公开(公告)号：NZ760006A

公开(公告)日：2022-07-29

申请号：NZ76000614

申请日：2014-12-12

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  ANDERSON COREY ,  LITTLER BENJAMIN JOSEPH ,  GOLEC JULIAN MARIAN ,  ZHANG BEILI ,  KESHAVARZ-SHOKRI ALI ,  ALCACIO TIM ,  BELMONT DANIEL

IPC: C07F9/576 ,  A61K31/675 ,  A61P19/02

Abstract: The invention relates to compounds of formula I which are prodrug pyridone amides useful as modulators of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

公开(公告)号：NZ720444A

公开(公告)日：2022-07-29

申请号：NZ72044414

申请日：2014-12-12

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  ANDERSON COREY ,  LITTLER BENJAMIN JOSEPH ,  GOLEC JULIAN MARIAN ,  ZHANG BEILI ,  KESHAVARZ-SHOKRI ALI ,  ALCACIO TIM ,  BELMONT DANIEL

IPC: A61K31/675 ,  C07F9/576 ,  A61P19/02

Abstract: The invention relates to prodrug inhibitors of Nav 1.8 channels which possess phosphonate substituted pyridone moieties. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The prodrugs of the invention possess advantageous solubility and physicochemical properties.

公开(公告)号：EA039280B1

公开(公告)日：2021-12-28

申请号：EA201991403

申请日：2017-12-08

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  ALCACIO TIMOTHY ,  ANDERSON COREY ,  ANGELL PAUL TIMOTHY ,  BAEK MINSON ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  FERRIS LORI ANN ,  GROOTENHUIS PETER DIEDERIK JAN ,  GROSS RAYMOND STANLEY ,  GULEVICH ANTON ,  HADIDA RUAH SARA SABINA ,  HSIA CLARA KUANG-JU ,  HUGHES ROBERT M ,  JOSHI PRAMOD VIRUPAX ,  KANG PING ,  KESHAVARZ-SHOKRI ALI ,  KHATUYA HARIPADA ,  KRENITSKY PAUL JOHN ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE JEAN DENIS ,  SHI YI ,  SHRESTHA MUNA ,  SIESEL DAVID ANDREW ,  STAVROPOULOS KATHY ,  TERMIN ANDREAS P ,  UY JOHNNY ,  VAN GOOR FREDRICK F ,  YOUNG TIMOTHY JOHN ,  ZHOU JINGLAN

Abstract: Визобретенииописанымодуляторрегуляторатрансмембраннойпроводимостипримуковисцидозе (CFTR) формулы 1, атакжеегодейтерированноепроизводное, фармацевтическиекомпозиции, содержащиеуказанныймодулятор, испособылечениямуковисцидоза.

公开(公告)号：BR112012024338B1

公开(公告)日：2021-09-28

申请号：BR112012024338

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEIL ,  ELAINE CHUNGMIN LEE ,  KRAWIEC MARIUSZ ,  TIM EDWARD ALCACIO ,  ZHANG YUEGANG

IPC: C07D405/12 ,  A61K31/404 ,  A61P11/00

Abstract: formas sólidas de (r)-1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il) ciclopropanocarboxamida, composições farmacêuticas e dispersões sólidas compreendendo as mesmas, processo de preparação e usos das mesmas, e kit compreendendo as mesmas. a presente invenção se refere às formas sólidas de (r)-1-(2,2-diflúorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropanocarboxamida (composto 1) na forma substancialmente cristalina (forma a) ou forma amorfa, composições farmacêuticas das mesmas e usos das mesmas.

公开(公告)号：HUE052205T2

公开(公告)日：2021-04-28

申请号：HUE17826629

申请日：2017-12-08

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER ,  ALCACIO TIMOTHY ,  ANDERSON COREY ,  ANGELL PAUL ,  BAEK MINSON ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  FERRIS LORI ,  GROOTENHUIS PETER DIEDERIK ,  GROSS RAYMOND ,  GULEVICH ANTON ,  HADIDA RUAH SARA ,  HSIA CLARA ,  HUGHES ROBERT ,  JOSHI PRAMOD ,  KANG PING ,  KESHAVARZ-SHOKRI ALI ,  KHATUYA HARIPADA ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MILLER MARK ,  PARASELLI PRASUNA ,  PIERRE FABRICE JEAN ,  SHI YI ,  SHRESTHA MUNA ,  SIESEL DAVID ,  STAVROPOULOS KATHY ,  TERMIN ANDREAS ,  UY JOHNNY ,  VAN GOOR FREDRICK ,  YOUNG TOMOTHY ,  ZHOU JINGLAN

IPC: A61P11/00

公开(公告)号：AU2019271928B2

公开(公告)日：2021-04-22

申请号：AU2019271928

申请日：2019-11-26

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY ,  HADIDA-RUAH SARA SABINA ,  GOLEC JULIAN MARIAN CHARLES ,  ZHANG BEILI ,  LITTLER BENJAMIN JOSEPH ,  KESHAVARZ-SHOKRI ALI ,  ALCACIO TIM EDWARD ,  BELMONT DANIEL T

IPC: C07F9/576 ,  A61K31/675 ,  A61P19/02

Abstract: The invention relates to prodrug compounds of formula I: O -NO-X Ry wherein R2 , R 3, R, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

公开(公告)号：ES2804202T3

公开(公告)日：2021-02-04

申请号：ES17154840

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ ,  NUGENT WILLIAM A

IPC: C07D405/12

Abstract: Un compuesto de la fórmula: **(Ver fórmula)** o una sal del mismo.

公开(公告)号：DK2826776T3

公开(公告)日：2020-12-14

申请号：DK14172991

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ ,  ALCACIO TIM EDWARD

IPC: A61K9/10 ,  A61K31/404 ,  A61P11/00 ,  C07D405/12

公开(公告)号：PL3170818T3

公开(公告)日：2020-09-21

申请号：PL16198922

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/4709 ,  A61P11/00

公开(公告)号：UA121379C2

公开(公告)日：2020-05-25

申请号：UAA201607639

申请日：2014-12-12

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY ,  HADIDA-RUAH SARA SABINA ,  GOLEC JULIAN MARIAN CHARLES ,  ZHANG BEILI ,  LITTLER BANJAMIN JOSEPH ,  KESHAVARZ-SHOKRI ALI ,  ALCACIO TIM EDWARD ,  BELMONT DANIEL T

Abstract: ВинахідстосуєтьсяпролікарськихсполукформулиІ: , Іде R2, R3, R5, R7 і X маютьзначення, визначенів даномудокументі. Данийвинахідтакожнадаєфармацевтичноприйнятнікомпозиції, якімістятьсполукизаданимвинаходом, іспособизастосуваннякомпозиційу лікуваннірізнихрозладів, включаючибіль. СполукиформулиІ маютькращірозчинністьі фізико-хімічнівластивості.