公开(公告)号：AU9381801A

公开(公告)日：2002-03-26

申请号：AU9381801

申请日：2001-09-17

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS

IPC: C12P9/00

公开(公告)号：ID29136A

公开(公告)日：2001-08-02

申请号：ID20010881

申请日：1999-10-13

Applicant: BASF AG

Inventor： RESS-LOSCHKE MARION ,  FRIEDRICH THOMAS ,  HAUER BERNHARD ,  MATTES RALF ,  ENGELS DIRK

IPC: C07H21/00 ,  C12N1/21 ,  C12N9/78 ,  C12N15/55 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05 ,  C12N15/09 ,  C12N15/63

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

公开(公告)号：BR9914629A

公开(公告)日：2001-06-26

申请号：BR9914629

申请日：1999-10-13

Applicant: BASF AG

Inventor： RESS LOSCHKE MARION ,  FRIEDRICH THOMAS ,  HAUER BERNHARD ,  MATTES RALF ,  ENGELS DIRK

IPC: C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N9/78 ,  C12N15/55 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05 ,  C12N15/63

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

公开(公告)号：CA2389064A1

公开(公告)日：2001-05-10

申请号：CA2389064

申请日：2000-10-20

Applicant: BASF AG

Inventor： KESSELER MARIA ,  MATTES RALF ,  FRIEDRICH THOMAS ,  HAUER BERNHARD

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P17/04 ,  C12P41/00 ,  C12R1/19

Abstract: The invention relates to proteins which have an enzymatic activity for hydrolysing L-pantolactone. The invention also relates to nucleic acids that code for these proteins, to nucleic acid constructs, to vectors, to genetically modified micro-organisms and to a method for producing D- pantolactone.

公开(公告)号：AT200152T

公开(公告)日：2001-04-15

申请号：AT97935554

申请日：1997-07-30

Applicant: BASF AG

Inventor： FUCHS HARALD ,  FRIEDRICH THOMAS ,  SCHREPP WOLFGANG

IPC: G01N33/543 ,  G01Q60/20

Abstract: Verfahren zum Wirkstoff-Screening, wobei man den Wirkstoff über die mittels einer rasteroptischen Nahfeldmikroskopiervorrichtung (SNOM-Vorrichtung) beobachtbare Änderung eines Signals (S) nachweist, sowie dafür geeignete Einrichtung, umfassend die SNOM-Vorrichtung, eine Einzel- oder Mehrfachprobenaufnahmevorrichtung und eine Steuereinrichtung.

公开(公告)号：DE19838189A1

公开(公告)日：2000-03-02

申请号：DE19838189

申请日：1998-08-24

Applicant: BASF AG

Inventor： BEWERT WOLFGANG ,  BETZ ROLAND ,  LUEDDECKE ERIK ,  FRIEDRICH THOMAS

IPC: A23J3/00 ,  A23K1/16 ,  A23K20/174 ,  A23K20/179 ,  A23L1/305 ,  A23L33/15 ,  A23L33/155 ,  A61K9/16 ,  A61K47/48 ,  A23L1/30 ,  A23P1/04 ,  A23P1/06

公开(公告)号：CZ247798A3

公开(公告)日：1999-03-17

申请号：CZ247798

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：ZA971107B

公开(公告)日：1998-08-11

申请号：ZA971107

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K ,  A61K ,  C07H

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：CO4600682A1

公开(公告)日：1998-05-08

申请号：CO97006960

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  BOLLSCHWEILE CLAUS ,  HANS WOLGANG ,  RUBSAMEN KLAUS ,  FRIEDRICH THOMAS ,  SCHWEDEN JURGEN ,  SCHMIDT MARTIN

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/36 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91

Abstract: LA PRESENTE INVENCION SE REFIERE A NUEVAS TROMBIN MUTEINAS SU PREPARACION Y UTILIZACION COMO ANTIDOTO PARA LOS INHIBIDORES DE LA TROMBINA.

公开(公告)号：AU1768497A

公开(公告)日：1997-08-28

申请号：AU1768497

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.