公开(公告)号：DE3302442A1

公开(公告)日：1984-07-26

申请号：DE3302442

申请日：1983-01-26

Applicant: BASF AG

Inventor： THYES MARCO DR ,  ROSSY PHILLIP A DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/14

公开(公告)号：DE3302021A1

公开(公告)日：1984-07-26

申请号：DE3302021

申请日：1983-01-22

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：DE3229539A1

公开(公告)日：1984-02-09

申请号：DE3229539

申请日：1982-08-07

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ DR ,  NEUMANN PETER DR ,  LENKE DIETER PROF DR ,  FRIEDRICH LUDWIG DR

IPC: A61K31/24 ,  A61K31/44 ,  A61K31/4402 ,  A61P37/08 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/00 ,  C07C233/02 ,  C07C233/43 ,  C07C233/56 ,  C07C253/00 ,  C07C255/58 ,  C07C255/60 ,  C07D213/75 ,  C07D267/04 ,  C07D401/04 ,  C07D413/04 ,  C07C103/34 ,  A61K31/215 ,  A61K31/395 ,  A61K31/535 ,  C07C102/00 ,  C07C103/375

公开(公告)号：DE3212794A1

公开(公告)日：1983-10-13

申请号：DE3212794

申请日：1982-04-06

Applicant: BASF AG

Inventor： STEINER GERD DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D403/12

Abstract: 5,6-Dihydro-11-methylenemorphanthridin-6-ones of the formula I I where R1, R2, R3 and R4 have the meanings given in the description, and their preparation and use. The novel substances are particularly useful for treating gastric and duodenal ulcers.

公开(公告)号：DE3226863A1

公开(公告)日：1983-04-07

申请号：DE3226863

申请日：1982-07-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  MUELLER JOSEF DIPL CHEM DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DIPL ,  HEGE HANS-GUENTHER DIPL CHEM D ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  PHILIPSBORN GERDA VON DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C97/10 ,  A61K31/135 ,  A61K31/395 ,  C07D295/10

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：DE3033702A1

公开(公告)日：1982-04-22

申请号：DE3033702

申请日：1980-09-08

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LENKE DIETER PROF DR ,  LEHMANN HANS DIETER DR MED ,  GRIES JOSEF DR MED

IPC: C07D237/04 ,  A61K31/50

Abstract: -pyridazinone derivs. (I) are new. X is O or S; R1 is H or 1-3C alkyl; and R2 is 1-8C alkyl (opt. substd. by 1-4 halogen atoms, 1-4C alkoxy (sepd. from X by at least 2 C-atoms), 3-8C cycloalkyl (opt. carrying 1 or 2 1-3C alkyl gps.) or phenyl (opt. in turn carrying 1-3 substits. from 1-3C alkyl, 1-3C alkoxy, halogen, CF3 or NO2), 3-8C cycloalkyl (opt. mono- to tetra substd. by 1-4C alkyl), 3-8C alkenyl, 3-8C alkynyl or phenyl (opt. carrying 1-3 substits. from 1-4C alkyl, 1-4C alkoxy, halogen, CF3, CN and NO2). (I) have thrombocyte aggregation inhibiting and hypotensive properties. They can be used as antihypertensive agents and for the prophylaxis and treatment of thrombo-embolid diseases. Results of tests for pharmacological activity are given in the spec.

公开(公告)号：DE3027528A1

公开(公告)日：1982-02-18

申请号：DE3027528

申请日：1980-07-19

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ DR ,  NEUMANN PETER DR ,  SEYBOLD GUENTHER DR ,  LENKE DIETER PROF DR ,  FRIEDRICH LUDWIG DR

IPC: A61K31/425 ,  A61K31/428 ,  A61P37/08 ,  C07D277/60 ,  C07D277/82 ,  C07D277/68

公开(公告)号：DE3006351A1

公开(公告)日：1981-09-17

申请号：DE3006351

申请日：1980-02-20

Applicant: BASF AG

Inventor： SCHLECKER RAINER DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  FRICKEL FRITZ-FRIEDER DIPL CHE ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: C07D213/30 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D277/24 ,  C07D307/42 ,  C07D333/16 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6553 ,  C07D271/02 ,  A61K31/34 ,  A61K31/38 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  C07D213/24 ,  C07D283/00

Abstract: 2-((3-amimo-2-hydroxypropoxy)-styryl) derivs. of formula (I) and their physiologically acceptable salts are new. (where Het is 2-furyl, 2- or 3-thienyl, 2- or 4-pyridyl, 4-thiazolyl, 4-isothiazolyl, 5-(1,2,4-oxadiazolyl) or 5-(1,3,4-oxadiazolyl), all these gps. opt. substd. by 1-4C alkyl or Ph which is itself opt. mono or disubstd by 1-3C alkyl; R is H, 1-8C alkyl (opt. substd. by OH, 1-3C alkoxy or 1-3C alkyl or 3-8 ring C cycloalkyl), 3-8 ring C cycloalkyl, opt. mono or disubstd. on the ring with 1-3C alkyl). (I) are pharmaceuticals for the treatment of hypertonia, coronary heart disease or cardiac arhythm. (I) are beta-sympatholytics which can be used in doses 15-23 times smaller than doses necessary if a similar effect is to be achieved using propranolol. (I) are of low toxicity. LD50 are 6,800-121,000 times greater than the ED50. (I) therefore have a wider therapeutic index than propranol has (only 1,030). Suitable unit doses of (I) are 1-100 (pref. 3-50) mg for humans.

公开(公告)号：DE2943405A1

公开(公告)日：1981-05-07

申请号：DE2943405

申请日：1979-10-26

Applicant: BASF AG

Inventor： FRICKER FRITZ-FRIEDER DIPL CHE ,  THIEME PETER C DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  THEOBALD HANS DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07C43/12 ,  C07C45/61 ,  C07C45/64 ,  C07C45/70 ,  C07D261/08 ,  C07F9/653

Abstract: Novel aminopropanol derivatives of 5-(2-hydroxystyryl)-isoxazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.

公开(公告)号：DE2941597A1

公开(公告)日：1981-04-23

申请号：DE2941597

申请日：1979-10-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  PHILIPSBORN GERDA VON DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.