公开(公告)号：SI1040097T1

公开(公告)日：2004-10-31

申请号：SI9830659

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/38 ,  A61K31/44 ,  A61K31/47 ,  C07D211/84 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14

公开(公告)号：DK1259510T3

公开(公告)日：2004-10-04

申请号：DK01918338

申请日：2001-03-02

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DRIZIN IRENE ,  ALTENBACH ROBERT J

IPC: C07D491/147 ,  A61K31/437 ,  A61P1/00 ,  A61P7/12 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/06 ,  A61P15/08 ,  A61P15/10 ,  A61P17/14 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P43/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D471/04 ,  C07D491/14 ,  C07D495/14 ,  C07D498/04 ,  C07D498/14 ,  A61K31/4353 ,  A61P13/00 ,  C07D491/04

公开(公告)号：BG64309B1

公开(公告)日：2004-09-30

申请号：BG10459400

申请日：2000-07-11

Applicant: ABBOTT LAB

Inventor： CARROL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44 ,  A61K31/38

Abstract: The invention relates to compounds with the formula wherein the radicals have the meanings given in the description. They are useful in prevention, alleviation and treatment of diseases which are affected by potassium channel openers. The invention also relates to the application of the compounds for the preparation of medicamentous form, for opening potassium channels in mammals. 39 claims

公开(公告)号：BG63975B1

公开(公告)日：2003-08-29

申请号：BG10355399

申请日：1999-07-05

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The invention relates to alpha-1 adrenergic antagonists, to alpha -1 antagonistic compositions and to a method for the antagonization of alpha-1 adrenoreceptors applicable for the treatment of benignant hyperplasia of the prostate gland (BPH). The compound and its pharmaceutically aceeptable salts have the general formula where W means bicyclic heterocyclic ring system. 54 claims

公开(公告)号：AU764163B2

公开(公告)日：2003-08-14

申请号：AU1709500

申请日：1999-10-28

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  AGRIOS KONSTANTINOS A ,  ALTENBACH ROBERT J ,  DRIZIN IRENE ,  KORT MICHAEL E

IPC: C07D335/02 ,  A61K20060101 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D20060101 ,  C07D211/86 ,  C07D219/00 ,  C07D309/30 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/04 ,  C07D495/14 ,  C07D513/00 ,  A61K31/47 ,  A61P13/10 ,  A61P21/00 ,  A61P29/00

Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

公开(公告)号：AU756505B2

公开(公告)日：2003-01-16

申请号：AU1830799

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/38 ,  A61K31/44

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：DE69707497T2

公开(公告)日：2002-07-11

申请号：DE69707497

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA FATIMA ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  WENDT D ,  HAIGHT R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：ES2168682T3

公开(公告)日：2002-06-16

申请号：ES97951555

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：HU0104146A2

公开(公告)日：2002-04-29

申请号：HU0104146

申请日：1999-10-28

Applicant: ABBOTT LAB

Inventor： AGRIOS KONSTANTINOS A ,  ALTENBACH ROBERT J ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KORT MICHAEL E

IPC: C07D335/02 ,  A61K20060101 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D20060101 ,  C07D211/86 ,  C07D219/00 ,  C07D309/30 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/04 ,  C07D495/14 ,  C07D513/00

Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

公开(公告)号：CO5150163A1

公开(公告)日：2002-04-29

申请号：CO99067997

申请日：1999-10-27

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  KONSTANTINOS A AGRIOS ,  ALTENBACH ROBERT J ,  DRIZIN IRENE ,  KORT MICHAEL E

IPC: A61K20060101 ,  A61K31/395 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  C07D20060101 ,  C07D219/00 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07D513/00

Abstract: Un compuesto que tiene la fórmula I ó una sal, amida, éster, ó precursor de droga farmacéuticamente aceptables de éste, en donden es 0 - 1;m es 1- 2;A se selecciona del grupo conformado por NR2, O, y S;A´ se selecciona del grupo conformado por NR3, O, S, y CR4R5;D se selecciona del grupo conformado por CH2 y C(O);D´ se selecciona del grupo conformado por CH2, C(O), S(O), y S(O)2;R1 se selecciona del grupo conformado por aril y heterociclo;R2 y R3 son independientemente seleccionados del grupo conformado por hidrógeno, alcoxialquil, alquil, arilalquil, cicloalquil, cicloalquilalquil, haloalquil, heterocicloalquil, hidroxi, hidroxialquil, -NZ1Z2, y (NZ1Z2)alquil en donde Z1 y Z2 son independientemente seleccionados del grupo conformado por hidrógeno, alquil, alquilcarbonil, aril, arilalquil, y formil;R4 y R5 son independientemente seleccionados del grupo conformado por hidrógeno y alquil;R6 y R7 son independientemente seleccionados del grupo conformado por hidrógeno y alquil;con la condición de que cuando D sea CH2, entonces D´ es diferente a CH2; ycon la condición de que cuando D´ sea S(O) ó S(0)2 entonces A´ es CR4R5.