00 , C07D219/06 , C07D265/38 , C07D311/16 , C07D311/82 , C07D493/10 , C12Q1/26
Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; L is selected from the group of (-OCR 2 H) p -, wherein for each p, all R 2 are separately selected from the group consisting of a hydrogen atom, saturated C 1 -C 20 alkyl, unsaturated C 1 -C 20 alkenyl, unsaturated C 1 -C 20 alkynyl, substituted saturated C 1 -C 20 alkyl, substituted unsaturated C 1 -C 20 alkenyl, substituted unsaturated C 1 -C 20 alkynyl, C 1 -C 20 cycloalkyl, C 1 -C 20 cycloalkenyl, substituted saturated C 1 -C 20 cycloalkyl, substituted unsaturated C 1 -C 20 cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and p is a positive integer no greater than twelve; and Q is a chemical moiety that gives rise to optical properties in its hydroxy or hydroxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form. Most preferably, p is one, R 2 is hydrogen, and Q is the ether form of a phenoxide fluorophore.
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公开(公告)号：CY1121572T1
公开(公告)日：2020-05-29
申请号：CY191100385
申请日：2019-04-08
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: ΗπαρούσαεφεύρεσηαφοράσεφαρμακευτικέςσυνθέσειςπουπεριλαμβάνουνδιασποράστερεούτουΝ-[2,4-Δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3 καρβοξαμιδίου, μεθόδουςβιομηχανικήςκατασκευήςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσηςκαιμεθόδουςχορήγησηςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσης.
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公开(公告)号：SI2464337T1
公开(公告)日：2019-05-31
申请号：SI201031871
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：HRP20190660T1
公开(公告)日：2019-05-31
申请号：HRP20190660
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：LT2408749T
公开(公告)日：2018-09-25
申请号：LT10710748
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： YANG XIAOQING , HADIDA RUAH SARA , GROOTENHUIS PETER , VAN GOOR FREDRICK , BOTFIELD MARTYN , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/47 , A61P3/00
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