公开(公告)号：KR101359518B1

公开(公告)日：2014-02-07

申请号：KR1020120049237

申请日：2012-05-09

Applicant: 한국화학연구원

Inventor： 박보근 ,  정택모 ,  김창균 ,  전동주 ,  김효숙 ,  이영국 ,  안기석 ,  이선숙 ,  임종선

IPC: C01F5/02 ,  C01F5/00 ,  C23C16/18

CPC classification number: C23C16/403

Abstract: 본 발명은 하기 화학식1로 표시되는 산화 마그네슘 전구체에 관한 것으로, 상기 산화 마그네슘 전구체는 열적으로 안정하고 휘발성이 좋으므로 양질의 산화 마그네슘을 포함한 박막을 형성할 수 있다.
[화학식 1]

公开(公告)号：KR1020130123919A

公开(公告)日：2013-11-13

申请号：KR1020120047440

申请日：2012-05-04

Applicant: 한국화학연구원

Inventor： 박보근 ,  정택모 ,  김창균 ,  조지,쉐비메리 ,  전동주 ,  안기석 ,  이선숙

IPC: C07F3/00 ,  C23C16/18

CPC classification number: C07F3/00 ,  C23C16/409 ,  C23C16/45525

Abstract: The present invention relates to a strontium precursor which is represented by chemical formula 1, is thermally stable, and has good volatility, thereby easily forming a thin film including good quality strontium. In chemical formula 1, each of R1, R2, R3, R4, and R5 is independently H or a C1-C10 linear or branched alkyl group; each of R6 and R7 is independently a C1-C10 linear or branched alkyl group or a C1-C10 alkyl fluoride group.

Abstract translation: 本发明涉及由化学式1表示的锶前体，其热稳定性良好，挥发性良好，容易形成包含质量好的锶的薄膜。 在化学式1中，R 1，R 2，R 3，R 4和R 5各自独立地为H或C 1 -C 10直链或支链烷基; R6和R7各自独立地为C1-C10直链或支链烷基或C1-C10烷基氟基团。

公开(公告)号：KR100838692B1

公开(公告)日：2008-06-16

申请号：KR1020070069765

申请日：2007-07-11

Applicant: 한국화학연구원

Inventor： 전동주 ,  송종환 ,  이계형 ,  김익연

IPC: C07D487/04 ,  A61K31/52 ,  A61P29/00

Abstract: A novel 7-(3',4'-dialkoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine compound is provided to show excellent inhibitory activity and high enzyme selectivity on PDE-4 enzyme, thereby being used in order to prevent and treat inflammation related diseases, arthritis, atopic dermatitis, tumor, and brain diseases. A 7-(3',4'-dialkoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine compound is represented by a formula(1), wherein each R1 and R2 is independently H, linear or branched saturated or unsaturated C1-7 alkyl, linear or branched saturated or unsaturated C1-7 alkyl including O, N or S, C3-7 cycloalkyl, C3-7 cycloalkyl including O, N or S, (C3-7)cycloalkyl(C1-7)alkyl, 3 to 7-membered saturated or unsaturated heterocycloalkyl including O, N or S in a hetero-ring, phenyl or benzyl, or R1 and R2 may be linked to each other by C1-3 alkylene or C1-3 alkylene including halogen; each R3 and R4 is independently H, formyl, halogen, linear or branched saturated or unsaturated C1-7 alkyl. C1-7 alkoxy, C3-7 cycloalkyl, (C1-7)alkoxy(C1-7)alkyl, C1-7 alkyl ketone, hydroxy(C1-7)alkyl, (C3-7)cycloalkyl(C1-7)alkyl, (C3-7)cycloalkyl(C1-7)alkoxy, C1-7 alkyl carboxyl, carboxy(C1-10)alkylester, carboxyl(C1-10)alkylamide, amino, mono or di(C1-7)alkylamino, mono or di(C1-7)alkylaminocarbonyl, (C3-7)cycloalkylamino, morpholine, morpholine oxide, thio- morpholine, piperidine, piperazine, piperazine oxide, piperidine, piperidine oxide, pyrrolidine, cyano, nitro, carboxyl, guanidine, urea, phenoxy, benzyloxy or aryl represented by Ar; and R5 is H, linear or branched saturated or unsaturated C1-7 alkyl, C3-7 cycloalkyl, (C1-7)alkoxy(C1-7)alkyl, (C3-7)cycloalkyl(C1-7)alkyl, (C3-7)cycloalkyl(C1-7)alkoxy, mono or di(C1-7)alkylamino, carbonyl, cyano, C1-7 alkoxycarbonyl, aminocarbonyl, C1-7 alkylcarbonyl, (C6-10)ar(C1-7)alkylcarbonyl or C6-10 arylcarbonyl. A method for preparing the compound of the formula(1) comprises the steps of: (a) after reacting a 3-amino-5-substituted pyrazole compound represented by a formula(4) with a 3-(dimethylamino)-1-(3,4-dialkoxyphenyl)prophenone compound represented by a formula(5) or a 3-(3,4-dialkoxyphenyl)cinnamic aldehyde compound represented by a formula(6) in the presence of an acetic acid, reducing a reaction producing with NaBH4 to prepare a compound represented by the formula(1); and (b) subjecting the compound of a formula(10) to nucleophilic substitution. A pharmaceutical composition for treating or preventing asthma, chronic obstructive pulmonary disease, arthritis, atopic dermatitis, tumor and degenerative brain diseases comprises the compound of the formula(1) or a pharmaceutically acceptable salt thereof.

