公开(公告)号：NO20024678L

公开(公告)日：2002-09-30

申请号：NO20024678

申请日：2002-09-30

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG ,  KURUKULA-SURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C231/02

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

公开(公告)号：NO20024678A

公开(公告)日：2002-09-30

申请号：NO20024678

申请日：2002-09-30

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG ,  KURUKULA-SURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C231/02

CPC classification number: C07D233/74 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28

公开(公告)号：AU9213698A

公开(公告)日：1999-03-29

申请号：AU9213698

申请日：1998-09-01

Applicant: ABBOTT LAB

Inventor： HILL DAVID R

IPC: C07H1/00 ,  C07H17/08

Abstract: Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6-O-alkyl erythromycin.

公开(公告)号：PL2307393T3

公开(公告)日：2013-09-30

申请号：PL09767695

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S II ,  HILL DAVID R ,  HAIGHT ANTHONY R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/13 ,  C07D295/155

公开(公告)号：DK2307393T3

公开(公告)日：2013-07-15

申请号：DK09767695

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S II ,  HILL DAVID R ,  HAIGHT ANTHONY R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/13 ,  C07D295/155

公开(公告)号：MX2010014224A

公开(公告)日：2011-01-21

申请号：MX2010014224

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： WANG LEI ,  YU SU ,  HAIGHT ANTHONY R ,  FRANCZYK THADDEUS S II ,  HILL DAVID R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  MEI JIANZHANG

IPC: C07D295/155

Abstract: Se describe un proceso para la preparación del promotor de apoptosis N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1 -il)metil)piperazinil-1-iI)benzoilo)-4-(((1R)-3-(morfolin-4-iI)-1 -((fenil) metil) propil) amino)-3-(trifluorometil)sulfonil)bencens ulfonamida (ABT-263). De la fórmula (I).

公开(公告)号：CA2375364C

公开(公告)日：2008-11-25

申请号：CA2375364

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： MCLAUGHLIN MAUREEN A ,  HAIGHT ANTHONY R ,  MORTON HOWARD E ,  PETERSON MATTHEW J ,  GRIEME TIM ,  RILEY DAVID ,  DESHPANDE MAHENDRA N ,  WITTENBERGER STEVEN J ,  NAPIER JAMES J ,  TIEN JIEN-HEH J ,  RAJE PRASAD S ,  PLATA DANIEL J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  KING STEVEN A ,  RASMUSSEN MICHAEL ,  STONER ERIC J ,  HSU MARGARET CHI-PING ,  LEE ELAINE C ,  LEANNA MARVIN R ,  HILL DAVID R

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07B61/00 ,  C07H1/00

Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates t o processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：ZA200206049B

公开(公告)日：2003-12-22

申请号：ZA200206049

申请日：2002-07-29

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  KURUKULASURIYA RAVI ,  HSIAO CHI-NUNG ,  WITTENBERGER STEVEN J

IPC: C07C20060101 ,  C07D20060101 ,  C07C ,  C07D

公开(公告)号：DK1015466T3

公开(公告)日：2003-09-01

申请号：DK98944641

申请日：1998-09-01

Applicant: ABBOTT LAB

Inventor： HILL DAVID R

IPC: C07H1/00 ,  C07H17/08

Abstract: Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6-O-alkyl erythromycin.

公开(公告)号：BG107145A

公开(公告)日：2003-05-30

申请号：BG10714502

申请日：2002-09-24

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG W ,  KURUKULASURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C231/02

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines. 11 claims