公开(公告)号：MX2011012257A

公开(公告)日：2011-12-16

申请号：MX2011012257

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： SOUERS ANDREW J ,  BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE ,  ELMORE STEVEN ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  SONG XIAOHONG ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WENDT MICHAEL ,  WANG XILU ,  MANTEI ROBERT ,  HANSEN TODD M

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.

公开(公告)号：SG175253A1

公开(公告)日：2011-11-28

申请号：SG2011075843

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE ,  ELMORE STEVEN ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL ,  MANTEI ROBERT ,  HANSEN TODD M

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：AU2010254160A1

公开(公告)日：2011-11-24

申请号：AU2010254160

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： MILAN BRUNCKO ,  HONG DING ,  GEORGE DOHERTY ,  STEVEN ELMORE ,  LISA HASVOLD ,  LAURA HEXAMER ,  KUNZER AARON R ,  XIAOHONG SONG ,  SOUERS ANDREW J ,  GERARD SULLIVAN ,  ZHI-FU TAO ,  WANG GARY T ,  LE WANG ,  XILU WANG ,  MICHAEL WENDT ,  ROBERT MANTEI ,  HANSEN TODD M

IPC: C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：UY32680A

公开(公告)日：2011-02-28

申请号：UY32680

申请日：2010-06-02

Applicant: ABBOTT LAB

Inventor： WANG GARY T ,  MANTEI ROBERT A ,  MILAN BRUNCKO ,  HONG DING ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  LISA HASVOLD ,  LAURA HEXAMER ,  KUNZER AARON R ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  XIAOHONG SONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  XILU WANG ,  WENDT MICHAEL D ,  HANSEN TODD M ,  LE WANG

IPC: A61P35/00 ,  C07D205/00 ,  C07D205/08 ,  C07D207/04 ,  C07D209/04 ,  C07D215/00 ,  C07D217/00 ,  C07D231/54 ,  C07D235/04 ,  C07D241/10 ,  C07D295/00 ,  C07D309/04 ,  C07D333/02 ,  C07D499/00

Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.

公开(公告)号：CA2763631A1

公开(公告)日：2010-12-02

申请号：CA2763631

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： CLARK RICHARD F ,  BELL RANDY L ,  BA-MAUNG NWE Y ,  ERICKSON SCOTT A ,  FIDANZE STEVE D ,  MANTEI ROBERT A ,  SHEPPARD GEORGE S ,  SORENSEN BRYAN K ,  WANG GARY T ,  WANG JIEYI

IPC: C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.

公开(公告)号：CA2763624A1

公开(公告)日：2010-12-02

申请号：CA2763624

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： CLARK RICHARD F ,  BA-MAUNG NWE Y ,  ERICKSON SCOTT A ,  FIDANZE STEVE D ,  MANTEI ROBERT A ,  SHEPPARD GEORGE S ,  SORENSEN BRYAN K ,  WANG GARY T ,  WANG JIEYI ,  BELL RANDY L

IPC: C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D403/14 ,  C07D487/04 ,  C07D513/04

Abstract: Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R1, R3, n, p, Ar1, and Ax2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR are also disclosed.

公开(公告)号：CA2759182A1

公开(公告)日：2010-12-02

申请号：CA2759182

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE ,  ELMORE STEVEN ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL ,  MANTEI ROBERT ,  HANSEN TODD M

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：PT1339695E

公开(公告)日：2006-08-31

申请号：PT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D233/00 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00

公开(公告)号：AT323681T

公开(公告)日：2006-05-15

申请号：AT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：AU2001268718B2

公开(公告)日：2006-01-05

申请号：AU2001268718

申请日：2001-06-22

Applicant: ABBOTT LAB

Inventor： GENTLES ROBERT ,  WANG GARY T ,  WANG SHELDON

IPC: C07D239/42 ,  C07D263/48 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/551 ,  A61P9/10 ,  A61P29/00 ,  A61P35/04 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/74 ,  C07D233/00 ,  C07D239/00 ,  C07D265/30 ,  C07D277/20 ,  C07D277/42 ,  C07D279/12 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/04

Abstract: The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.