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公开(公告)号：CA2711159A1
公开(公告)日：2009-07-16
申请号：CA2711159
申请日：2009-01-02
Applicant: ABBOTT LAB
Inventor： PERNER RICHARD J , KORT MICHAEL E , DIDOMENICO STANLEY JR , CHEN JUN , VASUDEVAN ANIL
IPC: C07D213/53 , A61K31/4406 , A61P29/00 , C07D215/12 , C07D217/14 , C07D333/20
Abstract: Compounds of formula (I), wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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公开(公告)号：BRPI0413305A
公开(公告)日：2006-10-10
申请号：BRPI0413305
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PENNER RICHARD J , SCHMIDT ROBERT G JR , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU , LEE CHIH-HUNG
IPC: C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D405/12 , C07D521/00 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , R 6 , R 7 , R 8a , R 8b , R 9 , Z 1 , Z 2 and L are as defined in the description.
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公开(公告)号：AT134373T
公开(公告)日：1996-03-15
申请号：AT90909264
申请日：1990-05-22
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , DEBERNARDIS JOHN F , BASHA FATIMA Z , MEYER MICHEAL D , DE BISWANATH , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D409/04 , C07D311/74 , C07D487/00 , C07D209/56 , C07D211/00 , C07C69/76 , A01N43/32
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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公开(公告)号：MX2010004495A
公开(公告)日：2010-05-05
申请号：MX2010004495
申请日：2008-10-25
Applicant: ABBOTT LAB
Inventor： VASUDEVAN ANIL , KORT MICHAEL E , BAYBURT EROL K , KOENIG JOHN R , SCHMIDT ROBERT G , DIDOMENICO STANLEY JR , GOMTSYAN ARTHUR R , PERNER RICHARD J , DAANEN JEROME F , KYM PHILIP R , VOIGHT ERIC
IPC: C07D263/48 , A61K31/421 , A61P29/00 , C07D413/04 , C07D413/12
Abstract: Se describen compuestos de la fórmula (I), en donde R1, R2, R4, y W son como se describe en la descripción y son antagonistas de TRPV1 con penetración en el sistema nervioso central (CNS). Se describen también composiciones que comprenden dichos compuestos y métodos para tratar condiciones y trastornos utilizando dichos compuestos y composiciones. (Ver fórmula I).
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公开(公告)号：CA2711408A1
公开(公告)日：2009-07-16
申请号：CA2711408
申请日：2009-01-02
Applicant: ABBOTT LAB
Inventor： PERNER RICHARD J , KORT MICHAEL E , DIDOMENICO STANLEY JR , CHEN JUN , VASUDEVAN ANIL
Abstract: Compounds of formula (I), wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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Patent Agency Ranking
公开(公告)号：CA2702976A1
公开(公告)日：2009-04-30
申请号：CA2702976
申请日：2008-10-25
Applicant: ABBOTT LAB
Inventor： PERNER RICHARD J , KOENIG JOHN R , DIDOMENICO STANLEY JR , BAYBURT EROL K , DAANEN JEROME F , GOMTSYAN ARTHUR R , KORT MICHAEL E , KYM PHILIP R , VASUDEVAN ANIL , SCHMIDT ROBERT G , VOIGHT ERIC
IPC: C07D263/48 , A61K31/421 , A61P29/00 , C07D413/04 , C07D413/12
Abstract: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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27.发明专利
公开(公告)号：ES2315704T3
公开(公告)日：2009-04-01
申请号：ES04780017
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PENNER RICHARD J
IPC: C07D217/24 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D451/02 , C07D521/00
Abstract: Un compuesto de formula (I) (Ver fórmula) o una sal farmacéuticamente aceptable del mismo, donde X1 es CR1; X2 es N; X3 es NR3; X5 es N; Z1 es O; Z2 es NH; L se selecciona del grupo que consiste en alquenileno, alquileno, alquinileno, cicloalquileno, -(CH2)mO(CH2)n-, y N(RY), donde el extremo izquierdo de -(CH2)mO(CH2)n- está unido a Z2 y el extremo derecho está unido a R9; m y n son cada uno independientemente 0-6; RY se selecciona del grupo que consiste en hidrógeno y alquilo; R1, R3, R5, R6, y R7 se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, alquenilo, alcoxi, alcoxialcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquilcarbonilo, alquilcarbonilalquilo, alquil-carboniloxi, alquiltio, alquinilo, carboxi, carboxialquilo, ciano, cianoalquilo, cicloalquilo, cicloalquilalquilo, formilo, formilalquilo, haloalcoxi, haloalquilo, haloalquiltio, halógeno, hidroxi, hidroxialquilo, mercapto, mercaptoalquilo, nitro, (CF3)2(HO)C-, -NRAS(O)2RB, -S(O)2ORA, -S(O)2RB, -NZAZB, (NZAZB)alquilo, (NZAZB)carbonilo, (NZAZB)carbonilalquilo y (NZAZB)sulfonilo, donde ZA y ZB se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, alquilo, alquilcarbonilo, formilo, arilo, y arilalquilo; RA se selecciona del grupo que consiste en hidrógeno y alquilo; RB se selecciona del grupo que consiste en alquilo, arilo, y arilalquilo; R8a se selecciona del grupo que consiste en hidrógeno y alquilo; R9 se selecciona del grupo que consiste en arilo y heterociclo; donde...
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28.发明专利
公开(公告)号：MXPA06001396A
公开(公告)日：2007-02-13
申请号：MXPA06001396
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , LEE CHIH-HUNG , KOENIG JOHN R , ZHENG GUO ZHU , TURNER SEAN C , WHITE TAMMIE K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , PENNER RICHARD J , SCHMIDT ROBERT G JR
IPC: C07D217/24 , A61K31/5377 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D451/02 , C07D521/00
Abstract: Ver formula (I) Los compuestos de la Formula (I) son novedosos antagonistas de VR1, que son utiles en el tratamiento de dolor, hiperalgesia termica inflamatoria, incontinencia urinaria, e hiperactividad de la vejiga.
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公开(公告)号：GR1001138B
公开(公告)日：1993-04-28
申请号：GR90100423
申请日：1990-05-31
Applicant: ABBOTT LAB
Inventor： BASHA FATIMA Z , BISWANATH DE , CAMPBELL JAMES R , DEBERNARDIS F JOHN , DENINNO P MICHAEL , DIDOMENICO STANLEY JR , EHRLICH P PAUL , HSIAO W CHI-NUNG , KEBABIAN W JOHN , LINDA M LIJEWSKI , MARTIN C YVONNE , MEYER D MICHAEL
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07C235/08 , C07C235/18 , C07C217/58 , C07C215/50 , C07C237/22
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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公开(公告)号：GR900100423A
公开(公告)日：1991-10-10
申请号：GR90100423
申请日：1990-05-31
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , MARTIN YVONNE C , PERNER RICHARD J , HSIAO CHI-NUNG W , DEBERNARDIS JOHN F , MEYER MICHAEL D , EHRLICH PAUL P , MORTON HOWARD E , KEBABIAN JOHN W , DENINNNO MICHAEL P , STOUT DAVID M , DIDOMENICO STANLEY JR , BASHA FATIMA Z DE
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07C235/08 , C07C235/18 , C07C217/58 , C07C215/50 , C07C237/22
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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