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公开(公告)号：BR9810760A
公开(公告)日：2001-11-27
申请号：BR9810760
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：NO20013669L
公开(公告)日：2001-09-27
申请号：NO20013669
申请日：2001-07-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：NO20013669D0
公开(公告)日：2001-07-26
申请号：NO20013669
申请日：2001-07-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , C07D
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：HK1028023A1
公开(公告)日：2001-02-02
申请号：HK00107516
申请日：2000-11-23
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：TR9903287T2
公开(公告)日：2000-09-21
申请号：TR9903287
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
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Patent Agency Ranking
公开(公告)号：PL337854A1
公开(公告)日：2000-09-11
申请号：PL33785498
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AU2739100A
公开(公告)日：2000-08-18
申请号：AU2739100
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：CZ9904730A3
公开(公告)日：2000-06-14
申请号：CZ473099
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN ROBIN H , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: A61K31/16 , A61P19/02 , A61P35/00 , C07C259/00 , C07C259/04
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公开(公告)号：AU710666B2
公开(公告)日：1999-09-23
申请号：AU7729696
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , SUMMERS JAMES B JR , DAVIDSEN STEVEN K , SHEPPARD GEORGE S , STEINMAN DOUGLAS H , CARRERA GEORGE M JR , FLORJANCIC ALAN , HOLMS JAMES H
IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16
Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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公开(公告)号：PT100698B
公开(公告)日：1999-07-30
申请号：PT10069892
申请日：1992-07-16
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , STEINMAN DOUGLAS H , MARTIN MICHAEL B , CARRERA GEORGE M JR , HOLMS JAMES H , PIREH DAISY , HEYMAN ROBIN H , SHEPPARD GEORGE S , DAVIDSEN STEVE K
IPC: A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61K31/44 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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