公开(公告)号：DE59209604D1

公开(公告)日：1999-02-11

申请号：DE59209604

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：NO983677D0

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C12N

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：HRP970077A2

公开(公告)日：1998-04-30

申请号：HRP970077

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：DK0609242T3

公开(公告)日：1997-01-06

申请号：DK92919916

申请日：1992-09-21

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  A61K37/64

公开(公告)号：CA2121601A1

公开(公告)日：1993-06-10

申请号：CA2121601

申请日：1992-11-19

Applicant: BASF AG

Inventor： STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  FRIEDRICH THOMAS

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  A61K38/58

Abstract: 2121601 9311239 PCTABS00022 Described are new thrombin-inhibiting proteins obtained from terrestrial leeches of the species Haemadipsa and with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-A_ sp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly_ -Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys or an amino-acid sequence obtained by C-terminal shortening the above sequence by one to twelve amino acids. The proteins are suitable for use against illnesses. Also described are the nucleic acids coding for these proteins.

公开(公告)号：MX9206732A

公开(公告)日：1993-05-01

申请号：MX9206732

申请日：1992-11-23

Applicant: BASF AG

Inventor： STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  FRIEDRICH THOMAS

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  C07K15/08

Abstract: PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.

公开(公告)号：MX9203832A

公开(公告)日：1993-01-01

申请号：MX9203832

申请日：1992-06-30

Applicant: BASF AG

Inventor： BRAATZ REIHARD ,  KURTH ROLAND ,  MANKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573 ,  A61K39/104

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：CA2347521C

公开(公告)日：2010-02-23

申请号：CA2347521

申请日：1999-10-13

Applicant: BASF AG

Inventor： RESS-LOSCHKE MARION ,  FRIEDRICH THOMAS ,  HAUER BERNHARD ,  MATTES RALF ,  ENGELS DIRK

IPC: C12N9/78 ,  C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N15/55 ,  C12N15/63 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide with nitrilase activity, to nucleic acid constructs containing the nucleic acid sequences, and to vectors containing the nucleic acid sequences or the nucleic acid constructs. The invention also relates to amino acid sequences which are coded by the nucleic acid sequences, and to microorganisms containing the nucleic acid sequences, the nucleic acid constructs or vectors containing the nucleic acid sequences or the nucleic acid constructs. In addition, the invention relates to a method for producing chiral carboxylic acids from the racemic nitriles.

公开(公告)号：NO327857B1

公开(公告)日：2009-10-05

申请号：NO20011912

申请日：2001-04-18

Applicant: BASF AG

Inventor： MATTES RALF ,  FRIEDRICH THOMAS ,  HAUER BERNHARD ,  RESS-LOSCHKE MARION ,  ENGELS DIRK

IPC: C07H21/00 ,  C12N9/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/55 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

公开(公告)号：EE05008B1

公开(公告)日：2008-04-15

申请号：EEP200100232

申请日：1999-10-13

Applicant: BASF AG

Inventor： RESS-LOESCHKE MARION ,  FRIEDRICH THOMAS ,  HAUER BERNHARD ,  MATTES RALF ,  ENGELS DIRK

IPC: C12N9/78 ,  C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N15/55 ,  C12N15/63 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.