Abstract translation: 提供了一种新型的7-（3'，4'-二烷氧基苯基）-4,5,6,7-四氢吡唑并[1,5-a]嘧啶化合物，以显示优异的抑制活性和对PDE-4酶的高酶选择性 用于预防和治疗炎症相关疾病，关节炎，特应性皮炎，肿瘤和脑疾病。 7-（3'，4'-二烷氧基苯基）-4,5,6,7-四氢吡唑并[1,5-a]嘧啶化合物由式（1）表示，其中每个R 1和R 2独立地为H，线性 或支链饱和或不饱和C 1-7烷基，包括O，N或S，C 3-7环烷基的直链或支链饱和或不饱和C 1-7烷基，包括O，N或S的C 3-7环烷基，（C 3-7）环烷基（ C 1-7烷基，含有杂环中O，N或S的3至7元饱和或不饱和杂环烷基，苯基或苄基，或R 1和R 2可以通过C 1-3亚烷基或C 1-3 包括卤素的亚烷基; 每个R 3和R 4独立地是H，甲酰基，卤素，直链或支链饱和或不饱和的C 1-7烷基。 C 1-7烷氧基，C 3-7环烷基，（C 1-7）烷氧基（C 1-7）烷基，C 1-7烷基酮，羟基（C 1-7）烷基，（C 3-7）环烷基（C 1-7）烷基， （C 3-7）环烷基（C 1-7）烷氧基，C 1-7烷基羧基，羧基（C 1-10）烷基酯，羧基（C 1-10）烷基酰胺，氨基，单或二（C 1-7）烷基氨基，单或二 （C 1-7）烷基氨基羰基，（C 3-7）环烷基氨基，吗啉，吗啉氧化物，硫代吗啉，哌啶，哌嗪，哌嗪氧化物，哌啶，哌啶氧化物，吡咯烷，氰基，硝基，羧基，胍，脲，苯氧基， 或由Ar表示的芳基; 并且R 5为H，直链或支链饱和或不饱和的C 1-7烷基，C 3-7环烷基，（C 1-7）烷氧基（C 1-7）烷基，（C 3-7）环烷基（C 1-7） 7）环烷基（C 1-7）烷氧基，一或二（C 1-7）烷基氨基，羰基，氰基，C 1-7烷氧基羰基，氨基羰基，C 1-7烷基羰基，（C 6-10）芳（C 1-7）烷基羰基或C 6 -10芳基羰基。 制备式（1）化合物的方法包括以下步骤：（a）使由式（4）表示的3-氨基-5-取代的吡唑化合物与3-（二甲基氨基）-1-（ （5）表示的丙烯酮化合物或由式（6）表示的3-（3,4-二烷氧基苯基）肉桂醛化合物在乙酸存在下还原产生的反应 以制备由式（1）表示的化合物; 和（b）使式（10）的化合物进行亲核取代。 用于治疗或预防哮喘，慢性阻塞性肺病，关节炎，特应性皮炎，肿瘤和退行性脑疾病的药物组合物包含式（1）化合物或其药学上可接受的盐。

公开(公告)号：KR100477892B1

公开(公告)日：2005-03-18

申请号：KR1020030026416

申请日：2003-04-25

Applicant: 한국화학연구원

Inventor： 전동주 ,  김형래 ,  송종환 ,  박관용 ,  정순민 ,  황인택

IPC: A01N43/90

Abstract: 본 발명은 다음 화학식 1로 표시되는 신규의 9-(5-이속사졸메톡시페닐)이미노-8-치아-1,6-디아자비시클로[4.3.0]노난-7-온 유도체와 이들을 유효성분으로 포함하는 제초제에 관한 것이다.

