公开(公告)号：DE102005031463A1

公开(公告)日：2007-01-11

申请号：DE102005031463

申请日：2005-07-04

Applicant: BASF AG

Inventor： MONTAG THORSTEN ,  KARL ULRICH ,  BAUS ULF ,  BOLLSCHWEILER CLAUS ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  KAROS MARVIN

IPC: C09D189/00 ,  C09K3/18

Abstract: In the reduction of evaporation rate of water, thickness of a barrier liquid is less than 1 mm. The barrier liquid has higher boiling point and lower density than the water. An independent claim is included for an open water reservoir.

公开(公告)号：CA2610785A1

公开(公告)日：2006-12-14

申请号：CA2610785

申请日：2006-05-31

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS ,  LEMAIRE HANS-GEORG ,  BAUS ULF ,  MONTAG THORSTEN ,  KAROS MARVIN ,  SUBKOWSKI THOMAS ,  SCHWENDEMANN VOLKER ,  BAUR RICHARD ,  MENDERA CHRISTINE

IPC: D06M15/15

Abstract: The invention relates to a method for coating fibre substrates selected form textile or leather substrates with the aid of at least one type of hydrophobin.

公开(公告)号：DE102005015043A1

公开(公告)日：2006-10-05

申请号：DE102005015043

申请日：2005-03-31

Applicant: BASF AG

Inventor： SEYFFER HERMANN ,  SCHUMACHER KARL-HEINZ ,  LEMAIRE HANS-GEORG ,  BAUS ULF ,  SUBKOWSKI THOMAS ,  KAROS MARVIN ,  BOLLSCHWEILER CLAUS ,  HEIDENFELDER THOMAS

IPC: C09J5/00 ,  B32B7/12 ,  C07K14/37 ,  C09J189/00

Abstract: The polypeptide contains 80 wt % of alpha amino acids and 0.5 wt % of cystein component. The adjacent layers and the substrate surface or the substrate-lateral surface of the coating consist of natural or nonpolar synthetic polymers with a surface tension of smaller than 50 mN/m. The amino acids comprise phenylalanine, leucine, serine, tyrosine, cysteine, tryptophan, proline, histidine, glutamine, arginine, isoleucine methionine, threonine, aspartagine, lysine, valaine, alanine, aspartic acid, glutamic acid and glycine. An independent claim is included for production of multilayer compound or coated substrate.

公开(公告)号：DE102005005737A1

公开(公告)日：2006-08-17

申请号：DE102005005737

申请日：2005-02-07

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

IPC: C07K14/195 ,  C07K14/38

Abstract: A new peptide is not connected in a natural manner with an external hydrophobin and has a contact angle of at least 20[deg] during coating of the glass surface. The structural formula of a new polypeptide is: X n-C 1>-X 1-50-C 2>-X 0-50-C 3>-X 1-100-C 4>-X 1-100-C 5>-X 1-50-C 6>-X 0-5-C 7>-X 1-50-C 8>-X m, where X : amino acids; n,m : 0 - 500 and; C : cysteine. The proviso is that at least one of the peptide sequences abbreviated by X n or X m is a peptide sequence of at least 20 amino acids in length. The peptide is not connected in a natural manner with an external hydrophobin and has a contact angle of at least 20[deg] during coating of a glass surface. Independent claims are included for: (1) nucleic acid coding for polypeptide; and (2) procedure of polypeptide production by expressing the above nucleic acid in a host organism and isolating the obtained protein.

公开(公告)号：DK0725822T3

公开(公告)日：2000-12-04

申请号：DK94929554

申请日：1994-10-17

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： SCHWEDEN JUERGEN ,  BOLLSCHWEILER CLAUS ,  PIONTEK MICHAEL ,  WEYDEMANN ULRIKE ,  GELLISSEN GERD

IPC: C12N15/09 ,  C07K14/815 ,  C12N15/16 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865

Abstract: A process for the recombinant production of proteins in yeast comprises transforming the yeast with an expression cassette which comprises the following structural elements encoded:L-A-P-GENwhere L is a leader sequence of an animal peptide neurohormone, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.

公开(公告)号：PT716705E

公开(公告)日：2000-09-29

申请号：PT94927528

申请日：1994-09-01

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： JANOWICZ ZBIGNIEW A ,  PIORKOWSKI MICHAEL J ,  SCHWEDEN JUERGEN ,  BOLLSCHWEILER CLAUS ,  WEYDEMANN ULRIKE ,  STRASSER ALEXANDER W M

IPC: C12N15/09 ,  C07K14/815 ,  C12N1/19 ,  C12N9/34 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/78

Abstract: PCT No. PCT/EP94/02897 Sec. 371 Date Mar. 1, 1996 Sec. 102(e) Date Mar. 1, 1996 PCT Filed Sep. 1, 1994 PCT Pub. No. WO95/07356 PCT Pub. Date Mar. 16, 1995A process for the recombinant production of proteins in the yeast Hansenula comprises transforming Hansenula with an expression cassette which comprises the following structural elements encoded: L-A-P-GEN where L is a leader sequence, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.

公开(公告)号：BR9707280A

公开(公告)日：1999-07-20

申请号：BR9707280

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：ZA9701107B

公开(公告)日：1998-08-11

申请号：ZA9701107

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K ,  A61K ,  C07H

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

公开(公告)号：NO983677L

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  H FFKEN HANS WOLFGANG ,  SCHWEDEN J RGEN ,  R BSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：BR9507231A

公开(公告)日：1997-09-16

申请号：BR9507231

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  REICHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I