-
公开(公告)号：NZ597823A
公开(公告)日：2014-05-30
申请号：NZ59782310
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: 597823 Disclosed herein are pharmaceutical compositions comprising a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1) for use treating or lessening the severity of cystic fibrosis in a patient, and method of manufacturing said compositions. In a preferred embodiment the patient possesses a cystic fibrosis transmembrane receptor (CFTR) with a &Dgr;F508 mutation or G551D mutation on both alleles.
-
公开(公告)号：NZ592504A
公开(公告)日：2013-04-26
申请号：NZ59250409
申请日：2009-10-23
Applicant: VERTEX PHARMA
Inventor： ZHANG BEILI , KRAWIEC MARIUSZ , BOTFIELD MARTYN , GROOTENHUIS PETER D
IPC: C07D215/56 , A61K31/4704 , A61P1/00 , A61P11/00
Abstract: 592504 The present disclosure relates to solid state forms, for example, crystalline forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide - compound 1, pharmaceutical compositions thereof, and methods therewith. The Form A is characterized by one or more peaks in an X-ray powder diffraction pattern selected from about 7.9, about 9.3, about 11.9, about 14.4, about 15.1, about 15.8, about 17.0, about 17.7, about 19.3, about 20.1, about 21.4, about 21.8, about 23.4, about 23.8, about 25.6, about 26.8, about 29.4, about 29.7, about 30.1 or about 31.2 degrees 2 theta.
-
公开(公告)号：HK1161140A1
公开(公告)日：2012-08-24
申请号：HK12102076
申请日：2012-02-29
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K20060101
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
-
公开(公告)号：CA2769695A1
公开(公告)日：2011-02-17
申请号：CA2769695
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F , VERWIJS MARINUS JACOBUS
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
-
公开(公告)号：CA2742042A1
公开(公告)日：2010-04-29
申请号：CA2742042
申请日：2009-10-23
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , FANNING LEV T D , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
IPC: C07D487/08 , A61K31/4709 , A61P11/00 , A61P43/00
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR (Formula I) or pharmaceutically acceptable salts thereof, wherein: ring A is selected from: (a), (b), (c), (d), wherein: R1 is -CH3 -CF3 or -CN; R2 is hydrogen, -CH3, -CF3, -OH, or -CH2OH; R3 is hydrogen, -CH3, -OCH3, or -CN; provided that both R2 and R3 are not simultaneously hydrogen; and one of X and Y is nitrogen and the other is carbon.
-
Patent Agency Ranking
公开(公告)号：AU2005249446A8
公开(公告)日：2010-03-04
申请号：AU2005249446
申请日：2005-05-27
Applicant: VERTEX PHARMA
Inventor： RAMACHANDRAN RAVI , BOTFIELD MARTYN , HARDING MATTHEW W , JAIN-PANDEY JUGNU
Abstract: The present invention is directed to methods for ameliorating reproductive disorders. More specifically, the present invention describes methods and compositions for using IL-17 in the treatment of various infertility-related defects.
-
公开(公告)号：AT425967T
公开(公告)日：2009-04-15
申请号：AT03756899
申请日：2003-10-02
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , BOTFIELD MARTYN , ECKARD OTTOW
IPC: C07D211/60 , A61K31/496 , A61P25/28 , C07D207/16
Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
-
公开(公告)号：DK2464337T4
公开(公告)日：2024-07-22
申请号：DK10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
-
公开(公告)号：ES2857152T3
公开(公告)日：2021-09-28
申请号：ES17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
Abstract: Una composición farmacéutica que comprende una dispersión sólida, en donde la dispersión sólida comprende: a) 80% en peso de N-[2,4-Bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida (Compuesto 1) amorfa o sustancialmente amorfa por peso de la dispersión, en donde el Compuesto 1 sustancialmente amorfo comprende menos del 15% de Compuesto 1 cristalino, b) 19,5% en peso de succinato de acetato de hidroxipropilmetilcelulosa (HPMCAS) o copolímero de vinilpirrolidona/acetato de vinilo (PVP/VA) por peso de la dispersión, y c) 0,5% en peso de lauril sulfato de sodio (SLS) por peso de la dispersión.
-
公开(公告)号：HRP20210208T1
公开(公告)日：2021-03-19
申请号：HRP20210208
申请日：2021-02-05
Applicant: VERTEX PHARMA
-
-
-
-
-
-
-
-
-
Search Results
101
records
(took 0.022 seconds)
