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41.发明专利
公开(公告)号：JOP20190125A1
公开(公告)日：2017-06-16
申请号：JOP20190125
申请日：2019-05-28
Applicant: VERTEX PHARMA
Inventor： ZHOU JINGLAN , VAN GOOR FREDRICK F , HADIDA RUAH SARA SABINA , SIESEL DAVID ANDREW , CLEVELAND THOMAS , GULEVICH ANTON , PIERRE FABRICE JEAN DENIS , STAVROPOULOS KATHY , GROOTENHUIS PETER DIEDERIK JAN , KANG PING , YOUNG TOMOTHY JOHN , ANDERSON COREY , ALCACIO TIMOTHY , KESHAVARZ-SHOKRI ALI , MCCARTNEY JASON , ANGELL PAUL TIMOTHY , GROSS RAYMOND STANLEY , MILLER MARK THOMAS , HUGHES ROBERT M , ABELA ALEXANDER RUSSELL , JOSHI PRAMOD VIRUPAX , SHI YI , CLEMENS JEREMY J , UY JOHNNY , BAEK MINSON , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , TERMIN ANDREAS P , SHRESTHA MUNA , FERRIS LORI ANN , HSIA CLARA KUANG-JU , PARASELLI PRASUNA
Abstract: يتمالكشفعنمركباتلهاالصيغة ( I )، أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،وطرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها. كمايتمالكشفعنصورفيالحالةالصلبةللمركب 1 وأملاحوذواباتمنه.
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公开(公告)号：MX388103B
公开(公告)日：2025-03-19
申请号：MX2019006637
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , KESHAVARZ-SHOKRI ALI , TERMIN ANDREAS P , GULEVICH ANTON , HSIA CLARA KUANG-JU , ANDERSON COREY , SIESEL DAVID ANDREW , PIERRE FABRICE JEAN DENIS , VAN GOOR FREDRICK F , KHATUYA HARIPADA , MCCARTNEY JASON , CLEMENS JEREMY J , ZHOU JINGLAN , UY JOHNNY , STAVROPOULOS KATHY , FERRIS LORI ANN , MILLER MARK THOMAS , BAEK MINSON , SHRESTHA MUNA , KRENITSKY PAUL JHON , ANGELL PAUL TIMOTHY , GROOTENHUIS PETER DIEDIERIK JAN , KANG PING , JOSHI PRAMOD VIRUPAX , PARASELLI PRASUNA , GROSS RAYMOND STANLEY , HUGHES ROBERT M , HADIDA RUAH SARA SABINA , CLEVELAND THOMAS , ALCACIO TIMOTHY , YOUNG TOMOTHY JOHN , SHI YI
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Se describen compuestos de Fórmula (I): (ver fórmulas) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los anteriores y metabolitos de cualquiera de los anteriores. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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公开(公告)号：HRP20211683T1
公开(公告)日：2022-03-04
申请号：HRP20211683
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：MD3519401T2
公开(公告)日：2022-02-28
申请号：MDE20190875
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compuşii cu Formula I:sărurile acceptabile farmaceutic ale acestora, derivaţii deuteraţi ai oricărora dintre cei anteriori, şi metaboliţii oricărora dintre cei anteriori sunt divulgaţi. Compoziţiile farmaceutice care-i cuprind pe aceştia, metodele de tratare a fibrozei chistice utilizȃndu-i pe aceştia, şi metodele pentru fabricarea acestora sunt de asemenea divulgate.
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公开(公告)号：SI3519401T1
公开(公告)日：2022-01-31
申请号：SI201731014
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D471/00 , C07D498/00
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Patent Agency Ranking
公开(公告)号：PL3519401T3
公开(公告)日：2022-01-31
申请号：PL17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：DK3519401T3
公开(公告)日：2021-11-22
申请号：DK17792230
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
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公开(公告)号：PL3203840T3
公开(公告)日：2021-01-11
申请号：PL15849396
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：RS60906B1
公开(公告)日：2020-11-30
申请号：RSP20201210
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：DK3551622T3
公开(公告)日：2020-11-23
申请号：DK17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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