公开(公告)号：EP0353591A2

公开(公告)日：1990-02-07

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

公开(公告)号：EP0329061A2

公开(公告)日：1989-08-23

申请号：EP89102478.8

申请日：1989-02-14

Applicant: APPLIED BIOSYSTEMS, INC.

Inventor： Sapp, Edwin R. ,  Kinast, Eric K.

IPC: G01N21/27 ,  G01J1/16 ,  G01J3/42

CPC classification number: G01N21/27 ,  G01J3/2803 ,  G01J3/42 ,  G01J2001/161 ,  G01J2001/1673 ,  G01N30/74 ,  G01N2201/1232 ,  G01N2201/126

Abstract: The present invention relates to an improved dual beam multichannel spectrophotomer employing a simple and novel optical system in combination with photodiode arrays and a unique logrithmic data converter to convert light signals to absorbance. In particular, the optical system utilizes optical elements in a novel arrangement to direct a pair of equivalent sample and reference beams in an essentially parallel formation respectively through a sample and reference cell and to focus and direct the emergent sample and reference beams to a single flat horizontally ruled grating which disperses each of the sample and reference beams respectively onto a pair of vertically disposed photodiode arrays whereby the light signals are converted into absorbance units (AU) by an unique logarithmic data converter. The spectrophotometer is highly accurate, has very low drift, less than 2 x 10⁻⁴ AU/°C, and very low noise, less than ±2 x 10⁻⁵AU. The dual beam multichannel spectrophotomer is particularly suitable for use in high pressure liquid chromatography to record the absorbance spectrum of the samples as they are being eluted from the chromatographic column.

Abstract translation: 本发明涉及一种改进的双光束多通道分光光度计，其采用与光电二极管阵列组合的简单且新颖的光学系统以及将光信号转换成吸光度的唯一的对数数据转换器。 特别地，光学系统利用新颖的布置中的光学元件来分别通过样品和参考单元引导基本上平行的一对等效样品和参考光束，并将出射样品和参考光束聚焦并引导到单个平面 将每个样本和参考光束分别分散在一对垂直设置的光电二极管阵列上的水平格栅光栅，由此光信号通过独特的对数数据转换器转换成吸光度单位（AU）。 分光光度计是高精度的，具有非常低的漂移，小于2×10 -4 AU /℃，噪音非常低，小于+/- 2×10 <5> AU。 双光束多通道分光光度计特别适用于高压液相色谱，以记录样品从色谱柱中洗脱的吸收光谱。

公开(公告)号：EP0304230A2

公开(公告)日：1989-02-22

申请号：EP88307458.5

申请日：1988-08-11

Applicant: THE BRITISH PETROLEUM COMPANY P.L.C.

Inventor： Hilliard, Lorelli Alison ,  Theocharous, Evangelos

IPC: G01N21/31 ,  G01N33/22

CPC classification number: G01N21/314 ,  G01J2001/161 ,  G01J2001/4433 ,  G01N21/85 ,  G01N2021/3166

Abstract: A process for spectroscopically measuring the content of a component in a liquid mixture involves passing a single optical beam through the mixture without the use of a reference beam and measuring the intensitites of transmitted light in two different wavelength bands by means of two adjacent detectors responsive to light in the two wavelength bands respectively. The component being measured absorbs light within one of the wavelength bands. The ratio of the detector outputs can then be related to the component concentration. The principal use of the invention is for in-situ measurement of methanol in gasoline for motor vehicles.

Abstract translation: 用于光谱测量液体混合物中的组分含量的方法包括使单个光束通过混合物而不使用参考光束，并且通过两个相邻的检测器测量两个不同波长带中的透射光的强度，所述相邻检测器响应于 分别在两个波长带的光。 所测量的组分吸收一个波长带内的光。 然后检测器输出的比率可以与组分浓度相关。 本发明的主要用途是用于机动车辆的汽油中甲醇的原位测量。

公开(公告)号：EP0497434A3

公开(公告)日：1992-12-16

申请号：EP92201182.0

申请日：1989-02-14

Applicant: APPLIED BIOSYSTEMS, INC.

Inventor： Sapp, Edwin R. ,  Kinast, Eric K.

IPC: G01N21/27 ,  G01J1/16 ,  G01J3/42

CPC classification number: G01N21/27 ,  G01J3/2803 ,  G01J3/42 ,  G01J2001/161 ,  G01J2001/1673 ,  G01N30/74 ,  G01N2201/1232 ,  G01N2201/126

Abstract: The present invention relates to an improved dual beam multichannel spectrophotomer employing a simple and novel optical system in combination with photodiode arrays and a unique logrithmic data converter to convert light signals to absorbance. In particular, the optical system utilizes optical elements in a novel arrangement to direct a pair of equivalent sample and reference beams in an essentially parallel formation respectively through a sample and reference cell and to focus and direct the emergent sample and reference beams to a single flat horizonatally ruled grating which disperses each of the sample and reference beams respectively onto a pair of vertically disposed photodiode arrays whereby the light signals are converted into absorbance units (AU) by an unique logarithmic data converter. The spectrophotometer is highly accurate, has very low drift, less than 2 x 10⁻⁴ AU/°C, and very low noise, less than ±2 x 10⁻⁵AU. The dual beam multichannel spectrophotomer is particularly suitable for use in high pressure liquid chromatography to record the absorbance spectrum of the samples as they are being eluted from the chromatographic column.

公开(公告)号：EP0446859A1

公开(公告)日：1991-09-18

申请号：EP91103739.8

申请日：1991-03-12

Applicant: Sankyo Company Limited ,  HORIBA, LTD.

