公开(公告)号：AU2009313198B2

公开(公告)日：2016-03-24

申请号：AU2009313198

申请日：2009-11-10

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA ,  YOUNG STEPHEN ,  BINCH HAYLEY ,  CLEVELAND THOMAS ,  FANNING LEV T D ,  HURLEY DENNIS ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA ,  REAPER PHILIP MICHAEL

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R

公开(公告)号：ZA201201977B

公开(公告)日：2013-05-29

申请号：ZA201201977

申请日：2012-03-16

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  O'DONNELL MICHAEL

IPC: C07D20060101

Abstract: A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims. Additionally, the present invention relates to compounds of Structural Formula (I), which are useful as inhibitors of protein kinase.

公开(公告)号：SG179206A1

公开(公告)日：2012-04-27

申请号：SG2012019022

申请日：2010-09-24

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  O'DONNELL MICHAEL

Abstract: A method of preparing a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the steps of: a) reacting a compound represented by Structural Formula (A) with FTNR1R7 under suitable conditions to form a compound represented by Structural Formula (B); and b) i) when R12 is -NO2, and R11 is -OR14: 1) cyclizing the compound represented by Structural Formula (B) under suitable cyclisation conditions to form a compound represented by Structural Formula (II); and 2) optionally reacting the compound represented by Structural Formula (II) with R9-LG2, wherein LG2 is a suitable leaving group, to form the compound represented by Structural Formula (I), wherein R8 is R9; or ii) when R12 is halogen, and R11 is -NHR13: 1) cyclizing the compound represented by Structural Formula (B) under suitable cyclisation conditions to form the compound represented by Structural Formula (I); and 2) optionally, when R13 is - H, reacting the compound produced from step b), ii), 1) with R9-LG2, wherein LG2 is a suitable leaving group, to form the compound represented by Structural Formula (I) wherein R8 is R9.

公开(公告)号：SG172248A1

公开(公告)日：2011-07-28

申请号：SG2011044724

申请日：2009-12-18

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I):wherein the variables are as defined herein.

公开(公告)号：MX2009006700A

公开(公告)日：2009-06-30

申请号：MX2009006700

申请日：2007-12-21

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL ,  KNEGTEL RONALD ,  BRENCHLEY GUY ,  DURRANT STEVEN ,  CHARRIER JEAN DAMIEN ,  YOUNG STEPHEN CLINTON ,  EVERITT SIMON ROBERT LORRIE ,  PINDER JOANNE LOUISE ,  RUTHERFORD ALISTAIR PETER ,  O'DONNELL MICHAEL

IPC: A61K31/506 ,  A61K31/551 ,  A61P3/00 ,  A61P5/00 ,  A61P9/00 ,  A61P11/06 ,  A61P19/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00

Abstract: La presente invención se refiere a compuestos útiles como inhibidores de proteína-cinasas. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden estos compuestos y métodos para usar las composiciones en el tratamiento de varias enfermedades, condiciones o trastornos. La invención también proporciona procesos para preparar compuestos de la invención.

公开(公告)号：NO20082508A

公开(公告)日：2008-07-31

申请号：NO20082508

申请日：2008-05-30

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL PAUL ,  STUDLEY JOHN ,  BOYALL DEAN ,  FRAYSSE DAMIEN ,  ROBINSON DANIEL ,  BINCH HAYLEY ,  EVERITT SIMON ,  DAVIS CHRIS ,  RAMAYA SHARN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAR ,  PINDER JOANNE

IPC: C07D403/12 ,  A61K31/506 ,  A61P35/00 ,  C07D403/14 ,  C07D417/12

CPC classification number: C07D403/12 ,  C07D239/38 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

公开(公告)号：DE602004014117D1

公开(公告)日：2008-07-10

申请号：DE602004014117

申请日：2004-03-25

Applicant: VERTEX PHARMA

Inventor： BRENCHLEY GUY ,  FARMER LUC J ,  HARRINGTON EDMUND MARTIN ,  KNEGTEL RONALD ,  O'DONNELL MICHAEL ,  SAOEITURO FRANCESCO G ,  STUDLEY JOHN R ,  WANG JIAN

IPC: A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D417/00 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AT396731T

公开(公告)日：2008-06-15

申请号：AT04758338

申请日：2004-03-25

Applicant: VERTEX PHARMA

Inventor： BRENCHLEY GUY ,  FARMER LUC J ,  HARRINGTON EDMUND MARTIN ,  KNEGTEL RONALD ,  O'DONNELL MICHAEL ,  SAOEITURO FRANCESCO G ,  STUDLEY JOHN ,  WANG JIAN

IPC: A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D417/00 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CA2627857A1

公开(公告)日：2007-05-18

申请号：CA2627857

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： RUTHERFORD ALISTAIR ,  STUDLEY JOHN ,  PINDER JOANNE ,  BINCH HAYLEY ,  MILLER ANDREW ,  MORTIMORE MICHAEL ,  FRAYSSE DAMIEN ,  RAMAYA SHARN ,  ROBINSON DANIEL ,  EVERITT SIMON ,  DAVIS CHRIS ,  BOYALL DEAN ,  O'DONNELL MICHAEL

IPC: A61K31/505 ,  C07D239/02

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

公开(公告)号：AU2006311797A1

公开(公告)日：2007-05-18

申请号：AU2006311797

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： ROBINSON DANIEL ,  O'DONNELL MICHAEL ,  STUDLEY JOHN ,  DAVIS CHRIS ,  RUTHERFORD ALISTAIR ,  MORTIMORE MICHAEL ,  BINCH HAYLEY ,  PINDER JOANNE ,  EVERITT SIMON ,  RAMAYA SHARN ,  MILIER ANDREW ,  FRAYSSE DAMIEN ,  BOYALL DEAN

IPC: A61K31/505 ,  C07D239/02

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.