公开(公告)号：HRP20151137T1

公开(公告)日：2015-11-20

申请号：HRP20151137

申请日：2015-10-27

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：BRPI1011506A2

公开(公告)日：2015-08-25

申请号：BRPI1011506

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  GOOR FREDERICK F VAN ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：NZ595153A

公开(公告)日：2014-05-30

申请号：NZ59515310

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: C07D215/233 ,  A61K31/365 ,  C07D215/56 ,  C07D307/83

Abstract: The disclosure provides a process for the preparation of a substituted 4-Hydroxy-N-phenylquinoline-3-carboxamide derivative of Formula 1; comprising coupling a substituted 4-Hydroxyquinoline-3-carboxylic acid derivative of Formula 2; with an substituted aniline of Formula 3; in the presence of a coupling agent. The compounds of formula I being useful as cystic fibrosis transmembrane conductance regulators.

公开(公告)号：AU2008301907B2

公开(公告)日：2014-02-20

申请号：AU2008301907

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： ZHANG YUEGANG ,  LOOKER ADAM ,  DEMATTEI JOHN ,  ROEPER STEFANIE ,  HARRISON CRISTIAN ,  FENG YUSHI ,  MUDUNURI PRAVEEN

IPC: C07D215/233

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

公开(公告)号：NZ600865A

公开(公告)日：2014-01-31

申请号：NZ60086508

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： FENG YUSHI ,  LOOKER ADAM ,  ZHANG YUEGANG ,  DEMATTEI JOHN ,  MUDUNURI PRAVEEN ,  ROEPER STEFANIE ,  HARRISON CRISTIAN

IPC: A61K31/47 ,  A61P3/00 ,  A61P3/10 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  C07D215/233

Abstract: 600865 Disclosed is N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1)• PEG 400 (polyethylene glycol)•KOAc (potassium acetate). Also disclosed are crystalline form and x-ray powder diffraction patterns of Compound 1•PEG 400•KOAc, pharmaceutical combinations comprising Compound 1•PEG 400•KOAc, methods of making Compound 1•PEG 400•KOAc and the use of Compound 1•PEG 400•KOAc in the manufacture of a medicament. The medicament is useful in the treatment of cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation- fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjogren’s disease.

公开(公告)号：MX2011008499A

公开(公告)日：2011-09-06

申请号：MX2011008499

申请日：2010-02-12

Applicant: VERTEX PHARMA

Inventor： SNOONIAN JOHN R ,  VLAHOVA PETINKA ,  EDDLESTON MARK ,  HURREY MICHAEL ,  ALARGOV DIMITAR ,  JOHNSTON STEVEN C ,  ROEPER STEFANIE ,  COWANS BRETT A ,  EBERLIN ALEXANDERS ,  FRAMPTON CHRISTOPHER

IPC: C07D213/82 ,  A61K31/4418

Abstract: Esta invención se refiere a formas sólidas de 2-(2,4-difluorofenil)-6-(1-(2,6-difluorofenil)ureido)nicotinamida y composiciones farmacéuticas de la misma, y métodos y usos con las mismas.

公开(公告)号：CA2984994A1

公开(公告)日：2010-09-23

申请号：CA2984994

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/56

Abstract: The invention provides a process for the preparation of a compound of Formula 1; (See Formula 1) comprising coupling a carboxylic acid of Formula 2; (See Formula 2) with an aniline of Formula 3; (See Formula 3) in the presence of a coupling agent.

公开(公告)号：ES3003533T3

公开(公告)日：2025-03-10

申请号：ES18816468

申请日：2018-11-30

Applicant: VERTEX PHARMA

Inventor： LEMERCIER LEWANDOWSKI BERENICE ,  LEWIS ROBERT ,  LOOKER ADAM ,  MORGAN ADAM ,  ROEPER STEFANIE ,  RYAN MICHAEL ,  SOLSONA ROCABERT JUAN ,  WILDE NATHAN

IPC: C07D215/56 ,  C07B59/00 ,  C07C33/18 ,  C07C69/96

Abstract: La divulgación proporciona procesos para sintetizar compuestos para su uso como moduladores de CFTR. (Traducción automática con Google Translate, sin valor legal)