상기 화학식 1에서, R은 C
1 ∼C
5 의 알킬기, 페닐기 또는 치환된 페닐기이고, 이때 치환된 페닐기는 C
1 ∼C
3 의 알킬기, C
1 ∼C
3 의 알콕시기, 할로겐 원자, 시아노기, 니트로기, 카르복실기 및 카르복실산 에스테르기 중에서 선택된 치환기가 1 ∼ 3개 단일 혹은 복합적으로 치환된 페닐기이다.

公开(公告)号：KR100454090B1

公开(公告)日：2004-10-26

申请号：KR1020020033207

申请日：2002-06-14

Applicant: 한국화학연구원

Inventor： 유응걸 ,  전동주 ,  김형래 ,  송종환 ,  박관용

IPC: C07D231/54

Abstract: PURPOSE: A process for preparing 3-chloro-2- (4-chloro-2-fluoro-5-hydroxyphenyl)- 4,5,6,7-tetrahydro-2H-indazole is provided, thereby improving its preparation yield and converting by-products of the preparation into starting material. CONSTITUTION: A process for preparing 3-chloro-2- (4-chloro-2-fluoro-5-hydroxyphenyl)- 4,5,6,7-tetrahydro-2H-indazole of the formula 1 comprises the steps of: reacting 2- (2-fluoro-4-chloro-5-hydroxyphenyl)- 2,3a,4,5,6,7- hexahydroindazole-3-one of the formula 2 with phosgene; concentrating the phosgene reaction mixture under reduced pressure; dissolving the concentrate in an organic solvent; adding ammonia water or hydroxide solution to the organic solvent and filtering solids; and distilling the filtrated solution, wherein the organic solvent is ethylacetate; the addition of ammonia water or hydroxide solution is carried out at room temperature; the solids are mainly constituted of a compound of the formula 2, and the by-products of the reaction include a dimer represented by the formula 3a, 3b or 3c.

Abstract translation: 目的：提供一种制备3-氯-2-（4-氯-2-氟-5-羟基苯基）-4,5,6,7-四氢-2H-吲唑的方法，由此提高其制备产率和通过 - 将制剂的产物制成原料。 构成：制备式1的3-氯-2-（4-氯-2-氟-5-羟基苯基）-4,5,6,7-四氢-2H-吲唑的方法包括以下步骤：使2 - （2-氟-4-氯-5-羟基苯基）-2,3a，4,5,6,7-六氢吲唑-3-酮与光气的反应; 在减压下浓缩光气反应混合物; 将浓缩物溶解在有机溶剂中; 向有机溶剂中加入氨水或氢氧化物溶液并过滤固体; 蒸馏过滤后的溶液，其中有机溶剂为乙酸乙酯; 氨水或氢氧化钠溶液的加入在室温下进行; 固体主要由式2的化合物构成，并且反应的副产物包括由式3a，3b或3c表示的二聚体。

公开(公告)号：KR100392072B1

公开(公告)日：2003-07-22

申请号：KR1020000052917

申请日：2000-09-07

Applicant: 한국화학연구원

Inventor： 유응걸 ,  김형래 ,  전동주 ,  송종환 ,  김경만 ,  이정노 ,  김형철 ,  홍경식

IPC: A01N43/80

CPC classification number: A01N43/80

Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.

