公开(公告)号：DE4041463A1

公开(公告)日：1992-06-25

申请号：DE4041463

申请日：1990-12-22

Applicant: BASF AG

Inventor： STEINER GERD DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D295/155

Abstract: The description relates to the use of 5-cyanomethylene-10-(piperazine-1-yl)-dibenzo[a,d]cycloheptenes of formula (I), in which R , R and R have the significance given in the specification, for relieving migraine.

公开(公告)号：DE4032766A1

公开(公告)日：1992-04-30

申请号：DE4032766

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：DE3425632A1

公开(公告)日：1986-01-16

申请号：DE3425632

申请日：1984-07-12

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  RASCHACK MANFRED DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR MED ,  RUEBSAMEN HANS DR ,  SCHMIED BERNHARD DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D237/14 ,  A61K31/495

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.

公开(公告)号：GR75859B

公开(公告)日：1984-08-02

申请号：GR820167244

申请日：1982-02-08

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  MUELLER CLAUS D DR ,  RASCHACK MANFRED DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：DE2860111D1

公开(公告)日：1980-11-27

申请号：DE2860111

申请日：1978-06-13

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  FRIEDRICH LUDWIG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  MUELLER CLAUS DR ,  RASCHACK MANFRED DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

公开(公告)号：DE2841074A1

公开(公告)日：1980-04-03

申请号：DE2841074

申请日：1978-09-21

Applicant: BASF AG

Inventor： ALBRECHT HANS PETER DIPL CHEM ,  PHILIPSBORN GERDA VON DR MED ,  SIEBENEICK HANS ULRICH DIPL CH ,  RASCHACK MANFRED DR

IPC: A61K31/704 ,  A61P9/04 ,  C07J19/00 ,  C07J53/00 ,  A61K31/705

Abstract: 4,5-methano-bufadienolide-rhamnosides of the formula I I where R1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R2 and R3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are where R4 and R5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms. The novel compounds may be used for counteracting cardiac insufficiency.