公开(公告)号：CA2245546A1

公开(公告)日：1997-08-14

申请号：CA2245546

申请日：1997-02-11

Applicant: BASF AG

Inventor： H FFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  RUEBSAMEN KLAUS ,  SCHMIDT MARTIN ,  BOLLSCHWEILER CLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment ArgAsp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：SI9520048A

公开(公告)日：1997-02-28

申请号：SI9520048

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  C07D251/26 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：NZ283333A

公开(公告)日：1997-02-24

申请号：NZ28333395

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  C07D251/26 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D239/00 ,  C07D251/00

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：AT146526T

公开(公告)日：1997-01-15

申请号：AT92919916

申请日：1992-09-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

公开(公告)号：NO964121A

公开(公告)日：1996-11-26

申请号：NO964121

申请日：1996-09-27

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：FI963885A0

公开(公告)日：1996-09-27

申请号：FI963885

申请日：1996-09-27

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：BRPI0611240A2

公开(公告)日：2016-11-16

申请号：BRPI0611240

申请日：2006-05-31

Applicant: BASF AG

Inventor： MENDERA CHRISTINE ,  BOLLSCHWEILER CLAUS ,  LEMAIRE HANS-GEORG ,  KAROS MARVIN ,  BAUR RICHARD ,  SUBKOWSKI THOMAS ,  MONTAG THORSTEN ,  BAUS ULF ,  SCHWENDEMANN VOLKER

IPC: D06M15/15

公开(公告)号：EA012800B1

公开(公告)日：2009-12-30

申请号：EA200702156

申请日：2006-03-29

Applicant: BASF AG

Inventor： POSSELT DIETMAR ,  SCHMITT WERNER ,  GUZMANN MARCUS ,  KORMANN CLAUDIUS ,  KIEFER MATTHIAS ,  BOLLSCHWEILER CLAUS ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  KAROS MARVIN ,  BAUS ULF

IPC: B01D17/04 ,  B01D17/05 ,  C07K14/375 ,  C10G33/04 ,  C10L1/22 ,  C10L1/24 ,  C10L1/26

Abstract: Данноеизобретениекасаетсяпримененияпокрайнеймереодногобелка, вчастностиодногогидрофобинаилипокрайнеймереодногоегопроизводного, дляулучшенияразделенияфазв составах, содержащихпоменьшеймередвежидкиефазы, способаразделенияпоменьшеймередвухжидкихфазв составе, содержащемпоменьшеймередвежидкиефазы, атакжекомпозиций, содержащихпоменьшеймереодносоединение, выбранноеизгруппы, состоящей, поменьшеймере, изгорючего, топлива, сыройнефтиилирастворовполимеров, растворимыхв водеилив масле, ипоменьшеймереодногобелка, вчастностигидрофобинаилиегопроизводного.

公开(公告)号：CA2642375A1

公开(公告)日：2009-05-02

申请号：CA2642375

申请日：2008-10-30

Applicant: BASF AG

Inventor： BODE ANDREAS ,  HUFF JUERGEN ,  GUZMANN MARCUS ,  WUENSCH JOSEF RICHARD ,  SUBKOWSKI THOMAS ,  STEIN STEFAN ,  KAROS MARVIN ,  SCHOLTISSEK MARTIN ,  BECHTLOFF BERND ,  BAUS ULF ,  BOLLSCHWEILER CLAUS

IPC: C10G1/04

Abstract: A process for extracting hydrocarbons from oil sand, in which the oil sand i s treated in a separation apparatus in at least one process step with a composition which comprises water and a hydrophobin and if appropriate further assistants, lea ds to an improved yield of hydrocarbons.

公开(公告)号：NZ551366A

公开(公告)日：2009-01-31

申请号：NZ55136605

申请日：2005-05-24

Applicant: BASF AG

Inventor： BARG HEIKO ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  PTOCK ARNE

IPC: A61K8/64 ,  A61Q1/02 ,  A61Q3/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/10 ,  C07K14/47 ,  A61K7/48 ,  A61K7/06 ,  A61K7/04

Abstract: Disclosed is are keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.