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公开(公告)号：CZ20023529A3
公开(公告)日：2003-02-12
申请号：CZ20023529
申请日：2001-03-21
Applicant: ABBOTT LAB
Inventor： DICKMAN DANIEL A , CHEMBURKAR SANJAY , FORT JAMES J , HENRY RODGER F , LECHUGA-BALLESTEROS DAVID , NIU YUPING , PORTER WILLIAM
IPC: A61K20060101 , A61K31/513 , A61P20060101 , A61P31/18 , A61P43/00 , C07D20060101 , C07D239/10
Abstract: New crystalline forms of lopinavir are disclosed.
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公开(公告)号：SK14832002A3
公开(公告)日：2003-02-04
申请号：SK14832002
申请日：2001-03-21
Applicant: ABBOTT LAB
Inventor： DICKMAN DANIEL A , CHEMBURKAR SANJAY , FORT JAMES J , HENRY RODGER F , LECHUGA-BALLESTEROS DAVID , NIU YUPING , PORTER WILLIAM
IPC: A61K20060101 , A61K31/513 , A61P20060101 , A61P31/18 , A61P43/00 , C07D20060101 , C07D239/10 , C07D239/00
Abstract: New crystalline forms of lopinavir are disclosed.
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公开(公告)号：PT882024E
公开(公告)日：2002-07-31
申请号：PT96944941
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： NORBECK DANIEL W , HANNICK STEVEN M , SHAM HING LEUNG , COOPER ARTHUR J , LIU JIH-HUA , CHEN XIAORU , TIEN JIEN-HEH J , KEMPF DALE J , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , BETEBENNER DAVID A , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , DICKMAN DANIEL A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , PATEL KETAN M
IPC: A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , C07D253/00 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , A01N47/14
Abstract: A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
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公开(公告)号：PE20011232A1
公开(公告)日：2001-12-08
申请号：PE2001000299
申请日：2001-03-30
Applicant: ABBOTT LAB
Inventor： DICKMAN DANIEL A , CHEMBURKAR SANJAY , HENRY RODGER F , NIU YUPING , PORTER WILLIAM , LECHUGA-BALLESTEROS DAVID , FORT JAMES J
IPC: A61K20060101 , A61K31/513 , A61P20060101 , A61P31/18 , A61P43/00 , C07D20060101 , C07D239/00 , C07D239/10
Abstract: SE REFIERE A LA FORMA CRISTALINA HIDRATADA O SOLVATADA DE LOPINAVIR (2S,3S,5S)-2-(2,6-DIMETILFENOXIACETIL)AMIN-3-HIDROXI-5-(2-(1-TETRAHIDROPIRIMID-2-ONIL)-3-METILBUTANOL)AMIN-1,6-DIFENILHEXANO) DE FORMULA I CARACTERIZADA POR PRESENTAR UN ESPECTRO INFRARROJO; UN PATRON DE DIFRACCION DE RAYOS X. EL LOPINAVIR ES UN INHIBIDOR DE PROTEASA DEL VIH
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公开(公告)号：AU1369001A
公开(公告)日：2001-03-22
申请号：AU1369001
申请日：2001-01-12
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , PATEL KETAN M
IPC: A61K31/415 , C07D207/26 , C07D207/40 , C07D233/32 , C07D239/10 , C07D239/22 , C07D241/08 , C07D263/22
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Patent Agency Ranking
公开(公告)号：CA2174548A1
公开(公告)日：1995-05-11
申请号：CA2174548
申请日：1994-10-21
Applicant: ABBOTT LAB
Inventor： RATAJCZYK JAMES D , CHEMBURKAR SANJAY R , KU YI-YIN , PATEL RAMESH R , BUSSE JULIETTE K , DICKMAN DANIEL A , PATEL HEMANTKUMAR , SAWICK DAVID P
IPC: A61K31/38 , A61K31/381 , A61P29/00 , A61P37/08 , A61P43/00 , B01J27/13 , B01J31/22 , C07D307/52 , C07D333/20 , C07D333/24 , C07D307/54
Abstract: A process for preparing a compound of structure (I), where A is oxygen and sulfur and R1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula (II), where X is bromine or iodine, with an Nhydroxyurea compound of formula (III), in the presence of a palladium catalyst. The compounds of formula (I) are inhibitors of the enzyme 5lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.
