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公开(公告)号：NO996579D0
公开(公告)日：1999-12-30
申请号：NO996579
申请日：1999-12-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：CA2277121A1
公开(公告)日：1998-07-16
申请号：CA2277121
申请日：1998-01-07
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , FLORJANCIC ALAN SCOTT , STEINMAN DOUGLAS H , GUO YAN , HOLMS JAMES H , SHEPPARD GEORGE S , XU LIANHONG , MICHAELIDES MICHAEL R , SUMMERS JAMES B
IPC: A61K31/55 , A61K38/05 , C07D225/06 , C07D245/02 , C07D245/06 , C07D255/02 , C07D267/00 , C07D413/04 , C07D413/06 , C07D417/06 , C07D487/08 , C07K5/078
Abstract: Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：ZA9800020B
公开(公告)日：1998-07-02
申请号：ZA9800020
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , HOLMS JAMES H , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , XU LIANHONG , GUO YAN , SUMMERS JAMES B
IPC: A61K31/395 , A61K31/40 , A61K31/404 , A61K31/4188 , A61K31/427 , A61K31/4427 , A61K31/4523 , A61K31/553 , A61K38/00 , A61K38/55 , A61P1/02 , A61P7/00 , A61P11/06 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D273/01 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D487/08 , C07K5/078 , C07D , A61K
CPC classification number: C07D413/04 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D413/06 , C07D417/06 , C07D487/08 , C07K5/06139
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公开(公告)号：ZA9800018B
公开(公告)日：1998-07-02
申请号：ZA9800018
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , XU LIANHONG , CURTIN MICHAEL L , WADA CAROL K , FLORJANCIC ALAN SCOTT , GIESLER JAMIE R , GUO YAN , MICHAELIDES MICHAEL R , HOLMS JAMES H
IPC: A61K31/165 , A61K31/197 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/32 , C07C259/06 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/22 , C07F , A61K , C07C
CPC classification number: C07D207/335 , C07B2200/07 , C07C233/32 , C07C259/06 , C07C2601/14 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/28 , C07D333/22
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公开(公告)号：AU690620B2
公开(公告)日：1998-04-30
申请号：AU1303695
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B JR , DAVIDSEN STEVEN K , CURTIN MICHAEL L , HEYMAN H ROBIN , SHEPPARD GEORGE S , XU LIANHONG , CARRERA GEORGE M JR , GARLAND ROBERT B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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Patent Agency Ranking
公开(公告)号：DE69809924T2
公开(公告)日：2003-08-21
申请号：DE69809924
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：DE69429827T2
公开(公告)日：2002-11-21
申请号：DE69429827
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS B , DAVIDSEN K , CURTIN L , HEYMAN ROBIN , SHEPPARD S , XU LIANHONG , CARRERA M , GARLAND B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：AT212992T
公开(公告)日：2002-02-15
申请号：AT95904287
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B JR , DAVIDSEN STEVEN K , CURTIN MICHAEL L , HEYMAN H ROBIN , SHEPPARD GEORGE S , XU LIANHONG , CARRERA GEORGE M JR , GARLAND ROBERT B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：HU0002037A2
公开(公告)日：2001-05-28
申请号：HU0002037
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：CZ473099A3
公开(公告)日：2000-06-14
申请号：CZ473099
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN ROBIN H , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: A61K31/16 , A61P19/02 , A61P35/00 , C07C259/00 , C07C259/04
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