公开(公告)号：AU2013349330C1

公开(公告)日：2019-11-14

申请号：AU2013349330

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRODER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RUDIGER ,  WEBER JAKOB

IPC: C12N15/11 ,  A01N37/00 ,  C07D307/77 ,  C12N15/63 ,  C12N15/67

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：CA2942990A1

公开(公告)日：2015-09-24

申请号：CA2942990

申请日：2015-03-18

Applicant: BASF SE

Inventor： DANTAS COSTA ESTHER ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAEFNER STEFAN ,  KRAWCZYK JOANNA MARTYNA ,  VON ABENDROTH GREGORY ,  RIEDELE CHRISTIAN ,  RENZ TORSTEN

IPC: C12P7/46 ,  C07K14/285 ,  C12N9/04 ,  C12N9/10

Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I)cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

公开(公告)号：CA2938372A1

公开(公告)日：2015-08-13

申请号：CA2938372

申请日：2015-02-05

Applicant: BASF SE

Inventor： KRAWCZYK JOANNA MARTYNA ,  HAEFNER STEFAN ,  SCHRODER HARTWIG ,  DANTAS COSTA ESTHER ,  ZELDER OSKAR ,  VON ABENDROTH GREGORY

IPC: C12N9/10 ,  C12N1/20 ,  C12P7/46

Abstract: The present invention relates to a modified microorganismhaving, compared to its wild-type, a reduced activity of the enzyme that is encoded bythe fruA-gene. The present invention also relates to a method for producing an organic compount and to the use of modified microorganisms.

公开(公告)号：CA2933650A1

公开(公告)日：2015-06-18

申请号：CA2933650

申请日：2014-12-08

Applicant: BASF SE

Inventor： SCHRODER HARTWIG ,  HARTMANN HOLGER ,  WANG QINGZHAO ,  RATANI SHAKIR ,  GUO ZHEYUAN ,  POMPEJUS MARKUS

IPC: C12N15/31 ,  C07K14/245 ,  C12N1/21 ,  C12N15/52 ,  C12N15/64 ,  C12N15/70 ,  C12P13/04 ,  C12P13/06

Abstract: Provided are a recombinant nucleic acid molecule, a recombinant microorganism, and a method for producing alanine. Also provided is the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：AU2013285476A1

公开(公告)日：2015-01-22

申请号：AU2013285476

申请日：2013-07-03

Applicant: BASF SE ,  WINTERSHALL HOLDING GMBH

Inventor： BROCKMANN BEATA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  FLECK CHRISTIAN ,  SCHRODER HARTWIG ,  GRANSTROM MARI ,  SCHMIDT JULIA KRISTIANE

IPC: C12N9/10 ,  C12P19/04

Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&bgr;-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity or the use of such a polypeptide for producing &bgr;-glucans. Furthermore, the present invention relates to methods for producing &bgr;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity into a microorganism being able to synthesize &bgr;-glucans.

公开(公告)号：ZA201307315B

公开(公告)日：2014-12-23

申请号：ZA201307315

申请日：2013-10-01

Applicant: BASF SE

Inventor： SCHRODER HARTWIG ,  HOFF BIRGIT

IPC: A61K20060101

Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.

公开(公告)号：CA2898963A1

公开(公告)日：2014-10-02

申请号：CA2898963

申请日：2014-03-03

Applicant: BASF SE

Inventor： ERNST BURKHARD ,  EHRESMANN MANFRED ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  BONNEKESSEL MELANIE ,  KAEDING THOMAS ,  SCHEIN-ALBRECHT KARIN ,  DEMMING STEFANIE ,  WEBER FRANZ ,  SIEGEL WOLFGANG ,  SCHRODER HARTWIG ,  FREYER STEPHAN ,  ODMAN PETER

IPC: C12P17/18

Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.

公开(公告)号：CA2880845A1

公开(公告)日：2014-02-27

申请号：CA2880845

申请日：2013-08-13

Applicant: BASF SE

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIME FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRODER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KORBER KARSTEN

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

公开(公告)号：CA2825979A1

公开(公告)日：2012-09-07

申请号：CA2825979

申请日：2012-02-24

Applicant: BASF SE

Inventor： SCHRODER HARTWIG ,  HOFF BIRGIT

IPC: A61K31/48

Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.

公开(公告)号：ES2328264T3

公开(公告)日：2009-11-11

申请号：ES05745555

申请日：2005-05-04

Applicant: BASF SE

Inventor： STURMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHRODER HARTWIG

IPC: C12P7/02 ,  C07D333/16 ,  C12N9/04 ,  C12P20060101 ,  C12P13/00 ,  C12P17/00

Abstract: Método para la producción de alcanoles ópticamente activos de la fórmula I ** ver fórmula** donde n representa un valor numérico entero de 0 a 5; Cyc representa un anillo carbocíclico o heterocíclico, dado el caso sustituido, mono o polinuclear, saturado o insaturado, y R 1 representa halógeno, SH, OH, NO2, NR 2 R 3 o NR 2 R 3 R 4+ X - , donde R 2 , R 3 y R 4 independientemente uno de otro representan H o un radical alquilo pequeño o alcoxi pequeño con 1 a 6 átomos de carbono y X - representa un ión contrario, donde en un medio que contiene una alcanona de la fórmula II, ** ver fórmula** donde n, Cyc y R 1 en los significados arriba indicados, se incuba una enzima (E), con una secuencia de polipéptidos (i) SEQ ID NO: 2 o (ii) en la que hasta 25% de los radicales aminoácido, respecto a SEQ ID NO:2, ha sido cambiado mediante borrado, inserción, sustitución, o una combinación de ellos, y la cual aun posee una actividad enzimática de por lo menos 50% de la de SEQ ID NO:2 en presencia de equivalentes de reducción, donde el compuesto de la fórmula II es reducido por vía enzimática hasta el compuesto de la fórmula I, y los equivalentes de reducción consumidos en el curso de la reacción son generados nuevamente por transformación de un alcohol de sacrificio hasta la correspondiente cetona de sacrificio con la ayuda de la enzima (E) y la cetona de sacrificio es eliminada al menos parcialmente del medio de reacción, y se aísla el producto formado (I).