公开(公告)号：AU2009316756B2

公开(公告)日：2016-02-25

申请号：AU2009316756

申请日：2009-11-18

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  SHANNON DEAN ,  LIANG JIANGLIN

IPC: C07D513/04 ,  A61K31/433

Abstract: The present invention relates to compound (1), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound (1) and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：HRP20130986T1

公开(公告)日：2013-11-22

申请号：HRP20130986

申请日：2013-10-17

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

公开(公告)号：SI2332940T1

公开(公告)日：2013-03-29

申请号：SI200531659

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT ,  WANG JIAN

IPC: C07D471/00 ,  C07D519/00

公开(公告)号：NZ592825A

公开(公告)日：2013-01-25

申请号：NZ59282509

申请日：2009-11-18

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  SHANNON DEAN ,  LIANG JIANGLIN

IPC: C07D513/04 ,  A61K31/433

Abstract: 592825 Disclosed is 6-((S)-I-(6-(I-methyl-IH-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b ][1,3,4]thiadiazol-3-yl)ethyl)quinoline (compound 1). Aldo disclosed are compositions comprising compound 1 and the use of compound 1 for the manufacture of a medicament for treating or lessening the severity of a proliferative disorder in a patient, in particular glioblastoma; a gastric carcinoma; or a cancer selected from colon, breast, prostate, brain, liver, pancreatic or lung cancer.

公开(公告)号：AU2005228904C1

公开(公告)日：2012-12-13

申请号：AU2005228904

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： COURT JOHN ,  ROBINSON DANIEL ,  CHARRIER JEAN-DAMIEN ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  LAUFFER DAVID ,  BETHIEL RANDY ,  FARMER LUC ,  HARRINGTON EDMUND ,  COME JON ,  GREEN JEREMY ,  EVERITT SIMON ,  BINCH HAYLEY ,  SALITURO FRANCESCO ,  PIERARD FRANCOISE ,  ARONOV ALEX ,  BOYALL DEAN ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2005228904B8

公开(公告)日：2012-08-02

申请号：AU2005228904

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： COURT JOHN ,  ROBINSON DANIEL ,  CHARRIER JEAN-DAMIEN ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  LAUFFER DAVID ,  BETHIEL RANDY ,  FARMER LUC ,  HARRINGTON EDMUND ,  COME JON ,  GREEN JEREMY ,  EVERITT SIMON ,  BINCH HAYLEY ,  SALITURO FRANCESCO ,  PIERARD FRANCOISE ,  ARONOV ALEX ,  BOYALL DEAN ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHEN ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2005228904B2

公开(公告)日：2012-05-10

申请号：AU2005228904

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： COURT JOHN ,  ROBINSON DANIEL ,  CHARRIER JEAN-DAMIEN ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  LAUFFER DAVID ,  BETHIEL RANDY ,  FARMER LUC ,  HARRINGTON EDMUND ,  COME JON ,  GREEN JEREMY ,  EVERITT SIMON ,  BINCH HAYLEY ,  SALITURO FRANCESCO ,  PIERARD FRANCOISE ,  ARONOV ALEX ,  BOYALL DEAN

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：NZ584311A

公开(公告)日：2012-03-30

申请号：NZ58431108

申请日：2008-09-30

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  WAAL NATHAN ,  MCGINTY KIRA ,  TANG QING ,  RONKIN STEVEN ,  FARMER LUC ,  SHANNON DEAN ,  JACOBS DYLAN

IPC: A61P35/00 ,  A61K31/4439 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14

Abstract: Disclosed are tetrazole compounds of formula (I), or pharmaceutically acceptable salts thereof, and methods for their preparation. R5 of the compound of formula (I) is a substituted carbon, and contributes to the compounds' decreased IC50 with respect to hydrogen-substituted analogues. Also disclosed is using compound of formula (I) for treating or lessening the severity of a proliferative disorder in a patient, wherein the proliferative disorder is metastatic cancer, glioblastoma; a gastric carcinoma, atherosclerosis or lung fibrosis or a cancer selected from colon, breast, prostate, brain, liver, pancreatic or lung cancer. Also disclosed is a method of inhibiting c-MET protein kinase activity in a biological sample in vitro comprising contacting said biological sample with a compound of formula (I).

公开(公告)号：RS51830B

公开(公告)日：2012-02-29

申请号：RSP20110341

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：SG176574A1

公开(公告)日：2012-01-30

申请号：SG2011085578

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.