Inventor： Saito, Yukio ,  Sekiya, Koichi ,  Sato, Yoshihiro ,  Kohno, Takeshi ,  Takahasi, Hiroaki, 11-202, Ogurusu Kita Danti ,  Terada, Kunio ,  Aoki, Takayuki

IPC: G01N21/27 ,  G01N33/53

CPC classification number: G01N21/274 ,  G01J2001/161 ,  G01J2001/1663 ,  G01N21/76

Abstract: The present invention relates to a chemical luminescence-detecting apparatus in which an intensity of chemical luminescence generated in a photometric cell (41) is detected by a plurality of optical detectors (52, 53). The optical detectors (52, 53) are different in sensitivity an a ratio (A) of outputs (I r , i r ) from said optical detectors (52, 53) based on said intensity of luminescence is previously determined followed by multiplying said outputs (i r ) of low sensitivity optical detectors (53) by a factor determined by said ratio (A) to measure the intensity of luminescence so that a conversion value corresponding to outputs from high sensitivity optical detectors (52) may be obtained when said outputs from said high sensitivity optical detectors (52) have been saturated.

Abstract translation: 本发明涉及一种化学发光检测装置，其中通过多个光学检测器（52,53）检测在测光单元（41）中产生的化学发光的强度。 光检测器（52,53）的灵敏度不同，预先确定基于所述发光强度的来自所述光学检测器（52,53）的输出（Ir，ir）的比率（A），然后乘以所述输出（ir ）通过由所述比率（A）确定的因子来测量低灵敏度光学检测器（53），以测量发光强度，使得当所述高电平的所述输出从所述高灵敏度光检测器（52）的输出 灵敏度光学检测器（52）已经饱和。

公开(公告)号：EP0353591A3

公开(公告)日：1991-03-20

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0304230A3

公开(公告)日：1989-12-20

申请号：EP88307458.5

申请日：1988-08-11

Applicant: THE BRITISH PETROLEUM COMPANY P.L.C.

Inventor： Hilliard, Lorelli Alison ,  Theocharous, Evangelos

IPC: G01N21/31 ,  G01N33/22

CPC classification number: G01N21/314 ,  G01J2001/161 ,  G01J2001/4433 ,  G01N21/85 ,  G01N2021/3166

Abstract: A process for spectroscopically measuring the content of a component in a liquid mixture involves passing a single optical beam through the mixture without the use of a reference beam and measuring the intensitites of transmitted light in two different wavelength bands by means of two adjacent detectors responsive to light in the two wavelength bands respectively. The component being measured absorbs light within one of the wavelength bands. The ratio of the detector outputs can then be related to the component concentration. The principal use of the invention is for in-situ measurement of methanol in gasoline for motor vehicles.

公开(公告)号：EP0335915A1

公开(公告)日：1989-10-11

申请号：EP88902688.0

申请日：1988-02-29

Applicant: ELECTRONIC INSTRUMENTATION AND TECHNOLOGY, INC.

Inventor： MAY, Joe, T. ,  CASACIA, Edward, A.

IPC: G01N21 ,  G01J1

CPC classification number: G01N21/251 ,  G01J1/1626 ,  G01J2001/161 ,  G01N21/8507 ,  G01N2201/0693 ,  G01N2201/12761

Abstract: A portable, battery powered instrument for measuring the amount of material dissolved in a liquid solution employs electro-optic technology based on the Beer-Lambert Law. A sample probe (14) is inserted in a solution to be measured. The results of the measurement are displayed on a display (22). The displayed results are frozen for a predetermined period of time at the expiration of which, the power is turned off to conserve battery power.

公开(公告)号：EP0237310A2

公开(公告)日：1987-09-16

申请号：EP87302005.1

申请日：1987-03-09

Applicant: DIONEX CORPORATION

Inventor： Tullsen, Thomas R.

IPC: H03G3/20 ,  G01N30/86 ,  G01J1/18

CPC classification number: G01N30/8665 ,  G01J1/16 ,  G01J2001/161 ,  G01J2001/4406 ,  G01N30/74 ,  G01N2021/174 ,  G01N2030/626

Abstract: An optical detector provides automatic zeroing of a logarithmic ratio function in applications such as absorption meters, fluorometers and other chromatographic techniques.

Abstract translation: 提供光学检测器。 光学检测器在诸如吸收计，荧光计和其他色谱技术的应用中提供对数比例功能的自动归零。

公开(公告)号：EP0176826A3

公开(公告)日：1987-09-02

申请号：EP85111475

申请日：1985-09-11

Applicant: KOLLMORGEN TECHNOLOGIES CORPORATION

Inventor： Kravetz, Alan G. ,  Kishner, Stanley J.

IPC: G01J03/42

CPC classification number: G01N21/5907 ,  G01J1/36 ,  G01J2001/161 ,  G01N2021/5992

Abstract: In the measurement of the optical transmittance of a sample, a beam which is split from a source of illumination is . directed through the sample and then redirected back through the sample. The redirected beam and a reference beam which is also split from the source of illumination are alternately applied to a photodetector. Both the sample beam and the reference beam pass through a monochromator prior to application to the photodetector. The output of the photodetector is processed by an electronic circuit and applied to a computer. Data representative of the two beams can be compared in order to provide an indication of the amount of light the sample transmits at certain optical wavelengths.

Abstract translation: 在测量样品的光透射率时，从照明源分离的光束被引导通过样品，然后被重新定向回通过样品。 重新定向的光束和也从光源分割的参考光束被交替地施加到光电检测器。 在施加到光电检测器之前，采样光束和参考光束都通过单色仪。 光电检测器的输出由电子电路处理并应用于计算机。 可以比较表示两个光束的数据，以便提供样品在某些光波长处透射的光量的指示。