公开(公告)号：SI1147101T1

公开(公告)日：2003-06-30

申请号：SI200030041

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/335 ,  A61P35/04 ,  C07D207/09 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28

公开(公告)号：DK1147101T3

公开(公告)日：2003-03-10

申请号：DK00905758

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NZ512372A

公开(公告)日：2003-01-31

申请号：NZ51237200

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28

Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting pharmaceutical compositions and uses of the compounds of formula (I) in inhibiting matrix metalloproteinase in a mammal. In formula (I): W1 is -O-, -CH20- or -CH2- wherein each group is drawn with its left-hand end being the end which attaches to the carbon containing R1 and R2, and its right-hand end being the end which attaches to the carbon containing R3 and R4. X is -O- or -N (R7)-, wherein R7 is hydrogen, alkyl, -SO2-alkyl, or alkanoyl. R1 and R2 are independently selected hydrogen, alkyl or hydroxyalkyl. R3 and R4 are independently selected hydrogen or alkyl or R3 and R4 taken together are oxo, or R3 and R4, taken together with the carbon atom to which they are attached, form a cycloalkyl ring. R5 and R6 are independently selected from hydrogen, alkyl, perfluoroalkyl, halo, haloalkyl, alkoxy, hydroxy, hydroxyalkyl, alkoxyalkyl or nitro. Y1 is a covalent bond, -O-, alkylene of two to four carbon atoms, piperidineneyl, alkenylene of two carbon atoms, alkynylene of two carbon atoms, SO2- or -C(O)-. Ar is phenyl, pyridyl, pyrazinyl, pyridazinyl, furyl, thienyl, isoxazolyl, oxazolyl, thiazolyl or isothiazolyl, which can be optionally substituted with one, two, or three substituents.

公开(公告)号：PL349771A1

公开(公告)日：2002-09-09

申请号：PL34977100

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NO20013669L

公开(公告)日：2001-09-27

申请号：NO20013669

申请日：2001-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NO20013669D0

公开(公告)日：2001-07-26

申请号：NO20013669

申请日：2001-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  C07D

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：AU2739100A

公开(公告)日：2000-08-18

申请号：AU2739100

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NZ592802A

公开(公告)日：2013-07-26

申请号：NZ59280209

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H

IPC: A61P35/00 ,  A61K31/496 ,  C07D403/12

Abstract: 592802 Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. Compounds of the present disclosure include: 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-l-en-l-yl]methyl} piperazin-l-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide, N-({ 5-chloro-6-[(4,4-difluorocyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide, 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-5 yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)-2-[2-(1H-pyrazol-4-yl)phenoxy]benzamide, Trans-2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-cyanocyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide, 2-[(2-amino-5-bromopyridin-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide, N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide, tert-butyl 4-(5-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-{ [({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)amino]carbonyl} phenoxy)pyridin-2-ylcarbamate and 2-(4-(acetylamino)phenoxy)-4-(4-((4'-chloro-1,1'-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide.

公开(公告)号：ES2398074T3

公开(公告)日：2013-03-13

申请号：ES10164213

申请日：2004-05-21

Applicant: ABBOTT LAB

Inventor： DAI YUJIA ,  DAVIDSEN STEVEN ,  ERICSSON ANNA ,  HARTANDI KRESNA ,  JI ZHIQIN ,  MICHAELIDES MICHAEL

IPC: C07D231/56 ,  A61K31/416 ,  A61K31/42 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4709 ,  A61P35/00 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D413/02

Abstract: El compuesto de fórmula (II) o una sal terapéuticamente aceptable del mismo, en la que X se selecciona entre el grupo que consiste en O y S; R1 y R2 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alcoxi, alcoxialcoxi,alcoxialquilo, alquilo, ariloxi, ariloxialquilo, halo, haloalcoxi, haloalquilo, heterociclilo, heterociclilalquenilo,heterociclilalcoxi, heterociclilalquilo, heterocicliloxialquilo, hidroxi, hidroxialcoxi, hidroxialquilo, (NRaRb)alcoxi,(NRaRb)alquenilo, (NRaRb)alquilo, (NRaRb)carbonilalquenilo y (NRaRb)carbonilalquilo;R3 y R4 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alcoxi, alquilo, halo,haloalcoxi, haloalquilo e hidroxi; L se selecciona entre el grupo que consiste en (CH2)mN(R7)C(O)N(R8)(CH2)n y CH2C(O)NR7, en la que m y nson independientemente 0 ó 1, y en la que cada grupo se dibuja con su extremo izquierdo unido al anillosustituido con R3 y R4.

公开(公告)号：SG181506A1

公开(公告)日：2012-07-30

申请号：SG2012041018

申请日：2010-06-01

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.