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    신규의 2,4-디플루오로벤즈아미드 유도체
    31.
    发明公开
    신규의 2,4-디플루오로벤즈아미드 유도체 失效
    新的2,4-二氟硼酸衍生物

    公开(公告)号：KR1020030001167A

    公开(公告)日：2003-01-06

    申请号：KR1020010037547

    申请日：2001-06-28

    Applicant: 동화약품주식회사

    Inventor： 정용호 ,  이치우 ,  양왕용 ,  이학동 ,  박휘정 ,  장윤영 ,  이진수

    IPC: C07D401/12

    CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D401/12 ,  C07D403/12

    Abstract: PURPOSE: Provided are novel 2,4-difluorobenzamide derivatives which are excellent in inhibition of the growth of both HBV and HCV, and thus used as prevention and treatment agents for HBV hepatitis and HCV hepatitis. also, provided are their pharmaceutically acceptable salts and their manufacturing method. CONSTITUTION: The 2,4-difluorobenzamide derivative is represented by the formula(1), wherein R1 is C1-C4 linear or branched alkyl group, hydroxy group, a C2-C6 alkylamino group, a 4-sulfamoylphenyl group, or a saturated or unsaturated 5 or 6 membered hetero cycle having 1-2 of hetero atoms selected from N, O and S; R2 is H or a C1-C3 linear or branched alkyl group; or R1 and R2 are bound together with 1-2 of hetero atoms selected from N, O and S to form a saturated or unsaturated 5, 6 or 7 membered hetero cycle, wherein the hetero cycle is a C1-C4 linear or branched alkyl group, or substituted or unsubstituted with a C1-C3 hydroxyalkyl group; and R3 is a 5-indazolyl group; and n is an integer of 0-4.

    Abstract translation: 目的：提供对HBV和HCV的生长抑制优异的新型2,4-二氟苯甲酰胺衍生物，因此用作HBV肝炎和HCV肝炎的预防和治疗剂。 还提供了它们的药学上可接受的盐及其制造方法。 构成：2,4-二氟苯甲酰胺衍生物由式（1）表示，其中R1是C1-C4直链或支链烷基，羟基，C2-C6烷基氨基，4-氨磺酰基苯基或饱和或 具有1-2个选自N，O和S的杂原子的不饱和5或6元杂环; R2是H或C1-C3直链或支链烷基; 或R 1和R 2与1-2个选自N，O和S的杂原子结合在一起以形成饱和或不饱和的5,6或7元杂环，其中杂环是C 1 -C 4直链或支链烷基 或者被C1-C3羟烷基取代或未取代; 并且R 3是5-吲唑基; n为0-4的整数。

    정향 에탄올 추출물의 용매 분획물을 유효성분으로 함유하는 고지혈증 예방 및 치료용 지질개선제
    38.
    发明公开
    정향 에탄올 추출물의 용매 분획물을 유효성분으로 함유하는 고지혈증 예방 및 치료용 지질개선제 无效
    预防高脂血症和固化脂质体改良剂含有溶血性脂肪分解物的提取物

    公开(公告)号：KR1020120114790A

    公开(公告)日：2012-10-17

    申请号：KR1020110032546

    申请日：2011-04-08

    Applicant: 동화약품주식회사

    Inventor： 이진수 ,  성승규 ,  노양국 ,  염지현 ,  오성준 ,  이창준 ,  박다애 ,  장환봉

    IPC: A61K36/61 ,  A61P3/06 ,  A61P3/00

    CPC classification number: A61K36/61 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K2236/33

    Abstract: PURPOSE: A lipid improving agent for prevention and treating hyperlipidemia which contains solvent fraction of caryophylli flos ethanol extracts is provided to enhance ACAT enzyme inhibition effects. CONSTITUTION: A lipid improving agent for prevention and treating hyperlipidemia contains Caryophylli Flos ethylacetate fraction as an active ingredient. The Caryophylli Flos ethylacetate fraction is obtained by the following steps: extracting the Caryophylli Flos as ethanol at the room temperature and concentrating at 60 deg. Or less and suspends in water; solvent extracting the suspended solution using hexane and removing the separated hexane layer; solvent extracting the remaining water layer by using the methylene chloride solvent and isolating and removing the methylenechloride layer; isolation extracting the remaining water layer by using ethylacetate solvent and separating the ethylacetate layer and compressing and concentrating thereof at 60 deg. Celsius or less. [Reference numerals] (AA) Caryophylli flos; (BB) 95% ethanol; (CC) Caryophylli flos 95% ethanol extract(comparative example 1); (DD) Water; (EE) Suspended solution; (FF) Hexane; (GG) Hexane layer(comparative example 2); (HH, KK, NN) Water layer; (II) Methylenechloride; (JJ) Methylenechloride layer(comparative example 3); (LL) Ethyl acetate; (MM) Ethyl acetate layer(practical example 1); (OO) Butanol; (PP) Butanol layer(comparative example 4); (QQ) Water layer(comparative example 5)

    Abstract translation: 目的：提供一种用于预防和治疗含有caryophylli flos乙醇提取物的溶剂级分的高脂血症的脂质改善剂，以增强ACAT酶的抑制作用。 构成：用于预防和治疗高脂血症的脂质改善剂含有Caryophylli Flos乙酸乙酯部分作为活性成分。 通过以下步骤获得Caryophylli Flos乙酸乙酯级分：在室温下将Caryophylli Flos作为乙醇提取，并在60℃浓缩。 或更少，并在水中暂停; 溶剂用己烷萃取悬浮溶液，除去分离的己烷层; 溶剂通过使用二氯甲烷溶剂萃取剩余的水层并分离和除去二氯甲烷层; 通过使用乙酸乙酯溶剂分离萃取剩余的水层并分离乙酸乙酯层并在60℃压缩并浓缩。 摄氏度以下。 （附图标记）（AA）Caryophylli flos; （BB）95％乙醇; （CC）Caryophylli flos 95％乙醇提取物（比较例1）; （DD）水; （EE）悬浮溶液; （FF）己烷; （GG）己烷层（比较例2）。 （HH，KK，NN）水层; （二）亚甲基氯; （JJ）亚甲基氯化物层（比较例3）; （LL）乙酸乙酯; （MM）乙酸乙酯层（实施例1）; （OO）丁醇; （PP）丁醇层（比较例4）; （QQ）水层（比较例5）

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