公开(公告)号：JOP20210301A1

公开(公告)日：2023-01-30

申请号：JOP20210301

申请日：2020-05-14

Applicant: VERTEX PHARMA

Inventor： SHI YI ,  TAPLEY TIMOTHY LEWIS ,  SWETT REBECCA JANE ,  XU JINWANG ,  MAXWELL JOHN PATRICK ,  SHRESTHA MUNA ,  OVERHOFF KIRK ALAN ,  BANDARAGE UPUL KEERTHI ,  BRODNEY MICHAEL AARON ,  BLIGH CAVAN MCKEON ,  BOUCHER DIANE ,  BOYD MICHAEL JOHN ,  TANG QING ,  THOMSON STEPHEN ,  GAGNON KEVIN JAMES ,  GREY JR RONALD LEE ,  JONES PETER ,  JOHNSON JR MAC ARTHUR ,  GUIDO SAMANTHA ,  GIACOMETTI ROBERT DANIEL ,  GIROUX SIMON ,  DAMAGNEZ VERONIQUE ,  RODAY SETU ,  RONKIN STEVEN M ,  ROEPER STEFANIE ,  ZAKY MARIAM ,  SAWANT RUPA ,  SPOSATO MARISA ,  STAVROPOULOS KATHY ,  GARCIA BARRANTES PEDRO MANUEL ,  FANNING LEV TYLER DEWEY ,  FLEMING GABRIELLE SIMONE ,  FIMOGNARI ROBERT FRANCIS ,  CLARK MICHAEL PHILIP ,  COTTRELL KEVIN MICHAEL ,  KESAVAN SARATHY ,  LAI MEI-HSIU ,  LOOKER ADAM ,  LIU SIYING ,  MAXWELL BRAD ,  MEDEK ALES ,  NUHANT PHILIPPE MARCEL ,  HOOD SARAH CAROL ,  HALL AMY BETH ,  HURLEY DENNIS JAMES

Abstract: يوفرالكشفالحاليمركباتمُفيدةلعلاجنقصمضادتريبسينألفا-1 (AATD)،وفقًاللصيغة (I): (I)،ومماثلاتكيميائيةمنها،وأملاحمقبولةصيدليًامنالمركبات،وأملاحمقبولةصيدليًامنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالمركبات،ومشتقاتمعالجةبالديوتريوممنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالأملاح،والصورالصلبةمنتلكالمركباتوعملياتتحضيرتلكالمركبات.

公开(公告)号：MA55971A

公开(公告)日：2022-03-23

申请号：MA55971

申请日：2020-05-14

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL KEERTHI ,  BLIGH CAVAN MCKEON ,  BOUCHER DIANE ,  BOYD MICHAEL JOHN ,  BRODNEY MICHAEL AARON ,  CLARK MICHAEL PHILIP ,  COTTRELL KEVIN MICHAEL ,  DAMAGNEZ VERONIQUE ,  FANNING LEV TYLER DEWEY ,  FIMOGNARI ROBERT FRANCIS ,  FLEMING GABRIELLE SIMONE ,  GAGNON KEVIN JAMES ,  GARCIA BARRANTES PEDRO MANUEL ,  GIACOMETTI ROBERT DANIEL ,  GIROUX SIMON ,  GREY JR RONALD LEE ,  GUIDO SAMANTHA ,  HALL AMY BETH ,  HOOD SARAH CAROL ,  HURLEY DENNIS JAMES ,  JOHNSON JR MAC ARTHUR ,  JONES PETER ,  KESAVAN SARATHY ,  LAI MEI-HSIU ,  LIU SIYING ,  LOOKER ADAM ,  MAXWELL BRAD ,  MAXWELL JOHN PATRICK ,  MEDEK ALES ,  NUHANT PHILIPPE MARCEL ,  OVERHOFF KIRK ALAN ,  RODAY SETU ,  ROEPER STEFANIE ,  RONKIN STEVEN M ,  SAWANT RUPA ,  SHI YI ,  SHRESTHA MUNA ,  SPOSATO MARISA ,  STAVROPOULOS KATHY ,  SWETT REBECCA JANE ,  TANG QING ,  TAPLEY TIMOTHY LEWIS ,  THOMSON STEPHEN ,  XU JINWANG ,  ZAKY MARIAM

IPC: A61K31/4162 ,  A61K31/429 ,  A61P1/16 ,  A61P11/00 ,  C07D231/56 ,  C07D487/04 ,  C07D498/18 ,  C07D513/04