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公开(公告)号：HRP20190373T1
公开(公告)日：2019-04-19
申请号：HRP20190373
申请日：2019-02-26
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , DENG HONGBO , WAAL NATHAN D , GU WENXIN
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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公开(公告)号：AU2014244555B2
公开(公告)日：2018-06-28
申请号：AU2014244555
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , COTTRELL KEVIN M , MORRIS MARK A , WAAL NATHAN D , COURT JOHN J , GU WENXIN , DENG HONGBO
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
Abstract: The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：SG11201507203RA
公开(公告)日：2015-10-29
申请号：SG11201507203R
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , COTTRELL KEVIN M , MORRIS MARK A , WAAL NATHAN D , COURT JOHN J , GU WENXIN , DENG HONGBO
IPC: A61K31/517 , A61P35/00 , C07D403/12 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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24.发明专利
公开(公告)号：NZ579296A
公开(公告)日：2012-10-26
申请号：NZ57929608
申请日：2008-02-27
Applicant: VERTEX PHARMA
Inventor： COTTRELL KEVIN M , MAXWELL JOHN , TANG QING , GRILLOT ANNE-LAURE , LE TIRAN ARNAUD , PEROLA EMANUELE
IPC: C07D498/10 , A61K31/24 , A61P31/12
Abstract: Disclosed are spiro compounds of formula (I), salts thereof, and methods for their preparation. A specific example of compounds of formula (I) is: 7-((S)-3-(benzo[b]thiophen-3-yl)-2-(2-cyclohexylacetamido)propanoyl)-3-(3-chlorophenyl)-N-((3R)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide, Compounds of formula (I) are useful for treating hepatitis C virus
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公开(公告)号：AU2006282771B2
公开(公告)日：2012-08-09
申请号：AU2006282771
申请日：2006-08-28
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , MAXWELL JOHN , COTTRELL KEVIN M , PEROLA EMANUELE , LE TIRAN ARNAUD , TANG QING
IPC: C07D498/10 , C07K5/08
Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.
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Patent Agency Ranking26.发明专利
公开(公告)号：CA2566461C
公开(公告)日：2012-07-10
申请号：CA2566461
申请日：2005-05-13
Applicant: VERTEX PHARMA
Inventor： MARTINEZ-BOTELLA GABRIEL , HALE MICHAEL R , MALTAIS FRANCOIS , TANG QING , STRAUB JUDITH
IPC: C07D401/04 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00 , C07F9/58 , C07F9/6558
Abstract: The present invention provides a compound of formula I: (see formula I) or a pharmaceutically acceptable salt thereof. The compound or salt may be used to inhibit ERK1 or ERK2 protein kinase activity in a biological sample in vitro or treat or lessen the severity of melanoma, breast cancer, colon cancer, pancreatic cancer, kidney carcinoma, lung cancer, ovarian cancer or prostate cancer in a patient in need thereof.
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公开(公告)号：MX2011012522A
公开(公告)日：2012-02-08
申请号：MX2011012522
申请日：2010-05-27
Applicant: VERTEX PHARMA
Inventor： TANG QING , LAUFFER DAVID , LI PAN , WAAL NATHAN , RONKIN STEVEN
IPC: C07D513/04 , A61K31/433 , A61P35/00
Abstract: La presente invención describe compuestos de fórmula (I), que son útiles en la inhibición de proteína cinasa c-Met. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden compuestos de fórmula (I) y métodos para usar las composiciones en el tratamiento de trastornos proliferativos. FORMULA (i).
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公开(公告)号：GEP20115280B
公开(公告)日：2011-09-12
申请号：GEAP2006010581
申请日：2006-08-28
Applicant: VERTEX PHARMA
Inventor： COTTRELL KEVIN M , MAXWELL JOHN , TANG QING , GRILLOT ANNE-LAURE , LE TIRAN ARNAUD , PEROLA EMANUELE
IPC: C07D498/10 , C07K5/08
Abstract: Compounds of formula (I) (I) (values R1, R2, Y, Y1, A and B are defined in the description), pharmaceutical composition comprising them and use thereof as an antiviral means to inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease and reduce or prevention of destruction (contamination) of HCV biological sample or medical or laboratory instruments.
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公开(公告)号：DE602008005786D1
公开(公告)日：2011-05-05
申请号：DE602008005786
申请日：2008-09-30
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LI PAN , WAAL NATHAN , MCGINTY KIRA , TANG QING , RONKIN STEVEN , FARMER LUC , SHANNON DEAN , JACOBS DYLAN
IPC: C07D401/14
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公开(公告)号：AT502935T
公开(公告)日：2011-04-15
申请号：AT08835773
申请日：2008-09-30
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LI PAN , WAAL NATHAN , MCGINTY KIRA , TANG QING , RONKIN STEVEN , FARMER LUC , SHANNON DEAN , JACOBS DYLAN
IPC: C07D401/14
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