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公开(公告)号：BRPI0110101B1
公开(公告)日：2016-08-23
申请号：BR0110101
申请日：2001-09-20
Applicant: ABBOTT LAB , ABBVIE INC
Inventor： KUNZER AARON R , PETROS ANDREW M , DICKMAN DANIEL A , NETTESHEIM DAVID G , AUGERI DAVID J , DING HONG , DINGES JURGEN , WENDT MICHAEL D , BRUNCKO MILAN , HAJDUK PHILIP J , ROSENBERG SAUL H , THOMAS SHEELA A , FESIK STEPHEN W , BAUMEISTER STEVEN A , OOST THORSTEN , SHEN WANG , MCCLELLAN WILLIAM , WANG XILU
IPC: C07C311/00 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
Abstract: "n-acil-sulfonamidas promotoras de apoptose". descreve-se n-benzoil-aril-sulfonamidas que têm a fórmula (i), são inibidores de bcl-x1, e úteis para promover apoptose. descreve-se também composições e métodos inibidores de bcl-xl para promover apoptose em um mamífero.
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公开(公告)号：CA2612260C
公开(公告)日：2013-10-29
申请号：CA2612260
申请日：2006-07-07
Applicant: ABBOTT LAB
Inventor： WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
IPC: C07C63/64 , A61K31/192 , A61P35/00
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.
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公开(公告)号：CZ300131B6
公开(公告)日：2009-02-18
申请号：CZ20014528
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , PATEL KETAN M
IPC: C07C309/63 , C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/00 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: Zpusob prípravy slouceniny vzorce X, nebo její soli nebo esteru, kde R.sub.3.n. je C.sub.1.n.-C.sub.6.n.alkyl, hydroxy-C.sub.1.n.-C.sub.6.n.alkyl nebo C.sub.3.n.-C.sub.8.n.cykloalkyl-C.sub.1.n.-C.sub.6.n.alkyl, pri nemž se a) sloucenina vzorce XIV nebo její sul nebo ester, kde R.sub.3.n. má výše uvedený význam a Q je odstupující skupina vybraná ze skupiny zahrnující Cl, Br, I, methansulfonát, trifluormethansulfonát, p-toluensulfonát a benzensulfonát, nechá reagovat s bází, nebo b) sloucenina vzorce XVI nebo její sul nebo ester, kde R.sub.3.n. má výše uvedený význam, se nechá reagovat s karbonylovým ekvivalentem Q'-C(O)-Q'', kde Q'a Q'' jsou Cl, Br, I, C.sub.1.n.-C.sub.6.n.alkoxy, -O-aryl nebo imidazolyl, nebo c) sloucenina vzorce XIX, kde R.sub.3.n. má výše uvedený význam a R.sub.30.n.je C.sub.1.n.-C.sub.6.n.alkyl, fenyl nebo halogen-C.sub.1.n.-C.sub.6.n.alkyl, se hydrogenuje.
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公开(公告)号：MX2007016070A
公开(公告)日：2008-03-10
申请号：MX2007016070
申请日：2006-07-07
Applicant: ABBOTT LAB
Inventor： WENDT MICHAEL D , DICKMAN DANIEL A , DING HONG , ELMORE STEVEN W , SHEN WANG , THOMAS SHEELA A , AUGERI DAVID
IPC: A61K31/192 , A61P35/00 , C07C15/12
Abstract: Se describen compuestos que inhiben la actividad de la proteina Mcl-1 anti-apoptotica, las composiciones conteniendo los compuestos y metodos para el tratamiento de enfermedades durante las cuales se expresa la proteina Mcl-1.
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