Abstract translation: 本发明提供了式（1）的新型5-苄氧基甲基-1,2-异恶唑啉衍生物及其制备方法和它们作为除草剂的用途。 即使在低剂量率下，本发明的5-苄氧基甲基-1,2-异恶唑啉衍生物对稻田杂草具有足够高的除草活性，特别是对转移的稻米具有优异的选择性。 因此，本发明的化合物通常可用作除草剂以控制稻中的稻田杂草。

公开(公告)号：KR1020000059735A

公开(公告)日：2000-10-05

申请号：KR1019990007558

申请日：1999-03-08

Applicant: 한국화학연구원

Inventor： 유응걸 ,  송종환 ,  김형래 ,  전동주 ,  정정애 ,  김경만 ,  김태준

IPC: C07D413/12

Abstract: PURPOSE: A N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is provided which has excellent stability against a rice plant and shows good herbicidal activity on weeds in a paddy like echor, scpju, moova, cypse, sagpy or so on. CONSTITUTION: The N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is shown in a chemical formula 1 wherein R is alkyl radical with 1-5 carbon number, phenyl radical or substituted phenyl radical, cyano radical, carboxylic acid or carboxylic ester, heterocyclic or substituted heterocyclic radical. The substituted phenyl radical or substituted heterocyclic radical is simply or mixedly substituted from 1-3 radicals among alkyl radical with 1-3 carbon number, alkoxy radial with 1-3 carbon number, halogen atom, cyano radical, nitro radical, carboxyl radical and carboxylic ester.

Abstract translation: 目的：提供一种对水稻植株具有优异稳定性的N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物，对水稻，scpju，moova，cypse，sagpy等中的杂草具有良好的除草活性。 组成：N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物以化学式1表示，其中R是具有1-5个碳数的烷基，苯基或取代的苯基，氰基，羧酸或羧酸酯，杂环或 取代的杂环基。 取代的苯基或取代的杂环基团在具有1-3个碳原子的烷基，具有1-3个碳数的烷氧基，卤素原子，氰基，硝基，羧基和羧基的烷基中简单或混合取代1-3个基团 酯。

公开(公告)号：KR100250838B1

公开(公告)日：2000-05-01

申请号：KR1019970065411

申请日：1997-12-02

Applicant: 한국화학연구원

Inventor： 전동주 ,  유응걸 ,  김경만

IPC: C07D307/08

Abstract: PURPOSE: Provided is a preparation method of 3(-(hydroxymethyl)tetrahydrofuran) represented by the formula (1) which is used as an intermediate raw material of drugs and insecticide. Thereby the compound is simply and easily prepared compared to the conventional methods. CONSTITUTION: (3-(hydroxymethyl)tetrahydrofuran) of the formula (1) is prepared by cyclization reaction of 2-hydroxymethyl-4-alkene-1-ol derivative of the formula (2) in the presence of I2 catalyst in organic solvent, wherein R1, R2 and R3 are C1-C4 alkyl or phenyl selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl and t-butyl, respectively.

Abstract translation: 目的：提供用作药物和杀虫剂的中间体原料的由式（1）表示的3（ - （羟甲基）四氢呋喃）的制备方法。 因此，与常规方法相比，化合物简单且容易地制备。 组成：通式（2）的2-羟甲基-4-烯-1-醇衍生物在有机溶剂中存在的I2催化剂的环化反应制备式（1）的（3-（羟甲基）四氢呋喃） 其中R1，R2和R3分别是C1-C4烷基或选自氢，甲基，乙基，正丙基，异丙基，正丁基，异丁基和叔丁基的苯基。

公开(公告)号：KR100248945B1

公开(公告)日：2000-04-01

申请号：KR1019970065413

申请日：1997-12-02

Applicant: 한국화학연구원

Inventor： 유응걸 ,  전동주 ,  유동욱 ,  박현주 ,  김형래 ,  송종환 ,  신승일 ,  홍경식

IPC: A01N43/76

Abstract: 본 발명은 화학식 1로 표시되는 제초성 3-아릴-테트라히드로-1,2-벤즈이속사졸린-4-온 유도체에 관한 것이다.

상기식에서 Xn은 수소, C
1 -C
4 알킬기, C
2 -C
5 알케닐기, C
2 -C
5 알키닐기, C
1 -C
4 알콕시기, C
1 -C
4 할로알킬기, C
1 -C
4 알콕시카보닐기, 아미노카보닐기, 카복시기, 메탄설포닐기, 니트로기, 히드록시기, 니트릴기, 또는 이들의 둘이상의 복합치환기를 나타낸다.

公开(公告)号：KR1019920018048A

公开(公告)日：1992-10-21

申请号：KR1019910004063

申请日：1991-03-14

Applicant: 한국화학연구원

Inventor： 김대황 ,  전동주 ,  박상순 ,  우재춘 ,  김태준

IPC: C07D405/12

Abstract: 내용 없음