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    Novel tetrapeptides as antitumor agents
    51.
    发明专利
    Novel tetrapeptides as antitumor agents 未知

    公开(公告)号：ZA976723B

    公开(公告)日：1999-02-12

    申请号：ZA976723

    申请日：1997-07-29

    Applicant: BASF AG

    Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  GRIESINGER CHRISTIAN ,  BELIK DANIEL ,  BORETZKY MICHAEL

    IPC: A61K38/00 ,  A61P35/00 ,  C07K4/00 ,  C07K5/02 ,  C07K ,  A61K

    Abstract: The present invention provides anti-tumor peptides of Formula I,A-B-NR3-CHD-CH(OCH3)-CH2CO-E-K(I),and the acid salts thereof. A is an amino acid residue selected from the group consisting of N-methyl-D-prolyl, N-methyl-D-homoprolyl and N,N-dimethyl-2-ethylphenylglycyl, or an amino acid residue of the formula R1R2N-CHX-CO, wherein R1 is a-methyl group or an ethyl group, R2 is a hydrogen atom, a methyl group or an ethyl group, and X is an alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. R3 is a hydrogen atom or a methyl group. D is a normal or branched C2-C5-alkyl group. E is an amino acid residue selected from the group consisting of prolyl, homoprolyl, 5-methylprolyl, and phenylalanyl, or E is a residue derived from an amino acid comprising a pyrrolidine group. K is an alkoxy group or an amino group. An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of Formula I in a pharmaceutically acceptable composition.

    Dolastatin 15 derivatives
    52.
    发明专利
    Dolastatin 15 derivatives 未知

    公开(公告)号：AU8475898A

    公开(公告)日：1999-02-10

    申请号：AU8475898

    申请日：1998-07-07

    Applicant: BASF AG ,  BASF BIORESEARCH CORP

    Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

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