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公开(公告)号:DE4425144A1
公开(公告)日:1996-01-18
申请号:DE4425144
申请日:1994-07-15
Applicant: BASF AG
Inventor: HELLENDAHL BEATE DR , LANSKY ANNEGRET DR , MUNSCHAUER RAINER DR , BIALOJAN SIEGFRIED DR , UNGER LILIANE DR , TESCHENDORF HANS-JUERGEN DR ME , WICKE CARSTEN DR , DRESCHER KARLA DR
IPC: C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/505 , A61K31/53 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D249/12 , C07D249/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: The present invention relates to triazole compounds of formula (I) in which R , R stand for H or different substituents, A stands for a bivalent group, B stands for a rest of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.
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公开(公告)号:DE4341403A1
公开(公告)日:1995-06-08
申请号:DE4341403
申请日:1993-12-04
Applicant: BASF AG
Inventor: STEINER GERD DR , MUNSCHAUER RAINER DR , UNGER LILIANE DR , TESCHENDORF HANS-JUERGEN DR ME , HOEGER THOMAS DR
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61P21/02 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/14 , C07D209/18 , C07D209/44 , C07D209/52 , C07D487/04 , C07D491/048 , C07D497/04 , C07D487/08 , C07D417/12 , C07D498/18 , C07D471/18 , A61K31/46
Abstract: PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.
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公开(公告)号:DE4119757A1
公开(公告)日:1992-12-17
申请号:DE4119757
申请日:1991-06-15
Applicant: BASF AG
IPC: A61K31/425 , A61K31/426 , A61K31/435 , A61K31/495 , A61P9/12 , C07D277/20 , C07D277/34 , C07D417/06 , C07D417/12
Abstract: Described are aminoalkyl-substituted thiazolin-2-ones derivatives of the formula (I), in which n and A are as defined in the description, as well as their preparation. The compounds are suitable for use in the treatment of illnesses.
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公开(公告)号:DE3923675A1
公开(公告)日:1991-01-24
申请号:DE3923675
申请日:1989-07-18
Applicant: BASF AG
IPC: C07D277/20 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/505 , A61P25/00 , A61P43/00 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/46 , C07D417/00 , C07D417/06 , C07D417/12 , C07D417/14
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公开(公告)号:DE3834860A1
公开(公告)日:1990-04-19
申请号:DE3834860
申请日:1988-10-13
Applicant: BASF AG
Inventor: FRICKEL FRITZ-FRIEDER DR , KUEKENHOEHNER THOMAS DR , RENDENBACH BEATRICE DR , WEIFENBACH HARALD DR , TESCHENDORF HANS-JUERGEN DR ME
IPC: A61K31/335 , A61K31/35 , A61K31/40 , A61K31/41 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61P25/00 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12
Abstract: Heterocyclically substituted alkoxycoumarins of the formula in which R and R are, independently of one another, hydrogen, C1- to C5-alkyl, trifluoromethyl, phenyl, halogen or together are a C3- to C5-alkylene chain; furthermore R is C1- to C5-alkyl or halogen; n is an integer from 0 to 3; R is hydrogen or C1- to C4-alkyl and Het is one of the following heterocycles: with the following meanings for the symbols used: X is oxygen or sulphur; R is optionally C1-C4-alkoxy-substituted C1-C10-alkyl, 5-6-membered oxacycloalkyl, C3-C7-cycloalkyl, benzyl, an optionally halogen- or NO2-substituted phenyl radical, a pyridine ring, C1-C5-alkoxycarbonyl, perfluoro-C1-C2-alkyl; R is C1-C5-alkyl, C1-C5-alkoxy; R is C1-C5-alkyl, an optionally halogen-substituted benzyl radical, halogen; m is 0 to 2; R is C1-C5-alkyl, C3-C6-cycloalkyl, benzyl, phenyl; R is hydrogen, C1-C4-alkyl; R is C1-C5-alkyl, C3-C6-cycloalkyl; R is C1-C5-alkyl; R is hydrogen, C1-C5-alkyl, C3-C6-cycloalkyl; R is C1-C5-alkyl, halogen, p = 0 to 2; R is C1-C5-alkyl, q = 0 or 1; R , R are hydrogen, C1-C5-alkyl, benzyl; R is hydrogen, C1-C5-alkyl; R is C1-C5-alkyl with the proviso that R is not phenyl when X is oxygen, R is methyl and R to R are hydrogen, method for their preparation and medicaments prepared therefrom.
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公开(公告)号:DE3542197A1
公开(公告)日:1987-06-04
申请号:DE3542197
申请日:1985-11-29
Applicant: BASF AG
Inventor: MAY HANS-JOACHIM DR , TRAUT MARTIN DR , WEIFENBACH HARALD DR , BALDINGER VERENA DR , GRIES JOSEF DR MED , TESCHENDORF HANS-JUERGEN DR ME
IPC: A61K31/50 , A61P25/00 , A61P25/24 , A61P25/26 , C07D237/20
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公开(公告)号:DE3524744A1
公开(公告)日:1987-01-15
申请号:DE3524744
申请日:1985-07-11
Applicant: BASF AG
Inventor: STEINER GERD DR , TESCHENDORF HANS-JUERGEN DR ME , UNGER LILIANE DR
IPC: A61K31/55 , A61P25/00 , A61P25/08 , A61P25/20 , C07D495/04 , C07D495/06
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公开(公告)号:DE3243158A1
公开(公告)日:1984-05-24
申请号:DE3243158
申请日:1982-11-23
Applicant: BASF AG
Inventor: SCHLECKER RAINER DR , SCHMIDT PETER DR , THIEME PETER C DR , LENKE DIETER PROF DR , TESCHENDORF HANS-JUERGEN DR ME , TRAUT MARTIN DR , MUELLER CLAUS D DR MED , HOFMANN HANS PETER DR , KREISKOTT HORST PROF DR
IPC: A61K31/35 , A61K31/352 , A61K31/365 , A61K31/37 , A61P25/18 , A61P25/24 , A61P25/26 , A61P37/08 , A61P43/00 , C07D311/08 , C07D311/16 , C07D311/78 , C07D311/80
Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.
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