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公开(公告)号：EP2782580A4
公开(公告)日：2015-10-07
申请号：EP12851734
申请日：2012-11-23
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , XU QING , BAUER SHAWN M , SONG YONGHONG , PANDEY ANJALI , DICK RYAN
IPC: A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
CPC classification number: C07H15/26 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
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32.发明公开[4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO 有权[4-（6-卤代-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基）苯基] -5-氯 - 噻吩-2-基 - 磺酰脲类和相关表格 与程序
公开(公告)号：EP1951254A4
公开(公告)日：2009-05-27
申请号：EP06827506
申请日：2006-11-03
Applicant: PORTOLA PHARM INC
Inventor： HUANG WOLIN , MEHROTRA MUKUND , ZHANG XIAOMING , CANNON HILARY , GRANT CRAIG M , SCARBOROUGH ROBERT M
IPC: C07D409/12 , A61K31/517 , A61P9/00 , A61P9/04 , A61P9/10
CPC classification number: C07D409/12
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公开(公告)号：EP1667989A4
公开(公告)日：2008-08-20
申请号：EP04785303
申请日：2004-09-29
Applicant: PORTOLA PHARM INC
Inventor： SCARBOROUGH ROBERT M , KANE-MAGUIRE KIM A , MARLOWE CHARLES K , SMYTH MARK S , ZHANG XIAOMING
IPC: C07D401/02 , A61K31/47 , A61K31/4709 , A61K31/506 , C07D217/24 , C07D401/04 , C07D409/12
CPC classification number: C07D409/14 , C07D217/24 , C07D401/04 , C07D409/12
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34.发明公开
公开(公告)号：EP1668002A4
公开(公告)日：2006-12-20
申请号：EP04789522
申请日：2004-09-29
Applicant: PORTOLA PHARM INC
Inventor： SCARBOROUGH ROBERT M , HUANG WOLIN , PANDEY ANJALI , BAUER SHAWN M , ZHANG XIAOMING , JIA ZHAOZHONG J
IPC: C07D409/12 , A61K20060101 , A61K31/517 , A61P7/02 , C07D409/14
CPC classification number: C07D409/12 , C07D409/14
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公开(公告)号：EP2900639A4
公开(公告)日：2016-04-20
申请号：EP13842615
申请日：2013-09-27
Applicant: PORTOLA PHARM INC
Inventor： PANDEY ANJALI , SONG YONGHONG , XU QING
IPC: C07D217/24 , A61K31/55 , A61P11/00 , C07D401/04 , C07D471/04
CPC classification number: C07D471/04 , C07D217/24 , C07D401/04 , C07D401/12
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Patent Agency Ranking
公开(公告)号：EP2863905A4
公开(公告)日：2015-12-16
申请号：EP13807089
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： SONG YONGHONG , XU QING , SRAN ARVINDER , BAUER SHAWN M , JIA ZHAOZHONG J , KANE BRIAN , PANDEY ANJALI
IPC: C07D401/12 , A61K31/4439 , A61K31/444 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D417/12 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
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37.发明公开
公开(公告)号：EP2863748A4
公开(公告)日：2015-12-09
申请号：EP13807456
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , ROSE JACK , BAUER SHAWN M , SONG YONGHONG , XU QING , PANDEY ANJALI
IPC: A01N43/64 , A01N43/707 , A61K31/53 , C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
CPC classification number: C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供用于抑制Syk激酶的三嗪化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及至少部分地通过Syk激酶活性介导的病症的治疗方法。
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公开(公告)号：EP1737386A4
公开(公告)日：2012-01-04
申请号：EP05736870
申请日：2005-04-18
Applicant: PORTOLA PHARM INC
Inventor： ANDRE PATRICK , PHILLIPS DAVID R , HOMCY CHARLES
IPC: A61F2/02 , A61K31/473 , A61K31/4745 , A61K31/52 , A61L31/10 , A61L31/16
CPC classification number: A61K31/473 , A61K31/4745 , A61K31/52 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/434
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39.发明公开USE OF TP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS IN ASPIRIN SENSITIVE AND OTHER POPULATIONS 审中-公开TP调节剂用于治疗心血管疾病的阿司匹林敏感数据和其它人群治疗
公开(公告)号：EP2144999A4
公开(公告)日：2010-06-16
申请号：EP08747593
申请日：2008-05-02
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , HOMCY CHARLES J
CPC classification number: A61K31/422 , A61K31/20 , A61K31/405 , A61K31/4406 , A61K31/444 , A61K45/06
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公开(公告)号：EP3182993A4
公开(公告)日：2018-01-17
申请号：EP15834421
申请日：2015-08-20
Applicant: PORTOLA PHARM INC
Inventor： WANG JUAN , SACHA GREGORY A , NGUYEN PHUONG M
CPC classification number: C12N9/6432 , A61K9/0019 , A61K9/19 , A61K38/4846 , A61K47/183 , A61K47/26 , C07K14/00 , C12Y304/21006
Abstract: The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation suitable for lyophilization can include a fXa antidote, a solubilizing agent, a stabilizer, and a crystalline component, wherein the formulation does not collapse during lyophilization.
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