公开(公告)号：NO20021931L

公开(公告)日：2002-04-24

申请号：NO20021931

申请日：2002-04-24

Applicant: BASF AG

Inventor： KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  MATTES RALF

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P17/04 ,  C12P41/00 ,  C12R1/19

Abstract: The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a process for preparing D-pantolactone.

公开(公告)号：NO20021931A

公开(公告)日：2002-04-24

申请号：NO20021931

申请日：2002-04-24

Applicant: BASF AG

Inventor： KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  MATTES RALF

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P17/04 ,  C12P41/00 ,  C12R1/19

CPC classification number: C12P17/04 ,  C12N9/18 ,  C12P41/005

公开(公告)号：AU8404701A

公开(公告)日：2002-03-13

申请号：AU8404701

申请日：2001-08-30

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUBLING CHRISTOPH ,  STURMER RAINER ,  LADNER WOLFGANG

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P7/62 ,  C12P41/00

Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

公开(公告)号：CA2419275A1

公开(公告)日：2002-03-07

申请号：CA2419275

申请日：2001-08-30

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  STURMER RAINER ,  LADNER WOLFGANG ,  FRIEDRICH THOMAS ,  HAUER BERNHARD

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P7/62 ,  C12P41/00 ,  C12P7/00 ,  C12N1/20 ,  C12N15/63

Abstract: The invention relates to novel proteins exhibiting esterase activity, in particular butinol I esterase activity, obtained from Pseudomonas glumae and to nucleic acid sequences that code therefor, expression cassettes, vectors and recombinant microorganisms. The invention also relates to a method for producing said proteins and to the use thereof for the enzymatic, in particular, enantioselective ester hydrolysis or interesterification of organic esters.

公开(公告)号：DE10019377A1

公开(公告)日：2001-10-25

申请号：DE10019377

申请日：2000-04-19

Applicant: BASF AG

Inventor： FALKE PETER ,  HENDREICH REGINA ,  STUERMER RAINER ,  FRIEDRICH THOMAS

IPC: C12N11/08 ,  C12P41/00 ,  C12N11/14 ,  C12P1/00

Abstract: Process (I) for immobilizing a biologically active substance comprising contacting a foamed polymeric material with the substance, is new. Independent claims are also included for the following: (1) products (II) obtainable by process (I); and (2) chiral syntheses performed using (II) at 5-80 deg C.

公开(公告)号：AU1141601A

公开(公告)日：2001-05-14

申请号：AU1141601

申请日：2000-10-20

Applicant: BASF AG

Inventor： KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  MATTES RALF

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P17/04 ,  C12P41/00 ,  C12R1/19

Abstract: The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a process for preparing D-pantolactone.

公开(公告)号：DE19840069A1

公开(公告)日：2000-03-09

申请号：DE19840069

申请日：1998-09-03

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BEWERT WOLFGANG ,  LUEDDECKE ERIK ,  KLINGLER JUERGEN ,  HEGER ROBERT

IPC: A23K20/174 ,  A23K20/189 ,  A23K40/30 ,  A23L33/15 ,  C12N9/06 ,  C07K7/08 ,  A61K38/43 ,  C07K7/06

Abstract: A method to manufacture a preparation of an active substance is new, where the active substance is surrounded by at least one layer consisting of a protein that is cross-linked by an enzyme chosen from the group of lipoxygenase, protein disulfide isomerase, phenol oxidase and peroxidase, lysyl oxidase, protein disulfide reductase, tyrosine oxidase or sulfhydryl oxidases. Independent claims are also included for: (1) an active substance preparation prepared by a method as above; and (2) an isolated protein comprising at least one of the 12 sequences given in the specification.

公开(公告)号：CZ9900348A3

公开(公告)日：1999-11-17

申请号：CZ34899

申请日：1997-07-30

Applicant: BASF AG

Inventor： FUCHS HARALD ,  FRIEDRICH THOMAS ,  SCHREEPP WOLFGANG

IPC: G01N33/543 ,  G01Q60/20

CPC classification number: G01Q60/20 ,  G01N33/54373

公开(公告)号：HU9900574A2

公开(公告)日：1999-06-28

申请号：HU9900574

申请日：1997-02-11

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS ,  FRIEDRICH THOMAS ,  HOEFFKEN HANS WOLFGANG ,  RADITSCH MARTIN ,  RUEBSAMEN KLAUS ,  SCHMIDT MARTIN ,  SCHWEDEN JUERGEN

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：NO983677A

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  H FFKEN HANS WOLFGANG ,  SCHWEDEN J RGEN ,  R BSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005