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公开(公告)号：DE69809924D1
公开(公告)日：2003-01-16
申请号：DE69809924
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AU4340202A
公开(公告)日：2002-06-18
申请号：AU4340202
申请日：2001-10-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K
IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10
Abstract: Substituted trifluoromethyl ketones, ketooxazoles, ketoamides, ketoesters, and diketones having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
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公开(公告)号：TR199903287T2
公开(公告)日：2000-09-21
申请号：TR9903287
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：BG103995A
公开(公告)日：2000-07-31
申请号：BG10399599
申请日：1999-12-13
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
Abstract: The compounds with the formula are inhibitors of matrix metallproteinases. The invention also relates to pharmaceutical compositions and methods for the inhibition of matrix metallproteinases in mammals. 18 claims
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公开(公告)号：NO996579L
公开(公告)日：2000-01-24
申请号：NO996579
申请日：1999-12-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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Patent Agency Ranking
公开(公告)号：NO996579A
公开(公告)日：2000-01-24
申请号：NO996579
申请日：1999-12-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：DK0595924T3
公开(公告)日：1999-11-01
申请号：DK92915895
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：AT178796T
公开(公告)日：1999-04-15
申请号：AT92915895
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：ZA9806828B
公开(公告)日：1999-01-29
申请号：ZA9806828
申请日：1998-07-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE R , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C , A61K , C07D
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：ZA9820B
公开(公告)日：1998-07-02
申请号：ZA9820
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , HOLMS JAMES H , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , XU LIANHONG , GUO YAN , SUMMERS JAMES B
IPC: A61K31/395 , A61K31/40 , A61K31/404 , A61K31/4188 , A61K31/427 , A61K31/4427 , A61K31/4523 , A61K31/553 , A61K38/00 , A61K38/55 , A61P1/02 , A61P7/00 , A61P11/06 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D273/01 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D487/08 , C07K5/078 , C07D , A61K
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